Abstracts: Young Investigators
Y01 A multivariate analysis of 82 consecutive patients shunted for idiopathic normal pressure hydrocephalus
Amit R Persad1, Bashir Daud Shah2, Kotoo Meguro1
1Division of Neurosurgery, Department of Surgery, University of Saskatchewan, Canada; 2Division of Neurology, Department of Medicine, University of Saskatchewan, Canada
Correspondence: Amit Persad (amit.persad@usask.ca)
Y02 A novel model of acquired hydrocephalus for evaluation of neurosurgical treatments
Sarah Zwick1, Pat McAllister1, Michael Talcott1,2, Albert Isaacs3, Maria Garcia-Bonilla1, Leandro Castaneyra-Ruiz1, Alexis Hartman1, Ryan Dilger4,5, Stephen Fleming4,5, Rebecca Golden4, Diego Morales1, Carolyn Harris6,7, David Limbrick Jr.1,8
1Department of Neurosurgery, Washington University in St. Louis School of Medicine, St. Louis, Missouri, 63110, USA; 2Division of Comparative Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri, 63110, USA; 3Department of Surgery, Division of Neurosurgery, University of Calgary School of Medicine, Calgary, Alberta, T2N2T0, Canada; 4Department of Animal Sciences, Division of Nutritional Sciences, Neuroscience Program, University of Illinois, Champaign-Urbana, Illinois, 61801, USA; 5Traverse Science, Champaign, Illinois, 61801, USA; 6Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, Michigan, 48202, USA; 7Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan, 48202, USA; 8Department of Pediatrics, St. Louis Children’s Hospital, St. Louis, Missouri, 63110, USA
Correspondence: Sarah Zwick (sarahzwick@hotmail.com)
Y03 Biochemical profile of human infant cerebrospinal fluid in intraventricular hemorrhage and post-hemorrhagic hydrocephalus of prematurity
Ayodamola Otun1, Diego Morales1,2, James P. McAllister II1, Maria Garcia-Bonilla1, David Limbrick1,2
1Department of Pediatric Neurosurgery, Washington University, St. Louis, MO, 63110, USA; 2St. Louis Children’s Hospital, MO, 63110, USA
Correspondence: Ayodamola Otun (aotun@wustl.edu)
Y04 Change in CSF pocket size after shunt placement in normal pressure hydrocephalus
Emanuele Camerucci1, Jonathan Graff-Radford2, David T. Jones2, Benjamin D. Elder3,4, Jeffrey L. Gunter1, Jeremy Cutsforth-Gregory2, Hugo Botha2, Matthew C. Murphy1, Clifford, R. Jack Jr1, John Huston III1, Petrice M. Cogswell1
1Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA; 2Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA; 3Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA; 4Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
Correspondence: Emanuele Camerucci (camerucci.emanuele@mayo.edu)
Y05 Establishment of age and gender specific normal cerebral ventricle volumes
Harrison Synder1, Xue Feng2, Min Park3, Jan Vargas4, Ryan T Kellogg3
1School of Medicine, University of Virginia, Charlottesville, VA, 22901, USA; 2Department of Biomedical Engineeering, University of Virginia, Charlottesville, VA, 22901, USA; 3Department of Neurological Surgery, University of Virginia, Charlottesville, VA, 22901, USA; 4Division of Neurosurgery, Prisma Health, Greenville, SC, 29605, USA
Correspondence: Ryan T Kellogg (rtk4u@virginia.edu)
Y06 Hydrocephalus in paediatric posterior fossa tumors: the role of pre-operative etv and analysis of risk factors for CSF diversion following tumour resection
Lucia Darie, Richard D.C. Moon, Michael R. Carter, Greg A. Fellows, Richard J. Edwards
1Department of Paediatric Neurosurgery, Bristol Royal Hospital for Children, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK
Correspondence: Lucia Darie (darielucia@yahoo.com)
Y07 Initial experiences with miethke m.blue® valve in inph patients
Petr Skalický1,3, Arnošt Mládek1,2, Aleš Vlasák3, Helen Whitley3, Ondřej Bradáč1,3
1Department of Neurosurgery and Neurooncology, 1st Faculty of Medicine, Charles University and Military University Hospital, Prague, Czech Republic; 2Department of Cognitive Systems and Neurosciences, Czech Institute of Informatics, Robotics and Cybernetics, Czech Technical University, Prague, Czech Republic; 3Department of Neurosurgery, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic
Correspondence: Petr Skalicky (skalicky.petr@uvn.cz)
Y08 Periventricular white matter changes are associated with less improvement after shunt surgery in iNPH patients
Carl Snöbohm1, Filip Malmberg2, David Fällmar3, Johan Virhammar1
1Department of Neuroscience, Neurology, Uppsala University, Sweden; 2Department of Information Technology, Division of Visual Information and Interaction, Uppsala University, Sweden; 3Department of Surgical Sciences, Radiology, Uppsala University, Sweden
Correspondence: Carl Snobohm (car.snobohm@gmail.com)
Y09 Usefulness of desh in predicting outcome of extended lumbar drainage and shunt insertion
Adam Nunn1, Melissa Werndle2, Joao Alves Rosa2, Kelly McManus1, Rebecca Hodnett1, Jack Wildman1, William Singleton1, Alex Mortimer2, Richard Edwards1
1Department of Neurosurgery, Southmead Hospital, Bristol, UK; 2Department of Neuroradiology, Southmead Hospital, Bristol, UK.
Correspondence: Adam Nunn (adam.nunn@nbt.nhs.uk)
Y10 variants in SWI/SNF complex component smarcc1 lead to developmental hydrocephalus and other syndromic features
Amrita K. Singh1, Stephen Viviano2, Phan Q. Duy1, Jay Ma3, August Allocco1, Tyrone Despenza1, Sheng Chih Jin3, Engin Deniz2, Kristopher T. Kahle1
1Department of Neurosurgery, Yale University, New Haven, Connecticut, United States; 2Department of Pediatrics, Yale University, New Haven, Connecticut, United States; 3Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States
Correspondence: Amrita Singh (amrita.singh@yale.edu)
Y11 Ventricular volumetry for non-invasive evaluation of shunt function
Simon Lidén1, Dan Farahmand2, Katarina Laurell1
1Department of Neuroscience, Neurology, Uppsala University, Sweden; 2Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, and Department of Neurosurgery, Sahlgrenska university Hospital, Sweden
Correspondence: Simon Liden (simon.liden@hotmail.com)
Y12 Ventricular zone response to blood exposure at various time points
Mira Zaranek1, Rooshan Arshad1, Kevin Zheng1, Carolyn Harris PhD1
1Chemical Engineering, Wayne State University, Detroit, Michigan, 48202, USA
Correspondence: Mira Zaranek (gf9749@wayne.edu)
Abstracts: Orals
O01 Analysis of intracranial pressure pulse waveforms during infusion tests
Arkadiusz Ziółkowski1, Agata Pudełko1, Agnieszka Kazimierska1, Zofia Czosnyka2, Marek Czosnyka2, Magdalena Kasprowicz1
1Department of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, Poland; 2Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, United Kingdom
Correspondence: Arkadiusz Ziolkowski (arkadiusz.ziolkowski@pwr.edu.pl)
O02 Assessing the utility of newly proposed evans’ index cutoffs for use in normal pressure hydrocephalus
Alexander Davis1
1Johns Hopkins University
Correspondence: Alexander Davis (adavi152@jhmi.edu)
O03 Association of pulsatile intracranial pressure with tonsillar descent and syringomyelia in chiari malformation I
Linda D’Antona1, Ruth Verity Passchier1, Claudia Craven1, Lucia Darie1, Lewis Thorne1, Laurence Watkins1, Ahmed Toma1
1Victor Horsley department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK
Correspondence: Linda D’Antona (lindadantona@me.com)
O04 Cerebrospinal fluid production rate in various pathological conditions: a preliminary study
Dr Kanza Tariq1, Mr Mohamed A. Elborady1, Linda D’Antona1, Lucia Daria1, Eleanor M. Moncur1, Mr Ahmed Toma1, Mr Lewis Thorne1, Mr Laurence Watkins1
1National Hospital for Neurology and Neurosurgery, Queen Square, London, U.K
Correspondence: Kanza Tariq (kanzaharisqureshi@outlook.com)
Disease
| Normal Pressure Hydrocephalus | Post-surgical CSF leak | Sub-Arachnoid Haemorrhage | Intracerebral Haemorrhage | Spinal Lesions | Pituitary Adenomas |
---|---|---|---|---|---|---|
Number of Patients Studied | 11 | 4 | 13 | 2 | 3 | 4 |
Average CSF production rate | 55–69 ml/ hour | 75–90 ml/ hour | 150 ml/ hour | 150 ml/ hour | 100–150 ml/hour | 26–36 ml/ hour |
P value | (p < 0.0001) | (p < 0.0001) | (p < 0.0001) | (p < 0.0001) | (p = 0.0032) | (p = 0.049) |
O05 Change in pituitary size as an indicator of disordered csf dynamics in normal pressure hydrocephalus
Emanuele Camerucci1, Jonathan Graff-Radford2, David T. Jones2, Benjamin D. Elder3,4, Jeffrey L. Gunter1, Jeremy Cutsforth-Gregory2, Hugo Botha2, Matthew C. Murphy1, Clifford R. Jack Jr1, John Huston III1, Petrice M. Cogswell1
1Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA;2Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA; 3Department of Neurologic Surgery; 4Department of Physiology and Biomedical Engineering
Correspondence: Emanuele Camerucci (camerucci.emanuele@mayo.edu)
O06 Choroid plexus tight junction disruption in an experimental model of intraventricular hemorrhage and post-hemorrhagic hydrocephalus
Ayodamola Otun1, Leandro Castaneyra-Ruiz1, James P. McAllister II1, Albert Isaacs1, Alexis Hartman1, Maria Garcia-Bonilla1, Sarah Zwick1, David Limbrick1,2
1Department of Pediatric Neurosurgery, Washington University, St. Louis, MO, 63,110, USA; 2St. Louis Children’s Hospital, St. Louis, MO, 63,110, USA
Correspondence: Ayodamola Otun (aotun@wustl.edu)
O07 Choroid plexus-on-a-chip: a microfluidic in vitro model to study the effect of inflammation on the blood-cerebrospinal fluid barrier
Hariharan Prashant1, Schwerk Christian4, Schroten Horst4, Blazer-Yost Bonnie3, Harris Carolyn1,2
1Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States; 2Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, United States; 3Department of Biology, Indiana University - Purdue University Indianapolis, IN, United States; 4Mannheim Medical Faculty, University of Heidelberg, Children’s Hospital, Mannheim, Germany,
Correspondence: Hariharan Prashant (fj1852@wayne.edu)
O08 Collaboration with local physicians is essential to recruiting undiagnosed idiopathic normal pressure hydrocephalus
Hisayuki Murai1, Toshimasa Shin2, Fumitaka Shinozaki1, Shiroh Ikegami1, Atsushi Fujikawa1
1Department of Neurosurgery, Saiseikai Narashino Hospital, Narashino, Chiba, 275-8580, Japan; 2Department of Neurosurgery, Higashi Funabashi Hospital, Funabashi, Chiba, 274-0065, Japan
Correspondence: Hisayuki Murai (murai@chiba-saiseikai.com)
O09 Correlation of 24 hour ICP monitoring analysis and ICP slow waves
Eleanor Moncur, Linda D’Antona, Lewis Thorne, Laurence Watkins, Ahmed Toma
1University College London Hospital
Correspondence: Eleanor Moncur (Eleanor.moncur@gmail.com)
O10 CSF diversion in selected chiari malformation i patients improves the crowding of the foramen magnum and reduces syrinx volume
Lucia Darie1, Mohamed Elborady1, Edward W Dyson1, Linda D'Antona1, Vejay Vakharia1, Janice Yiu2, Lewis W Thorne1, Ahmed K Toma1, Laurence D Watkins1
1Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, University Clinic London Hospitals, London, UK; 2Medical student at University College London Medical School, London, UK
Correspondence: Lucia Darie (darielucia@yahoo.com)
O11 Developing a multidisciplinary normal pressure hydrocephalus service: a quality improvement initiative
Samuel MT Jeffery1, Rupert Noad2, Susie Wolstenholme3, Aishah Hannan2, Cathryn Harries2, Alice Marler2, Tina O’Farrell1, Samiul Muquit1
1South West Neurosurgery Centre, Derriford Hospital, Plymouth, PL6 8DH, UK, 2Department of Neuropsychology, Derriford Hospital, Plymouth, PL6 8DH, UK, 3Department of Physiotherapy, Derriford Hospital, Plymouth, PL6 8DH, UK
Correspondence: Samuel Jeffery (samuel.jeffery1@nhs.net)
O12 Diagnostic test accuracy of extended lumbar drainage and receiver operating characteristic (roc) curve analysis of the optimal threshold for positivity
Adam Nunn1, Kelly McManus1, Rebecca Hodnett1, Richard Edwards1
1Department of Neurosurgery, Southmead Hospital, Bristol, UK
Correspondence: Adam Nunn (adam.nunn@nbt.nhs.uk)
O13 Enhanced hydrocephalus literature searches
Paul Relkin, Norman Relkin
1Mapscallion LLC, New Jersey, USA
Correspondence: Norman Relkin (nrmdphd@gmail.com)
O15 EVD management, what’s right and what’s wrong
Joanna Palasz1, Anand Pandit1,2, Linda D’Antona1,2, Ahmed Toma1
1Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK; 2UCL Queen Square Institute of Neurology, London, UK
Correspondence: Joanna Palasz (jopalasz@gmail.com)
O16 EVD-dependent hydrocephalus? An unconventional bargain with ICP
S. Krishnamurthy1, D. Gangoli2, A. Jagadeesh3*, S. Ganapathy4
1Senior Resident, Department of Neurosurgery, St Johns Medical College, Bengaluru, India; 2Junior Resident, Department of Neurosurgery, St Johns Medical College, Bengaluru, India; 3Assistant Professor, Department of Neurosurgery, St Johns Medical College, Bengaluru, India; 4Assistant Professor, Department of Neurosurgery, St Johns Medical College, Bengaluru, India.
Correspondence: Surabhi Krisnamurthi (drsurabhikrishnamurthy@gmail.com)
O17 Experimental catheter lab; a rapid prototyping and in-vitro testing of novel ventricular catheters and catheter modifications
Ahmad Faryami1, Rooshan Arshad2, Dr. Carolyn A. Harris3
1Biomedical Engineering, Wayne State University, Detroit, Michigan,48202 USA; 2School of Medicine, Wayne State University, Detroit, Michigan,48202 USA; 3Chemical Engineering and Material Science, Wayne State University, Detroit, Michigan,48202 USA
Correspondence: Ahmad Faryami (gw7895@wayne.edu)
O18 First 2-year experience from a pilot interdisciplinary normal pressure hydrocephalus clinic
Tobias Langheinrich1,2, Cliff Chen3, Owen Thomas4, Matthew Bailey5
1Department of Neurology, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, M6 8HD, UK; 2Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, M13 9PL, UK; 3Department of Neuropsychology, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, M6 8HD, UK; 4Department of Neuroradiology, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, M6 8HD, UK; 5Department of Neurosurgery, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, M6 8HD, UK
Correspondence: Tobias Langheinrich (tobias.langheinrich@srft.nhs.uk)
O19 First insights of posture related pressure dynamics in awake and freely moving rats
Simone Schwander1, Fabian Flürenbrock1,2, Britta Bausch3, Anthony Podgoršak1, Petra Seebeck4, Melanie Zeilinger2, Marianne Schmid Daners1
1Product Development Group Zurich, ETH Zurich, Zurich, 8092, Switzerland; 2Institute for Dynamic Systems and Control, ETH Zurich, Zurich, 8092, Switzerland; 3Interface Group, Institute of Physiology, University of Zurich, Zurich, 8057, Switzerland; 4Zurich Integrative Rodent Physiology, University of Zurich, Zurich, 8057, Switzerland
Correspondence: Simone Schwander (sischwan@ethz.ch)
O20 Frequency of abdominal pain relative to various types of shunt tubing
Dr Kanza Tariq1, Mr Mohamed A. Elborady1, Dr Maria Kneizeh Al Geriass1, Linda D’Antona1, Lucia Darie1, Eleanor M. Moncur1, Mr Ahmed Toma1, Mr Lewis Thorne1, Mr Laurence Watkins1
1National Hospital for Neurology and Neurosurgery, Queen Square, London, U.K
Correspondence: Kanza Tariq (kanzaharisqureshi@outlook.com)
Shunt Catheter According to Manufacturer | Number of patients studied | Average age | Number of Patients with abdominal pain | p value | Number of patients requiring revision surgery |
---|---|---|---|---|---|
Ares | 174 | 65 | 78 | p < 0.0001 | 10 |
Bactiseal | 125 | 67 | 10 | p = 0.314 | 1 |
Spiegelberg Silverline | 40 | 69 | 6 | p = 0.026 | 1 |
Plain tubing | 87 | 45 | 13 | p = 0.113 | 6 |