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15.04.2023 | NEURO-EPIDEMIOLOGY

Adherence to a healthy lifestyle and brain structural imaging markers

verfasst von: Yuesong Pan, Jie Shen, Xueli Cai, Hui Chen, Geng Zong, Wanlin Zhu, Jing Jing, Tao Liu, Aoming Jin, Yilong Wang, Xia Meng, Changzheng Yuan, Yongjun Wang

Erschienen in: European Journal of Epidemiology | Ausgabe 6/2023

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Abstract

Previous research has linked specific modifiable lifestyle factors to age-related cognitive decline in adults. Little is known about the potential role of an overall healthy lifestyle in brain structure. We examined the association of adherence to a healthy lifestyle with a panel of brain structural markers among 2,413 participants in PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study in China and 19,822 participants in UK Biobank (UKB). A healthy lifestyle score (0–5) was constructed based on five modifiable lifestyle factors: diet, physical activity, smoking, alcohol consumption, and body mass index. Validated multimodal neuroimaging markers were derived from brain magnetic resonance imaging. In the cross-sectional analysis of PRECISE, participants who adopted four or five low-risk lifestyle factors had larger total brain volume (TBV; β = 0.12, 95% CI: − 0.02, 0.26; p-trend = 0.05) and gray matter volume (GMV; β = 0.16, 95% CI: 0.01, 0.30; p-trend = 0.05), smaller white matter hyperintensity volume (WMHV; β = − 0.35, 95% CI: − 0.50, − 0.20; p-trend < 0.001) and lower odds of lacune (Odds Ratio [OR] = 0.48, 95% CI: 0.22, 1.08; p-trend = 0.03), compared to those with zero or one low-risk factors. Meanwhile, in the prospective analysis in UKB (with a median of 7.7 years’ follow-up), similar associations were observed between the number of low-risk lifestyle factors (4–5 vs. 0–1) and TBV (β = 0.22, 95% CI: 0.16, 0.28; p-trend < 0.001), GMV (β = 0.26, 95% CI: 0.21, 0.32; p-trend < 0.001), white matter volume (WMV; β = 0.08, 95% CI: 0.01, 0.15; p-trend = 0.001), hippocampus volume (β = 0.15, 95% CI: 0.08, 0.22; p-trend < 0.001), and WMHV burden (β = − 0.23, 95% CI: − 0.29, − 0.17; p-trend < 0.001). Those with four or five low-risk lifestyle factors showed approximately 2.0–5.8 years of delay in aging of brain structure. Adherence to a healthier lifestyle was associated with a lower degree of neurodegeneration-related brain structural markers in middle-aged and older adults.

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Titel: Adherence to a healthy lifestyle and brain structural imaging markers
verfasst von: Yuesong Pan
Jie Shen
Xueli Cai
Hui Chen
Geng Zong
Wanlin Zhu
Jing Jing
Tao Liu
Aoming Jin
Yilong Wang
Xia Meng
Changzheng Yuan
Yongjun Wang
Publikationsdatum: 15.04.2023
Verlag: Springer Netherlands
Erschienen in: European Journal of Epidemiology / Ausgabe 6/2023
Print ISSN: 0393-2990
Elektronische ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-023-00992-8

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

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Adherence to a healthy lifestyle and brain structural imaging markers

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Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

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