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Advances in Gerontology

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01.09.2023 | REVIEWS

Age-Related Changes and Loss of Damage Resistance of Kidney Tissue: The Role of a Decrease in the Number of Kidney Resident Progenitor Cells

verfasst von: M. I. Buyan, N. V. Andrianova, E. Yu. Plotnikov

Erschienen in: Advances in Gerontology | Ausgabe 3/2023

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Abstract

Many organs undergo negative changes during aging that affect their functions and ability to regenerate. In particular, the kidneys become more susceptible to acute injury and are more likely to develop chronic kidney disease with age. One of the reasons for this may be a decrease in the number of resident renal progenitor cells. This review addresses age-related changes that occur in the kidneys at the histological and molecular levels, including those related to the cell cycle, mitochondrial function, oxidative stress, and chronic inflammation. We described the available studies on resident renal stem cells, their niches, morphology, possible markers, and the dynamics of their numbers during the aging process. The reasons for the age-related decline in renal regenerative potential are considered based on molecular and cellular mechanisms.

Ferenbach, D.A. and Bonventre, J.V., Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD, Nat. Rev. Nephrol., 2015, vol. 11, no. 5, pp. 264–276.PubMedPubMedCentralCrossRef

Gros, J. et al., A common somitic origin for embryonic muscle progenitors and satellite cells, Nature, 2005, vol. 435, no. 7044, pp. 954–958.PubMedCrossRef

Apple, D.M., Solano-Fonseca, R., and Kokovay, E., Neurogenesis in the aging brain, Biochem. Pharmacol., 2017, vol. 141, pp. 77–85.PubMedCrossRef

Jasper, H., Intestinal stem cell aging: Origins and interventions, Annu. Rev. Physiol., 2020, vol. 82, pp. 203–226.PubMedCrossRef

Nyengaard, J.R. and Bendtsen, T.F., Glomerular number and size in relation to age, kidney weight, and body surface in normal man, Anat. Rec., 1992, vol. 232, no. 2, pp. 194–201.PubMedCrossRef

Rule, A.D. et al., The association between age and nephrosclerosis on renal biopsy among healthy adults, Ann. Intern. Med., 2010, vol. 152, no. 9, pp. 561–567.PubMedPubMedCentralCrossRef

Rule, A.D., Cornell, L.D., and Poggio, E.D., Senile nephrosclerosis—does it explain the decline in glomerular filtration rate with aging?, Nephron Physiol., 2011, vol. 119, Suppl. 1, pp. 6–11.

Wang, X., Bonventre, J.V., and Parrish, A.R., The aging kidney: Increased susceptibility to nephrotoxicity, Int. J. Mol. Sci., 2014, vol. 15, no. 9, pp. 15358–15376.PubMedPubMedCentralCrossRef

Yang, H. and Fogo, A.B., Cell senescence in the aging kidney, J. Am. Soc. Nephrol., 2010, vol. 21, no. 9, pp. 1436–1439.PubMedCrossRef

10.

Braun, H. et al., Cellular senescence limits regenerative capacity and allograft survival, J. Am. Soc. Nephrol., 2012, vol. 23, no. 9, pp. 1467–1473.PubMedPubMedCentralCrossRef

11.

Yang, L. et al., Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury, Nat. Med., 2010, vol. 16, no. 5, pp. 535–543.

12.

van Deursen, J.M., The role of senescent cells in ageing, Nature, 2014, vol. 509, no. 7501, pp. 439–446.PubMedPubMedCentralCrossRef

13.

Kang, D.H. et al., Impaired angiogenesis in the aging kidney: Vascular endothelial growth factor and thrombospondin-1 in renal disease, Am. J. Kidney Dis., 2001, vol. 37, no. 3, pp. 601–611.PubMedCrossRef

14.

Ruiz-Torres, M.P. et al., Age-related increase in expression of TGF-β1 in the rat kidney: Relationship to morphologic changes, J. Am. Soc. Nephrol., 1998, vol. 9, no. 5, pp. 782–791.PubMedCrossRef

15.

Thakar, C.V., et al., Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia, J. Clin. Invest., 2005, vol. 115, no. 12, pp. 3451–3459.PubMedPubMedCentralCrossRef

16.

Liguori, I. et al., Oxidative stress, aging, and diseases, Clin. Interv. Aging, 2018, vol. 13, pp. 757–772.PubMedPubMedCentralCrossRef

17.

Locatelli, F. et al., Oxidative stress in end-stage renal disease: An emerging threat to patient outcome, Nephrol. Dial. Transplant., 2003, vol. 18, no. 7, pp. 1272–1280.PubMedCrossRef

18.

Birben, E. et al., Oxidative stress and antioxidant defense, World Allergy Organ. J., 2012, vol. 5, no. 1, pp. 9–19.PubMedPubMedCentralCrossRef

19.

Himmelfarb, J., Relevance of oxidative pathways in the pathophysiology of chronic kidney disease, Cardiol. Clin., 2005, vol. 23, no. 3, pp. 319–330.PubMedCrossRef

20.

Nistala, R., Whaley-Connell, A., and Sowers, J.R., Redox control of renal function and hypertension, Antioxid. Redox Signal., 2008, vol. 10, no. 12, pp. 2047–2089.PubMedPubMedCentralCrossRef

21.

Tbahriti, H.F. et al., Effect of different stages of chronic kidney disease and renal replacement therapies on oxidant–antioxidant balance in uremic patients, Biochem. Res. Int., 2013, vol. 2013, p. 358985.PubMedPubMedCentralCrossRef

22.

Jankauskas, S.S. et al., The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy, Sci. Rep., 2017, vol. 7, p. 44430.PubMedPubMedCentralCrossRef

23.

Choksi, K.B. et al. Age-related increases in oxidatively damaged proteins of mouse kidney mitochondrial electron transport chain complexes, Free Radic. Biol. Med., 2007, vol. 43, no. 10, pp. 1423–1438.PubMedPubMedCentralCrossRef

24.

Qiao, X. et al., Mitochondrial pathway is responsible for aging-related increase of tubular cell apoptosis in renal ischemia/reperfusion injury, J. Gerontol. A Biol. Sci. Med. Sci., 2005, vol. 60, no. 7, pp. 830–839.PubMedCrossRef

25.

Serviddio, G. et al., Bioenergetics in aging: Mitochondrial proton leak in aging rat liver, kidney and heart, Redox Rep., 2007, vol. 12, no. 1, pp. 91–95.PubMedCrossRef

26.

Ferrucci, L. and Fabbri, E., Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty, Nat. Rev. Cardiol., 2018, vol. 15, no. 9, pp. 505–522.PubMedPubMedCentralCrossRef

27.

Shlipak, M.G. et al., Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency, Circulation, 2003, vol. 107, no. 1, pp. 87–92.PubMedCrossRef

28.

Kolios, G. and Moodley, Y., Introduction to stem cells and regenerative medicine, Respiration, 2013, vol. 85, no. 1, pp. 3–10.PubMedCrossRef

29.

Ferraro, F., Celso, C.L., and Scadden, D., Adult stem cells and their niches, Adv. Exp. Med. Biol., 2010, vol. 695, pp. 155–168.PubMedPubMedCentralCrossRef

30.

Andrianova, N.V. et al., Kidney cells regeneration: Dedifferentiation of tubular epithelium, resident stem cells and possible niches for renal progenitors, Int. J. Mol. Sci., 2019, vol. 20, no. 24, 6326.

31.

Oliver, J.A. et al., The renal papilla is a niche for adult kidney stem cells, J. Clin. Invest., 2004, vol. 114, no. 6, pp. 795–804.PubMedPubMedCentralCrossRef

32.

Patschan, D. et al., Normal distribution and medullary-to-cortical shift of Nestin-expressing cells in acute renal ischemia, Kidney Int., 2007, vol. 71, no. 8, pp. 744–754.PubMedCrossRef

33.

Mohyeldin, A., Garzón-Muvdi, T., and Quiñones-Hinojosa, A., Oxygen in stem cell biology: A critical component of the stem cell niche, Cell Stem Cell, 2010, vol. 7, no. 2, pp. 150–161.PubMedCrossRef

34.

Pannabecker, T.L. and Layton, A.T., Targeted delivery of solutes and oxygen in the renal medulla: Role of microvessel architecture, Am. J. Physiol. Renal Physiol., 2014, vol. 307, no. 6, pp. F649–F655.PubMedPubMedCentralCrossRef

35.

Huling, J. and Yoo, J.J., Comparing adult renal stem cell identification, characterization and applications, J. Biomed. Sci., 2017, vol. 24, no. 1, p. 32.PubMedPubMedCentralCrossRef

36.

Grange, C. et al., Protective effect and localization by optical imaging of human renal CD133+ progenitor cells in an acute kidney injury model, Physiol. Rep., 2014, vol. 2, no. 5, р. e12009.

37.

Smeets, B. et al., Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration, J. Pathol., 2013, vol. 229, no. 5, pp. 645–659.PubMedPubMedCentralCrossRef

38.

Gupta, S. et al., Isolation and characterization of kidney-derived stem cells, J. Am. Soc. Nephrol., 2006, vol. 17, no. 11, pp. 3028–3040.PubMedCrossRef

39.

Kitamura, S., Sakurai, H., and Makino, H., Single adult kidney stem/progenitor cells reconstitute three-dimensional nephron structures in vitro, Stem Cells, 2015, vol. 33, no. 3, pp. 774–784.PubMedCrossRef

40.

Abedin, M.J. et al., Identification and characterization of Sall1-expressing cells present in the adult mouse kidney, Nephron Exp. Nephrol., 2011, vol. 119, no. 4, pp. e75–e82.

41.

Lazzeri, E. et al., Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury, Nat. Commun., 2018, vol. 9, no. 1, p. 1344.PubMedPubMedCentralCrossRef

42.

Ward, H.H. et al., Adult human CD133/1(+) kidney cells isolated from papilla integrate into developing kidney tubules, Biochim. Biophys. Acta, 2011, vol. 1812, no. 10, pp. 1344–1357.PubMedPubMedCentralCrossRef

43.

Folmes, C.D.L. et al., Metabolic plasticity in stem cell homeostasis and differentiation, Cell Stem Cell, 2012, vol. 11, no. 5, pp. 596–606.PubMedPubMedCentralCrossRef

44.

Takubo, K. et al., Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells, Cell Stem Cell, 2013, vol. 12, no. 1, pp. 49–61.PubMedPubMedCentralCrossRef

45.

Piccoli, C. et al., Characterization of mitochondrial and extra-mitochondrial oxygen consuming reactions in human hematopoietic stem cells. Novel evidence of the occurrence of NAD(P)H oxidase activity, J. Biol. Chem., 2005, vol. 280, no. 28, pp. 26 467–26 476.CrossRef

46.

Sahin, E. and Depinho, R.A., Linking functional decline of telomeres, mitochondria and stem cells during ageing, Nature, 2010, vol. 464, no. 7288, pp. 520–528.PubMedPubMedCentralCrossRef

47.

Ahlqvist, K.J. et al., Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice, Cell Metab., 2012, vol. 15, no. 1, pp. 100–109.PubMedCrossRef

48.

Morganti, C. et al., Electron transport chain complex II sustains high mitochondrial membrane potential in hematopoietic stem and progenitor cells, Stem Cell Res., 2019, vol. 40, p. 101573.PubMedPubMedCentralCrossRef

49.

Sukumar, M. et al., Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy, Cell Metab., 2016, vol. 23, no. 1, pp. 63–76.PubMedCrossRef

50.

Prigione, A. et al., Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations, PLoS One, 2011, vol. 6, no. 11, p. e27352.PubMedPubMedCentralCrossRef

51.

Ito, K. et al., Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells, Nature, 2004, vol. 431, no. 7011, pp. 997–1002.PubMedCrossRef

52.

García-Prat, L. et al., FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age, Nat. Cell Biol., 2020, vol. 22, no. 11, pp. 1307–1318.PubMedCrossRef

53.

Yin, H., Price, F., and Rudnicki, M.A., Satellite cells and the muscle stem cell niche, Physiol. Rev., 2013, vol. 93, no. 1, pp. 23–67.PubMedPubMedCentralCrossRef

54.

García-Prat, L. and Muñoz-Cánoves, P., Aging, metabolism and stem cells: Spotlight on muscle stem cells, Mol. Cell. Endocrinol. 2017, vol. 445, pp. 109–117.PubMedCrossRef

55.

Sousa-Victor, P. et al., Geriatric muscle stem cells switch reversible quiescence into senescence, Nature, 2014, vol. 506, no. 7488, pp. 316–321.PubMedCrossRef

56.

Hwang, A.B. and Brack, A.S., Muscle stem cells and aging, Curr. Top. Dev. Biol., 2018, vol. 126, pp. 299–322.PubMedCrossRef

57.

Yamakawa, H. et al., Stem cell aging in skeletal muscle regeneration and disease, Int. J. Mol. Sci., 2020, vol. 21, no. 5, p. 1830.PubMedPubMedCentralCrossRef

58.

Katsimpardi, L. and Lledo, P.-M., Regulation of neurogenesis in the adult and aging brain, Curr. Opin. Neurobiol., 2018, vol. 53, pp. 131–138.PubMedCrossRef

59.

Isaev, N.K., Stelmashook, E.V., and Genrikhs, E.E., Neurogenesis and brain aging, Rev. Neurosci., 2019, vol. 30, no. 6, pp. 573–580.PubMedCrossRef

60.

Lewis-McDougall, F.C. et al., Aged-senescent cells contribute to impaired heart regeneration, Aging Cell, 2019, vol. 18, no. 3, p. e12931.PubMedPubMedCentralCrossRef

61.

Cianflone, E. et al., Targeting cardiac stem cell senescence to treat cardiac aging and disease, Cells, 2020, vol. 9, no. 6, p. 1558.PubMedPubMedCentralCrossRef

62.

Kozar, S. et al., Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas, Cell Stem Cell, 2013, vol. 13, no. 5, pp. 626–633.PubMedCrossRef

63.

Nalapareddy, K. et al., Canonical Wnt signaling ameliorates aging of intestinal stem cells, Cell Rep., 2017, vol. 18, no. 11, pp. 2608–2621.PubMedPubMedCentralCrossRef

64.

Schmitt, R. and Cantley, L.G., The impact of aging on kidney repair, Am. J. Physiol. Renal Physiol., 2008, vol. 294, no. 6, pp. F1265–F1272.PubMedCrossRef

65.

Miya, M. et al., Age-related decline in label-retaining tubular cells: Implication for reduced regenerative capacity after injury in the aging kidney, Am. J. Physiol. Renal Physiol., 2012, vol. 302, no. 6, pp. F694–F702.PubMedCrossRef

66.

Buyan, M.I. et al., Age-associated loss in renal Nestin-positive progenitor cells, Int. J. Mol. Sci., 2022, vol. 23, no. 19, p. 11015.PubMedPubMedCentralCrossRef

67.

Wiese, C. et al., Nestin expression—A property of multi-lineage progenitor cells?, Cell. Mol. Life Sci., 2004, vol. 61, nos. 19–20, pp. 2510–2522.PubMedCrossRef

68.

López-Otín, C. et al., The hallmarks of aging, Cell, 2013, vol. 153, no. 6, pp. 1194–1217.PubMedPubMedCentralCrossRef

69.

Jankauskas, S.S. et al., Aged kidney: Can we protect it? Autophagy, mitochondria and mechanisms of ischemic preconditioning, Cell Cycle, 2018, vol. 17, no. 11, pp. 1291–1309.PubMedPubMedCentralCrossRef

Titel: Age-Related Changes and Loss of Damage Resistance of Kidney Tissue: The Role of a Decrease in the Number of Kidney Resident Progenitor Cells
verfasst von: M. I. Buyan
N. V. Andrianova
E. Yu. Plotnikov
Publikationsdatum: 01.09.2023
Verlag: Pleiades Publishing
Erschienen in: Advances in Gerontology / Ausgabe 3/2023
Print ISSN: 2079-0570
Elektronische ISSN: 2079-0589
DOI: https://doi.org/10.1134/S2079057024600344

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Age-Related Changes and Loss of Damage Resistance of Kidney Tissue: The Role of a Decrease in the Number of Kidney Resident Progenitor Cells

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