Background
Methods
Enrolled boys
Puberty stage assessment
Group classification
Biochemical assessment
Statistics analysis
Results
General information
Group | NW | OW/OB | Z value |
p
| |
---|---|---|---|---|---|
Prepuberty | n | 465 | 155 | ||
Age (year) | 8.27 (6.92, 9.54) | 9.21 (7.93, 10.16) | 5.47 | < 0.0001 | |
Weight (kg) | 26.1 (23.0, 30.0) | 43.0 (38.50, 51.0) | 17.17 | < 0.0001 | |
BMI-SDS | −0.23 (− 0.77,0.33) | 3.29 (2.33, 4,77) | 18.92 | < 0.0001 | |
WC/height | 0.42 (0.40–0.44) | 0.54 (0.50–0.57) | 17.72 | < 0.0001 | |
Early puberty |
n
| 116 | 100 | ||
Age (year) | 11.44 (10.47, 12.36) | 11.12 (10.47, 11.78) | −2.62 | 0.01 | |
Weight (kg) | 36.00 (33.63, 40.00) | 52.45 (47.20, 59.88) | 11.77 | < 0.0001 | |
BMI-SDS | −0.18 (−0.72, 0.33) | 2.69 (2.010, 3.96) | 12.92 | < 0.0001 | |
WC/height | 0.41 (0.40–0.43) | 0.52 (0.50–0.56) | 12.18 | < 0.0001 | |
Mid puberty |
n
| 70 | 36 | ||
Age (year) | 13.42 (12.50, 14.12) | 12.70 (11.62, 13.49) | −3.06 | 0.003 | |
Weight (kg) | 45.00 (41.50, 50.00) | 60.70 (53.30, 76.13) | 6.66 | < 0.0001 | |
BMI-SDS | −0.17 (−0.60, 0.55) | 2.70 (1.97, 4.18) | 8.42 | < 0.0001 | |
WC/height | 0.40 (0.39–0.42) | 0.51 (0.49–0.56) | 9.92 | < 0.0001 | |
Late puberty |
n
| 101 | 44 | ||
Age (year) | 13.99 (13.38, 14.40) | 13.01 (11.82, 13.98) | −3.98 | < 0.0001 | |
Weight (kg) | 50.00 (46.75, 54.50) | 64.50 (54.63, 76.25) | 6.7 | < 0.0001 | |
BMI-SDS | −0.09 (−0.51, 0.42) | 2.69 (1.85, 3.50) | 9.55 | < 0.0001 | |
WC/height | 0.41 (0.39–0.42) | 0.51 (0.46–0.53) | 6.60 | < 0.0001 | |
Post puberty |
n
| 43 | 18 | ||
Age (year) | 14.26 (14.00, 14.66) | 13.84 (13.24, 14.23) | 2.78 | 0.005 | |
Weight (kg) | 56.00 (51.50, 61.00) | 81.00 (69.50, 93.25) | 5.54 | < 0.0001 | |
BMI-SDS | −0.30 (−0.31, 0.77) | 3.52 (2.60, 5.32) | 6.11 | < 0.0001 | |
WC/height | 0.41 (0.39–0.43) | 0.51 (0.46–0.56) | 5.31 | < 0.0001 |
Adrenal steroid hormone levels in different pubertal stages
Tanner stage | NW | OW/OB |
P
| |||
---|---|---|---|---|---|---|
N | Value |
N
| Value | |||
Pregnenolone (ug/l) | Prepuberty | 383 | 0.08(0.05–0.13) | 141 | 0.08(0.05–0.12) | 0.24 |
Early puberty
|
97
|
0.13(0.09–0.21)
|
93
|
0.09(0.05–0.14)
|
< 0.0001
| |
Mid puberty | 67 | 0.16(0.11–0.25) | 31 | 0.12(0.06–0.21) | 0.14 | |
Late puberty | 94 | 0.18(0.13–0.23) | 36 | 0.19(0.11–0.29) | 0.78 | |
Post puberty | 39 | 0.16(0.12–0.21) | 18 | 0.20(0.11–0.29) | 0.48 | |
Corticosterone(ug/l) | Prepuberty | 465 | 1.45 (0.87–2.92) | 155 | 1.41(0.77–3.00) | 0.59 |
Early puberty | 116 | 1.36 (0.80–2.98) | 100 | 1.62(0.88–3.38) | 0.32 | |
Mid puberty | 70 | 1.38(0.63–2.54) | 36 | 1.93(0.85–2.80) | 0.21 | |
Late puberty | 101 | 1.31 (0.75–2.25) | 44 | 1.07(0.72–2.80) | 0.49 | |
Post puberty | 43 | 1.58 (0.74–2.93) | 18 | 1.96(0.88–4.21) | 0.30 | |
17OH- progesterone (ng/ml) |
Prepuberty
|
465
|
0.22 (0.15–0.38)
|
155
|
0.34(0.22–0.49)
|
< 0.0001
|
Early puberty | 116 | 0.37 (0.26–0.51) | 100 | 0.40(0.33–0.58) | 0.05 | |
Mid puberty | 70 | 0.53 (0.36–0.75) | 36 | 0.54(0.43–0.66) | 0.59 | |
Late puberty | 101 | 0.65 (0.47–0.86) | 44 | 0.51(0.39–0.84) | 0.06 | |
Post puberty | 43 | 0.68 (0.49–0.94) | 18 | 0.62(0.54–0.88) | 0.47 | |
DHEA (ug/l) |
Prepuberty
|
465
|
0.70 (0.37–1.34)
|
155
|
1.49(0.88–2.31)
|
< 0.0001
|
Early puberty | 116 | 2.12 (1.56–3.16) | 100 | 2.31(1.66–3.30) | 0.23 | |
Mid puberty | 70 | 3.10 (2.21–4.24) | 36 | 3.34(2.26–5.07) | 0.34 | |
Late puberty | 101 | 3.65 (2.64–4.59) | 44 | 3.26(2.20–4.32) | 0.41 | |
Post puberty | 43 | 4.36 (2.83–5.49) | 18 | 3.57(2.54–5.55) | 0.98 | |
Androstenedione (ug/l) |
Prepuberty
|
465
|
0.18 (0.13–0.25)
|
155
|
0.24(0.17–0.33)
|
< 0.0001
|
Early puberty | 116 | 0.32 (0.23–0.44) | 100 | 0.36(0.27–0.44) | 0.37 | |
Mid puberty | 70 | 0.48 (0.34–0.65) | 36 | 0.52(0.30–0.72) | 0.86 | |
Late puberty
|
101
|
0.63 (0.48–0.77)
|
44
|
0.53(0.40–0.68)
|
0.02
| |
Post puberty | 43 | 0.71 (0.57–0.90) | 18 | 0.67(0.56–0.82) | 0.85 | |
FT (pg/ml) |
Prepuberty
|
465
|
0.97 (0.59–1.36)
|
155
|
1.26(0.90–1.76)
|
< 0.0001
|
Early puberty | 116 | 2.24 (1.69–3.49) | 100 | 2.34(1.61–3.11) | 0.68 | |
Mid puberty | 70 | 11.52 (5.66–23.35) | 36 | 6.79 (3.52–19.18) | 0.09 | |
Late puberty
|
101
|
26.39 (17.12–37.36)
|
44
|
15.76 (8.52–26.07)
|
0.0006
| |
Post puberty
|
43
|
34.16 (24.98–47.07)
|
18
|
24.47 (17.90–32.00)
|
0.02
| |
SHBG (nmol/L) |
Prepuberty
|
129
|
112.7 (87.8–150.2)
|
29
|
64.5 (41.6–117.1)
|
< 0.0001
|
Early puberty
|
42
|
79.54 (65.75–110.75)
|
31
|
45.1 (34–71.2)
|
< 0.0001
| |
Mid puberty | 24 | 43.25 (29.95–58.15) | 11 | 35 (17–50.8) | 0.12 |
Steroid hormone levels in different age groups (results shown in Table 3)
Age group | NW | OW/OB |
P
| |||
---|---|---|---|---|---|---|
N | Value |
N
| Value | |||
Pregnenolone (ug/l) | 6- < 10 years | 370 | 0.08(0.05–0.12) | 111 | 0.07(0.04–0.11) | 0.29 |
10- < 12 years
|
120
|
0.11(0.07–0.18)
|
135
|
0.08(0.05–0.13)
|
0.001
| |
12- < 15 years | 218 | 0.17(0.12–0.23) | 73 | 0.18(0.11–0.29) | 0.42 | |
Corticosterone(ug/l) | 6- < 10 years | 400 | 1.45 (0.88–2.86) | 117 | 1.47(0.96–3.36) | 0.45 |
10- < 12 years | 162 | 1.44 (0.83–2.98) | 148 | 1.48(0.78–3.11) | 0.85 | |
12- < 15 years | 234 | 1.33(0.74–2.76) | 87 | 1.50(0.77–2.98) | 0.49 | |
17OH-progesterone (ng/ml) |
6- < 10 years
|
400
|
0.20 (0.14–0.31)
|
117
|
0.32(0.19–0.49)
|
< 0.001
|
10- < 12 years | 162 | 0.38 (0.26–0.58) | 148 | 0.41(0.31–0.57) | 0.11 | |
12- < 15 years | 234 | 0.57 (0.42–0.81) | 87 | 0.56(0.42–0.79) | 0.77 | |
DHEA (ug/l) |
6- < 10 years
|
400
|
0.57 (0.28–0.96)
|
117
|
1.42(0.80–2.11)
|
< 0.0001
|
10- < 12 years
|
162
|
1.85 (1.26–2.73)
|
148
|
2.27(1.58–3.27)
|
0.004
| |
12- < 15 years | 234 | 3.40 (2.48–4.48) | 87 | 3.51(2.46–5.12) | 0.24 | |
Androstenedione (ug/l) |
6- < 10 years
|
400
|
0.14 (0.10–0.20)
|
117
|
0.23(0.15–0.32)
|
< 0.0001
|
10- < 12 years
|
162
|
0.30 (0.21–0.42)
|
148
|
0.36(0.27–0.45)
|
0.0035
| |
12- < 15 years | 234 | 0.58 (0.40–0.76) | 87 | 0.56(0.40–0.73) | 0.51 | |
FT (pg/ml) |
6- < 10 years
|
400
|
0.87 (0.52–1.22)
|
117
|
1.21(0.85–1.69)
|
< 0.0001
|
10- < 12 years
|
162
|
1.82 (1.42–2.85)
|
148
|
2.21(1.56–3.37)
|
0.02
| |
12- < 15 years
|
234
|
19.78 (8.22–34.40)
|
87
|
15.26(4.64–25.16)
|
0.01
| |
SHBG (nmol/L) |
6- < 10 years
|
96
|
110.9 (86.45–146.15)
|
25
|
71.1 (45.75–121.75)
|
0.002
|
10- < 12 years
|
64
|
102.4 (70.80–157.10)
|
33
|
45.10 (32.55–71.00)
|
< 0.0001
| |
12- < 15 years | 103 | 36.50 (28.00–49.30) | 23 | 36.90 (19.20–55.70) | 0.56 |