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Erschienen in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie 3/2015

01.05.2015 | Original article

Effect of untreated and treated temporomandibular joint arthritis on mandibular volume development in growing rabbits

verfasst von: Dr. Dr. T.M. Präger, S. Rafayelyan, H. Landau, N. Pischon, K. Minden, P.-G. Jost-Brinkmann, R. Müller-Hartwich, A. Mußler

Erschienen in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie | Ausgabe 3/2015

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Abstract

Objectives

The goal of this work was to investigate the volume development of the mandible in growing rabbits with bilaterally induced temporomandibular joint (TMJ) arthritis that was either left untreated or treated with the tumor necrosis factor-alpha (TNF-α) antagonist etanercept.

Methods

A total of 18 New Zealand White rabbits aged 8 weeks were randomized to three groups of 6 animals each. Two of these groups were used as arthritis groups by sensitizing the 12 animals to ovalbumin (OA) at 10 weeks, followed by intraarticular OA injections to induce bilateral TMJ arthritis and repeating these injections every 3 weeks to maintain the inflammation. One of the two arthritis groups was treated by weekly subcutaneous etanercept injections, whereas the other group was left untreated. The remaining 6 animals served as controls. Maxillofacial CT scans were obtained at 3-week intervals (from week 10 of the rabbits’ lives to the end of the experiment at 22 weeks) to volumetrically track the development of the mandibles after segmentation.

Results

The mandibles did not grow at a continuous rate, but the rate of development was found to decrease in all groups over the course of the study (weeks 10–22). The most extensive volume increases were noted during weeks 10–13. Severe growth deficiencies, especially of the condylar processes, were observed in the arthritis group not receiving treatment. The arthritis group treated with etanercept showed better rates of growth without, however, reaching the normal range of the control group.

Conclusion

Antigen-induced TMJ arthritis was found to involve severe problems of growth similar to those in juvenile idiopathic arthritis. Etanercept can improve the volume development but does not reestablish an entirely normal rate of growth.
Literatur
1.
2.
Zurück zum Zitat Bryndahl F, Legrell PE, Eriksson L et al (2004) Titanium screw implants in optimization of radiographic evaluation of facial growth in longitudinal animal studies. Angle Orthod 74:610–617PubMed Bryndahl F, Legrell PE, Eriksson L et al (2004) Titanium screw implants in optimization of radiographic evaluation of facial growth in longitudinal animal studies. Angle Orthod 74:610–617PubMed
3.
Zurück zum Zitat Bryndahl F, Eriksson L, Legrell PE et al (2006) Bilateral TMJ disk displacement induces mandibular retrognathia. J Dent Res 85:1118–1123CrossRefPubMed Bryndahl F, Eriksson L, Legrell PE et al (2006) Bilateral TMJ disk displacement induces mandibular retrognathia. J Dent Res 85:1118–1123CrossRefPubMed
4.
Zurück zum Zitat Dahlberg G (1940) Statistical methods for medical and biological students. Allen and Unwin, London Dahlberg G (1940) Statistical methods for medical and biological students. Allen and Unwin, London
5.
Zurück zum Zitat Dannecker GE, Quartier P (2009) Juvenile idiopathic arthritis: classification, clinical presentation and current treatments. Horm Res 72(Suppl 1):4–12CrossRefPubMed Dannecker GE, Quartier P (2009) Juvenile idiopathic arthritis: classification, clinical presentation and current treatments. Horm Res 72(Suppl 1):4–12CrossRefPubMed
6.
Zurück zum Zitat Gartlehner G, Hansen RA, Jonas BL et al (2008) Biologics for the treatment of juvenile idiopathic arthritis: a systematic review and critical analysis of the evidence. Clin Rheumatol 27:67–76CrossRefPubMed Gartlehner G, Hansen RA, Jonas BL et al (2008) Biologics for the treatment of juvenile idiopathic arthritis: a systematic review and critical analysis of the evidence. Clin Rheumatol 27:67–76CrossRefPubMed
7.
Zurück zum Zitat Kapila S, Lee C, Tavakkoli Jou MR et al (1995) Development and histologic characterizations of an animal model of antigen-induced arthritis of the juvenile rabbit temporomandibular joint. J Dent Res 74:1870–1879CrossRefPubMed Kapila S, Lee C, Tavakkoli Jou MR et al (1995) Development and histologic characterizations of an animal model of antigen-induced arthritis of the juvenile rabbit temporomandibular joint. J Dent Res 74:1870–1879CrossRefPubMed
8.
Zurück zum Zitat Kristensen KD, Stoustrup P, Küseler A et al (2008) Quantitative histological changes of repeated antigen-induced arthritis in the temporomandibular joints of rabbits treated with intra-articular corticosteroid. J Oral Pathol Med 37:437–444CrossRefPubMed Kristensen KD, Stoustrup P, Küseler A et al (2008) Quantitative histological changes of repeated antigen-induced arthritis in the temporomandibular joints of rabbits treated with intra-articular corticosteroid. J Oral Pathol Med 37:437–444CrossRefPubMed
9.
Zurück zum Zitat Kristensen KD, Stoustrup P, Küseler A et al (2009) Intra-articular vs. systemic administration of etanercept in antigen-induced arthritis in the temporomandibular point. Part I: histological effects. Pediatr Rheumatol Online J 7:5CrossRefPubMedCentralPubMed Kristensen KD, Stoustrup P, Küseler A et al (2009) Intra-articular vs. systemic administration of etanercept in antigen-induced arthritis in the temporomandibular point. Part I: histological effects. Pediatr Rheumatol Online J 7:5CrossRefPubMedCentralPubMed
10.
Zurück zum Zitat Kristensen KD, Hauge EM, Dalstra M et al (2011) Association between condylar morphology and changes in bony microstructure and sub-synovial inflammation in experimental temporomandibular joint arthritis. J Oral Pathol Med 40:111–120CrossRefPubMed Kristensen KD, Hauge EM, Dalstra M et al (2011) Association between condylar morphology and changes in bony microstructure and sub-synovial inflammation in experimental temporomandibular joint arthritis. J Oral Pathol Med 40:111–120CrossRefPubMed
11.
Zurück zum Zitat Landau H, Schroder R, Roth J (2005) Panoramic X-rays. Comprehensive radiodiagnostics or radiation protection at all costs? J Orofac Orthop 66:78–82CrossRefPubMed Landau H, Schroder R, Roth J (2005) Panoramic X-rays. Comprehensive radiodiagnostics or radiation protection at all costs? J Orofac Orthop 66:78–82CrossRefPubMed
12.
Zurück zum Zitat Losken A, Mooney MP, Siegel MI (1992) A comparative study of mandibular growth patterns in seven animal models. J Oral Maxillofac Surg 50:490–495CrossRefPubMed Losken A, Mooney MP, Siegel MI (1992) A comparative study of mandibular growth patterns in seven animal models. J Oral Maxillofac Surg 50:490–495CrossRefPubMed
13.
Zurück zum Zitat Lurati A, Salmaso A, Gerloni V et al (2009) Accuracy of Wallace criteria for clinical remission in juvenile idiopathic arthritis: a cohort study of 761 consecutive cases. J Rheumatol 36:1532–1535CrossRefPubMed Lurati A, Salmaso A, Gerloni V et al (2009) Accuracy of Wallace criteria for clinical remission in juvenile idiopathic arthritis: a cohort study of 761 consecutive cases. J Rheumatol 36:1532–1535CrossRefPubMed
14.
Zurück zum Zitat Masoud I, Shapiro F, Moses A (1986) Longitudinal roentgencephalometric study of the growth of the New Zealand white rabbit: cumulative and biweekly incremental growth rates for skull and mandible. J Craniofac Genet Dev Biol 6:259–287PubMed Masoud I, Shapiro F, Moses A (1986) Longitudinal roentgencephalometric study of the growth of the New Zealand white rabbit: cumulative and biweekly incremental growth rates for skull and mandible. J Craniofac Genet Dev Biol 6:259–287PubMed
15.
Zurück zum Zitat Mills DK, Daniel JC, Scapino R (1988) Histological features and in-vitro proteoglycan synthesis in the rabbit craniomandibular joint disc. Arch Oral Biol 33:195–202CrossRefPubMed Mills DK, Daniel JC, Scapino R (1988) Histological features and in-vitro proteoglycan synthesis in the rabbit craniomandibular joint disc. Arch Oral Biol 33:195–202CrossRefPubMed
16.
Zurück zum Zitat Mußler A, Allozy B, Landau H et al (2009) Vergleich magnetresonanztomographischer und klinischer Befunde im zeitlichen Verlauf bei Kindern und Jugendlichen mit einer Arthritis des Kiefergelenks bei juveniler ideopathischer Arthritis. Rofo 182:36–44CrossRefPubMed Mußler A, Allozy B, Landau H et al (2009) Vergleich magnetresonanztomographischer und klinischer Befunde im zeitlichen Verlauf bei Kindern und Jugendlichen mit einer Arthritis des Kiefergelenks bei juveniler ideopathischer Arthritis. Rofo 182:36–44CrossRefPubMed
17.
Zurück zum Zitat Othman AA, El-Beialy AR, Fawzy SA et al (2010) Methods for managing 3-dimensional volumes. Am J Orthod Dentofacial Orthop 137:266–273CrossRefPubMed Othman AA, El-Beialy AR, Fawzy SA et al (2010) Methods for managing 3-dimensional volumes. Am J Orthod Dentofacial Orthop 137:266–273CrossRefPubMed
18.
Zurück zum Zitat Pedersen TK, Kuseler A, Gelineck J et al (2008) A prospective study of magnetic resonance and radiographic imaging in relation to symptoms and clinical findings of the temporomandibular joint in children with juvenile idiopathic arthritis. J Rheumatol 35:1668–1675PubMed Pedersen TK, Kuseler A, Gelineck J et al (2008) A prospective study of magnetic resonance and radiographic imaging in relation to symptoms and clinical findings of the temporomandibular joint in children with juvenile idiopathic arthritis. J Rheumatol 35:1668–1675PubMed
19.
Zurück zum Zitat Pirttiniemi P, Peltomäki T, Müller L et al (2009) Abnormal mandibular growth and the condylar cartilage. Eur J Orthod 31:1–11CrossRefPubMed Pirttiniemi P, Peltomäki T, Müller L et al (2009) Abnormal mandibular growth and the condylar cartilage. Eur J Orthod 31:1–11CrossRefPubMed
20.
Zurück zum Zitat Rothe JH, Steffen IG, Lehmkuhl L et al (2010) Volume measurement of liver metastases using multidetector computed tomography: comparison of lesion diameter and volume segmentation—a phantom study. Rofo 182:1082–1090CrossRefPubMed Rothe JH, Steffen IG, Lehmkuhl L et al (2010) Volume measurement of liver metastases using multidetector computed tomography: comparison of lesion diameter and volume segmentation—a phantom study. Rofo 182:1082–1090CrossRefPubMed
21.
Zurück zum Zitat Sergl HG, Farmland M (1975) Experiments with unilateral bite planes in rabbits. Angle Orthod 45:108–114PubMed Sergl HG, Farmland M (1975) Experiments with unilateral bite planes in rabbits. Angle Orthod 45:108–114PubMed
22.
Zurück zum Zitat Steinbacher DM, Gougoutas A, Bartlett SP (2011) An analysis of mandibular volume in hemifacial microsomia. Plast Reconstr Surg 127:2407–2412CrossRefPubMed Steinbacher DM, Gougoutas A, Bartlett SP (2011) An analysis of mandibular volume in hemifacial microsomia. Plast Reconstr Surg 127:2407–2412CrossRefPubMed
23.
Zurück zum Zitat Stoustrup P, Kristensen KD, Kuseler A et al (2008) Reduced mandibular growth in experimental arthritis in the temporomandibular joint treated with intra-articular corticosteroid. Eur J Orthod 30:111–119CrossRefPubMed Stoustrup P, Kristensen KD, Kuseler A et al (2008) Reduced mandibular growth in experimental arthritis in the temporomandibular joint treated with intra-articular corticosteroid. Eur J Orthod 30:111–119CrossRefPubMed
24.
Zurück zum Zitat Stoustrup P, Kristensen KD, Kuseler A et al (2009) Intra-articular vs. systemic administration of etanercept in antigen-induced arthritis in the temporomandibular joint. Part II: mandibular growth. Pediatr Rheumatol Online J 7:6CrossRefPubMedCentralPubMed Stoustrup P, Kristensen KD, Kuseler A et al (2009) Intra-articular vs. systemic administration of etanercept in antigen-induced arthritis in the temporomandibular joint. Part II: mandibular growth. Pediatr Rheumatol Online J 7:6CrossRefPubMedCentralPubMed
25.
Zurück zum Zitat Stoustrup P, Kristensen KD, Kuseler A et al (2010) Condylar lesions in relation to mandibular growth in untreated and intra-articular corticosteroid-treated experimental temporomandibular joint arthritis. Clin Exp Rheumatol 28:576–583PubMed Stoustrup P, Kristensen KD, Kuseler A et al (2010) Condylar lesions in relation to mandibular growth in untreated and intra-articular corticosteroid-treated experimental temporomandibular joint arthritis. Clin Exp Rheumatol 28:576–583PubMed
26.
Zurück zum Zitat Tavakkoli-Jou M, Miller AJ, Kapila S (1999) Mandibulofacial adaptations in a juvenile animal model of temporomandibular joint arthritis. J Dent Res 78:1426–1435CrossRefPubMed Tavakkoli-Jou M, Miller AJ, Kapila S (1999) Mandibulofacial adaptations in a juvenile animal model of temporomandibular joint arthritis. J Dent Res 78:1426–1435CrossRefPubMed
27.
Zurück zum Zitat Tecco S, Saccucci M, Nucera R et al (2011) Condylar volume and surface in Caucasian young adult subjects. BMC Med Imaging 10:28CrossRef Tecco S, Saccucci M, Nucera R et al (2011) Condylar volume and surface in Caucasian young adult subjects. BMC Med Imaging 10:28CrossRef
28.
Zurück zum Zitat Tzaribachev N, Schafer J, Ernemann U et al (2009) Juvenile Idiopathische Arthritis—die heimliche Entzündung kindlicher Kiefergelenke. Rofo 181:303–305CrossRefPubMed Tzaribachev N, Schafer J, Ernemann U et al (2009) Juvenile Idiopathische Arthritis—die heimliche Entzündung kindlicher Kiefergelenke. Rofo 181:303–305CrossRefPubMed
29.
Zurück zum Zitat Veli I, Uysal T, Ozer T et al (2011) Mandibular asymmetry in unilateral and bilateral posterior crossbite patients using cone-beam computed tomography. Angle Orthod 81:966–974CrossRefPubMed Veli I, Uysal T, Ozer T et al (2011) Mandibular asymmetry in unilateral and bilateral posterior crossbite patients using cone-beam computed tomography. Angle Orthod 81:966–974CrossRefPubMed
30.
Zurück zum Zitat Bremen J von, Ruf S (2012) Juvenile idiopathic arthritis-and now?: a systematic literature review of changes in craniofacial morphology. J Orofac Orthop 73:265–276CrossRef Bremen J von, Ruf S (2012) Juvenile idiopathic arthritis-and now?: a systematic literature review of changes in craniofacial morphology. J Orofac Orthop 73:265–276CrossRef
31.
Zurück zum Zitat Bremen J von, Ruf S (2011) Orthodontic and dentofacial orthopedic management of juvenile idiopathic arthritis: a systematic review of the literature. Orthod Craniofac Res 14:107–115CrossRef Bremen J von, Ruf S (2011) Orthodontic and dentofacial orthopedic management of juvenile idiopathic arthritis: a systematic review of the literature. Orthod Craniofac Res 14:107–115CrossRef
32.
Zurück zum Zitat Yavuz MS, Buyukkurt MC, Tozoglu S et al (2009) Evaluation of volumetry and density of mandibular symphysis bone grafts by three-dimensional computed tomography. Dent Traumatol 25:475–479CrossRefPubMed Yavuz MS, Buyukkurt MC, Tozoglu S et al (2009) Evaluation of volumetry and density of mandibular symphysis bone grafts by three-dimensional computed tomography. Dent Traumatol 25:475–479CrossRefPubMed
33.
Zurück zum Zitat Yitschaky O, Redlich M, Abed Y et al (2011) Comparison of common hard tissue cephalometric measurements between computed tomography 3D reconstruction and conventional 2D cephalometric images. Angle Orthod 81:11–16CrossRefPubMed Yitschaky O, Redlich M, Abed Y et al (2011) Comparison of common hard tissue cephalometric measurements between computed tomography 3D reconstruction and conventional 2D cephalometric images. Angle Orthod 81:11–16CrossRefPubMed
Metadaten
Titel
Effect of untreated and treated temporomandibular joint arthritis on mandibular volume development in growing rabbits
verfasst von
Dr. Dr. T.M. Präger
S. Rafayelyan
H. Landau
N. Pischon
K. Minden
P.-G. Jost-Brinkmann
R. Müller-Hartwich
A. Mußler
Publikationsdatum
01.05.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie / Ausgabe 3/2015
Print ISSN: 1434-5293
Elektronische ISSN: 1615-6714
DOI
https://doi.org/10.1007/s00056-015-0288-2

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