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Head and Neck Pathology
Erschienen in: Head and Neck Pathology 2/2023

27.10.2022 | Original Paper

A Survey of Human Papillomavirus and Epstein-Barr virus Immunohistochemical Status in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC) 

verfasst von: Etrat Javadirad, Ali Mousavi Yekta, Roya Chegene Lorestani, Javad Azimivaghar

Erschienen in: Head and Neck Pathology | Ausgabe 2/2023

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Abstract

Background

Head and neck cancers are among the most prevalent cancers in the body. The aim of this study was to evaluate the expression of P16 and Epstein-Barr virus/latent membrane protein (EBV/LMP1) markers by immunohistochemistry in patients with squamous cell carcinoma of the head and neck.

Methods

In this study, all tissue samples of head and neck biopsies from 75 patients with confirmed diagnosis of squamous cell carcinoma (HNSCC) during 2016 to 2018 who admitted to the pathology laboratory of Imam Khomeini Hospital, Iran were selected. Paraffin blocks which prepared from these tissue samples were obtained. The slides were prepared from all samples for routine Hematoxylin-Eosin and immunohistochemical staining to evaluate the expression of EBV/LMP1 and P16 markers in cancer cells.

Results

The mean age of patients was 63 years and most patients (85.3%) were male in 75 patients with HNSCC. There was a significant relationship between EBV/LMP1 biomarker expression and vascular invasion in patients (p < 0.05). There was no relationship between EBV/LMP1 biomarker expression and age, sex ,anatomical site of tumor and tumor differentiation of patients (p > 0.05). There was no relationship between P16 biomarker expression and age, sex, tumor differentiation, anatomical site of tumor and vascular invasion of patients (p > 0.05). There is a significant relationship between P16 biomarker and EBV/LMP1 biomarker staining (p < 0.05).

Conclusion

The level of P16 positive biomarker was high in patients with HNSCC. However, the EBV/LMP1 positive biomarker was moderate in patients. There was a relationship between EBV/LMP1 biomarker expression and vascular invasion in HNSCC patients, as well as between P16 biomarker and EBV/LMP1 biomarker staining.
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Metadaten
Titel
A Survey of Human Papillomavirus and Epstein-Barr virus Immunohistochemical Status in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC) 
verfasst von
Etrat Javadirad
Ali Mousavi Yekta
Roya Chegene Lorestani
Javad Azimivaghar
Publikationsdatum
27.10.2022
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 2/2023
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-022-01483-0

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