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Journal of Bone and Mineral Metabolism

Erschienen in:

29.08.2022 | Original Article

A novel serological biomarker are associated with disease severity in patients with osteoarthritis

verfasst von: Bin Li, Huixian Zhan, Jintao Luo, Xuewen Wang, Ting Cao, Biaofang Wei

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 6/2022

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Abstract

Background and aim

Apolipoprotein D (ApoD) is a 25–30 kDa glycoprotein, as a distinct component of the human plasma lipoprotein system. Its known biological functions are mainly related to lipid metabolism. The purpose of this study was to explore the potential role of ApoD concentration in knee osteoarthritis (KOA).

Methods

This study was performed in a population of 113 KOA subjects and 97 healthy controls. Serum ApoD was detected using the commercial ELISA kit (Cusabio, Wu Han, China, Cat No. CSB-EL001935HU). Radiographic progression was evaluated using Kellgren–Lawrence (KL) classification. The clinical severity of KOA was assessed by visual analog score (VAS), Hospital for special surgery (HSS) knee score disease duration and TNF-α. Receiver-operating characteristic (ROC) curve was performed to test the potential diagnostic value of ApoD in radiographic progression.

Results

The serum ApoD level of patients with KOA was significantly lower than that of healthy controls. The serum ApoD level was negatively correlated with KL grades, VAS score, disease duration, TNF-α concentrations. On the contrary, it was positively correlated with HSS score. However, there was no correlation between this serological indicator and which side was affected. ROC curve analysis indicated that attenuated serum ApoD could serve as an appropriate biomarker concerning the diagnosis of KOA.

Conclusions

Serum ApoD concentration was correlated with the presence and severity of KOA.

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Titel: A novel serological biomarker are associated with disease severity in patients with osteoarthritis
verfasst von: Bin Li
Huixian Zhan
Jintao Luo
Xuewen Wang
Ting Cao
Biaofang Wei
Publikationsdatum: 29.08.2022
Verlag: Springer Nature Singapore
Erschienen in: Journal of Bone and Mineral Metabolism / Ausgabe 6/2022
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-022-01364-0

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A novel serological biomarker are associated with disease severity in patients with osteoarthritis

Abstract

Background and aim

Methods

Results

Conclusions

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Abstract

Background and aim

Methods

Results

Conclusions

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