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23.09.2021 | Sleep Breathing Physiology and Disorders • Original Article

A novel, simple, and accurate pulse oximetry indicator for screening adult obstructive sleep apnea

verfasst von: Carlos Alberto Nigro, Gonzalo Castaño, Ignacio Bledel, Alfredo Colombi, María Cecilia Zicari

Erschienen in: Sleep and Breathing | Ausgabe 3/2022

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Abstract

Objective

The objective of the study was to develop a multiparametric oximetry indicator (IMp-SpO2) to diagnose obstructive sleep apnea in adults.

Material and method

This was an observational, retrospective study of diagnostic accuracy. We included adults who had had a diagnostic polysomnography with few artifacts and a total sleep time of at least 180 min in the sleep laboratory. Obstructive sleep apnea (OSA) was defined as an apnea-hypopnea index (AHI) ≥ 5. The database was randomly divided into an experimental (Exp-G) and validation (Val-G) group. The program calculated several parameters of oxygen saturation variability (Par-VarSpO2): (a) oxygen desaturation index (ODI ≥ 3, 4%) and (b) 90, 95, and 97.5 percentiles of both the number of oxygen desaturations ≥ 3 and 4% (P90–97.5 OD3/4 W5-60) and SpO2 standard deviations in moving windows from 5 to 60 min (P90–P97.5 SDSpO2 W5-10). Area under the ROC curve (AUC-ROC), sensitivity, specificity, positive/negative likelihood ratios, and accuracy were calculated.

Results

Of 1141 adults included in the study, experimental (571) and validation group (570) were similar (women 47% vs 45%, BMI 27.5 kg/m² vs 27.2 kg/m², and AHI 11.7 vs 12, p NS). The IMp-SpO2 developed in the experimental group consisted of a combination of 10 parameters of oxygen saturation variability. The presence of at least one IMp-SpO2 variable had a high diagnostic performance for OSA (sensitivity/specificity/accuracy: Exp-G: 92.8/94/93.2%; Val-G: 93/95.2/93.7%). The IMp-SpO2 AUC-ROC was higher (Exp-G 0.934, Val-G 0.941) than most of the Par-VarSpO2 (0.898–0.929, p < 0.05).

Conclusion

The IMp-SpO2 showed a > 90% accuracy for OSA diagnosis in adults.

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Titel: A novel, simple, and accurate pulse oximetry indicator for screening adult obstructive sleep apnea
verfasst von: Carlos Alberto Nigro
Gonzalo Castaño
Ignacio Bledel
Alfredo Colombi
María Cecilia Zicari
Publikationsdatum: 23.09.2021
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 3/2022
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02439-4

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A novel, simple, and accurate pulse oximetry indicator for screening adult obstructive sleep apnea