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01.03.2023 | RESEARCH ARTICLES

Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues

verfasst von: V. V. Yanshole, M. V. Fomenko, L. V. Yanshole, N. A. Osik, E. Y. Radomskaya, D. V. Bulgin, Y. P. Tsentalovich

Erschienen in: Advances in Gerontology | Ausgabe 1/2023

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Abstract

The study is aimed at determining age-related changes in ocular tissues of crab-eating macaque (Macaca fascicularis). To this end, we measured the concentrations of a total of 71 major metabolites in aqueous humor, vitreous humor, and lens of two groups of animals, young (4-year-old, n = 6) and aged (21-year-old and 27-year-old, n = 2) macaques. Significant age-related changes were revealed for all three tissues. In the lens, the most significant changes were found for cytoprotective compounds – antioxidants, osmolytes, and molecular ultraviolet (UV) filters: the concentrations of these metabolites in the lenses of aged animals are much lower. The observed changes contribute to increased oxidative stress and predispose the lens to the development of cataracts. The majority of cytoprotective metabolites are synthetized in the lens epithelium. Findings of this work indicate that the observed age-related changes may be caused by the impairment of the lens epithelial cells leading to the increase of oxidative stress in the lens nucleus and developing of age-related cataracts.

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Bloemendal, H., de Jong, W., Jaenicke, R., Lubsen, N.H., Slingsby, C., and Tardieu, A., Ageing and vision: Structure, stability and function of lens crystallins, Prog. Biophys. Mol. Biol., 2004, vol. 86, pp. 407–485.CrossRefPubMed

Bron, A.J., Vrensen, G.F., Koretz, J., Maraini, G., and Harding, J.J., The ageing lens, Ophthalmologica, 2000, vol. 214, pp. 86–104.CrossRefPubMed

Sharma, K.K. and Santhoshkumar, P., Lens aging: Effects of crystallins, Biochim. Biophys. Acta, 2009, vol. 1790, pp. 1095–1108.CrossRefPubMedPubMedCentral

Michael, R. and Bron, A.J., The ageing lens and cataract: A model of normal and pathological ageing, Philos. Trans. R. Soc., B, 2011, vol. 366, pp. 1278–1292.

Truscott, R.J., Age-related nuclear cataract—oxidation is the key, Exp. Eye Res., 2005, vol. 80, pp. 709–725.CrossRefPubMed

Li, W.C., Kuszak, J.R., Dunn, K., Wang, R.R., Ma, W., Wang, G.M., Spector, A., Leib, M., Cotliar, A.M., Weiss, M., et al., Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals, J. Cell Biol., 1995, vol. 130, pp. 169–181.CrossRefPubMed

Ruotolo, R., Grassi, F., Percudani, R., Rivetti, C., Martorana, D., Maraini, G., and Ottonello, S., Gene expression profiling in human age-related nuclear cataract, Mol. Vision, 2003, vol. 9, pp. 538–548.

Yanshole, V.V., Yanshole, L.V., Snytnikova, O.A., and Tsentalovich, Y.P., Quantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract, Metabolomics, 2019, vol. 15, p. 29.CrossRefPubMed

Serebryany, E., Chowdhury, S., Woods, C.N., Thorn, D.C., Watson, N.E., McClelland, A.A., Klevit, R.E., and Shakhnovich, E.I., A native chemical chaperone in the human eye lens, eLife, 2022, vol. 11, p. e76923.CrossRefPubMedPubMedCentral

10.

Donaldson, A.E. and Lamont, I.L., Biochemistry changes that occur after death: Potential markers for determining post-mortem interval, PLoS One, 2013, vol. 8, p. e82011.ADSCrossRefPubMedPubMedCentral

11.

Zelentsova, E.A., Yanshole, L.V., Snytnikova, O.A., Yanshole, V.V., Tsentalovich, Y.P., and Sagdeev, R.Z., Post-mortem changes in the metabolomic compositions of rabbit blood, aqueous and vitreous humors, Metabolomics, 2016, vol. 12, p. 172.CrossRef

12.

Zelentsova, E.A., Yanshole, L.V., Melnikov, A.D., Kudryavtsev, I.S., Novoselov, V.P., and Tsentalovich, Y.P., Post-mortem changes in metabolomic profiles of human serum, aqueous humor and vitreous humor, Metabolomics, 2020, vol. 16, p. 80.CrossRefPubMed

13.

Zigler, J.S., Bodaness, R.S., Gery, I., and Kinoshita, J.H., Effects of lipid peroxidation products on the rat lens in organ culture: A possible mechanism of cataract initiation in retinal degenerative disease, Arch. Biochem. Biophys., 1983, vol. 225, pp. 149–156.CrossRefPubMed

14.

Yanshole, V.V., Snytnikova, O.A., Kiryutin, A.S., Yanshole, L.V., Sagdeev, R.Z., and Tsentalovich, Y.P., Metabolomics of the rat lens: A combined LC-MS and NMR study, Exp. Eye Res., 2014, vol. 125, pp. 71–78.CrossRefPubMed

15.

Tan, S.Z., Mullard, G., Hollywood, K.A., Dunn, W.B., and Bishop, P.N., Characterisation of the metabolome of ocular tissues and post-mortem changes in the rat retina, Exp. Eye Res., 2016, vol. 149, pp. 8–15.CrossRefPubMed

16.

Tsentalovich, Y.P., Yanshole, V.V., Yanshole, L.V., Zelentsova, E.A., Melnikov, A.D., and Sagdeev, R.Z., Seasonal variations and interspecific differences in metabolomes of freshwater fish tissues: Quantitative metabolomic profiles of lenses and gills, Metabolites, 2019, vol. 9, p. 264.CrossRefPubMedPubMedCentral

17.

Yanshole, V.V., Melnikov, A.D., Yanshole, L.V., Zelentsova, E.A., Snytnikova, O.A., Osik, N.A., Fomenko, M.V., Savina, E.D., Kalinina, A.V., Sharshov, K.A., et al., Animal metabolite database: Metabolite concentrations in animal tissues and convenient comparison of quantitative metabolomic data, Metabolites, 2023, vol. 13, p. 1088.CrossRefPubMedPubMedCentral

18.

Bova, L.M., Sweeney, M.H., Jamie, J.F., and Truscott, R.J., Major changes in human ocular UV protection with age, Invest. Ophthalmol. Vis. Sci., 2001, vol. 42, pp. 200–205.PubMed

19.

Babizhayev, M.A., Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: Disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract, Cell Biochem. Funct., 2011, vol. 29, pp. 183–206.CrossRefPubMed

20.

Skulachev, V.P., Anisimov, V.N., Antonenko, Y.N., Bakeeva, L.E., Chernyak, B.V., Erichev, V.P., Filenko, O.F., Kalinina, N.I., Kapelko, V.I., Kolosova, N.G., et al., An attempt to prevent senescence: A mitochondrial approach, Biochim. Biophys. Acta, Bioenerg., 2009, vol. 1787, pp. 437–461.CrossRef

Titel: Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues
verfasst von: V. V. Yanshole
M. V. Fomenko
L. V. Yanshole
N. A. Osik
E. Y. Radomskaya
D. V. Bulgin
Y. P. Tsentalovich
Publikationsdatum: 01.03.2023
Verlag: Pleiades Publishing
Erschienen in: Advances in Gerontology / Ausgabe 1/2023
Print ISSN: 2079-0570
Elektronische ISSN: 2079-0589
DOI: https://doi.org/10.1134/S2079057023600246

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