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Journal of NeuroVirology

Erschienen in:

27.08.2023 | Review

Advances in HIV therapeutics and cure strategies: findings obtained through non-human primate studies

verfasst von: Alison R. Van Zandt, Andrew G. MacLean

Erschienen in: Journal of NeuroVirology | Ausgabe 4/2023

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Abstract

Human immunodeficiency virus (HIV), the main contributor of the ongoing AIDS epidemic, remains one of the most challenging and complex viruses to target and eradicate due to frequent genome mutation and immune evasion. Despite the development of potent antiretroviral therapies, HIV remains an incurable infection as the virus persists in latent reservoirs throughout the body. To innovate a safe and effective cure strategy for HIV in humans, animal models are needed to better understand viral proliferation, disease progression, and therapeutic response. Nonhuman primates infected with simian immunodeficiency virus (SIV) provide an ideal model to study HIV infection and pathogenesis as they are closely related to humans genetically and express phenotypically similar immune systems. Examining the clinical outcomes of novel treatment strategies within nonhuman primates facilitates our understanding of HIV latency and advances the development of a true cure to HIV.

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Titel: Advances in HIV therapeutics and cure strategies: findings obtained through non-human primate studies
verfasst von: Alison R. Van Zandt
Andrew G. MacLean
Publikationsdatum: 27.08.2023
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 4/2023
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-023-01162-y

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