Association between attendance at outpatient follow-up appointments and blood pressure control among patients with hypertension

According to the World Health Organisation report, hypertension is the leading cause of morbidity and mortality in the world and is responsible for nine million deaths every year [1]. Despite the availability of different treatment options, the rate of blood pressure control remains suboptimal [2, 3]. In the United States of America alone, the cost associated with uncontrolled hypertension accounts for $131 billion annually [4]. Patients with hypertension, including those with controlled blood pressure, are twice as likely to develop cardiovascular complications as compared to the patients without hypertension [5]. The risk of stroke and ischemic cardiac events can be reduced to one third if the systolic blood pressure is controlled below 140 mmHg [6]. Effective control of blood pressure can only be achieved through lifelong care and regular follow-up [7, 8]. Regular treatment follow-up is an important component of effective disease management especially for long term conditions [9, 10]. For patients with hypertension, treatment follow-up provides an opportunity for healthcare practitioners to adjust patient’s treatment regimen, assess patient’s adherence to the therapy, monitor any adverse effects and improve patient’s understanding of disease management [11‐13]. The research has demonstrated that regular attendance at treatment follow-up appointments is associated with better treatment outcomes in patients with hypertension [8, 9, 14‐16]. Several interventions have been tested to improve follow-up care among patients with chronic diseases. These interventions include increased awareness among patients regarding the benefits of follow-up care, providing free medications, free transport vouchers, telephone/sms reminders and appointment assistance. All these interventions have shown positive effect on regularity in follow-up care among patients [12, 17‐19].

Although there is slight variation in recommendations for scheduling of treatment follow-up appointments among various hypertension treatment guidelines, all guidelines strongly recommend regular follow-up appointments to monitor treatment outcomes. The European Society of Hypertension (ESH) guidelines for management of arterial hypertension recommends frequent, at least once a month visit to a specialized healthcare facility until the optimal target blood pressure (BP) is achieved. Once the target BP is achieved a visit interval of few months is considered reasonable [20]. The American Heart Association (AHA) 2017 guidelines for prevention, detection, evaluation and management of high blood pressure in adults also recommend scheduling follow-up evaluation at monthly interval until target BP is achieved and should be reassessed every three to six months [21].

According to a recently published meta-analysis, the prevalence of hypertension in Pakistan was 26.4% [22]. The national health survey of Pakistan reported that only 50% of patients with hypertension in Pakistan were diagnosed and of those who were diagnosed, only 50% had ever received any treatment for hypertension [23]. Similarly the control rate of blood pressure was only 12.5% [23]. Both pharmacological and non-pharmacological interventions are required for optimal management of hypertension [24]. Despite of its importance, no data is available on the regularity of follow-up appointments, predictors of regularity in follow-up appointments and association between regular follow-up visits and blood pressure control among patients with hypertension in Pakistan. The purpose of this study was to assess the regularity in hospital follow-up appointments, determining factors predicting regularity in hospital follow-up visits and to find out the impact of regular treatment follow-up visits on blood pressure control among hypertensive patients in Pakistan.. This paper is part of larger study evaluating the predictors of blood pressure control in Pakistan [3].

A total of 662 patients with hypertension participated in the study. Of 662 patients, 315 (48%) were male and 346 (52%) were female. The mean (± S.D) age of participants was 54 (± 12) years. The mean (± S.D) duration of hypertension was 6 (± 6) years. The mean (± S.D) systolic blood pressure of participants was 148 mmHg (± 18) and mean (± S.D) diastolic blood pressure was 92 mmHg (± 11). The mean number of antihypertensive drugs used was 1.69 ± 0.7. Two hundred and sixty (39%) participants were obese. Two hundred and eighty-nine (44%) participants were using single antihypertensive agent and, 253 (38%) participants were entitled to free medical care. Two hundred and ninety (44%) participants had at least one co-morbidity. The prevalence of diabetes among participants was 15% 8% of participants had coronary artery disease [CAD], 1% patients had congestive heart failure [CHF] and 21% of participants had hyperlipidemia. The participants’ demographic characteristics are presented in Table 1. Less than half of the patients (41%) were regular in attending follow-up visits. Similarly, in terms of healthcare setting, the number of patients who were regular in attending their follow-up appointments in tertiary care, secondary care and primary care setting were 118 (38%), 123 (61%) and 33 (22%) respectively. (Table 2).

Out of 662 participants, 253 patients were entitled to free medical care. Of the patients who were entitled to free medical care, 150 (58%) participants regularly attended treatment follow-up appointments. Whereas the patients who were not entitled to free medical care, only 124 (31%) participants attended regular treatment follow-up appointments (P = 0.0001) (Table 2).

The results of binary regression analysis found that gender, age, higher education, entitlement status, treatment duration, number of medications, presence of co-morbidity, medication adherence and blood pressure control were significantly associated with regularity in treatment follow-up appointments. Similarly marital status, body mass index (BMI) and profession had no significant association with regularity in treatment follow-up visits. (Table 3).

For factors associated with treatment follow-up regularity, the results of binary regression analysis showed that males were 1.7 times more likely to regularly attend follow-up meetings compared to females (OR 1.720 [95% CI 1.259–2.3]). The participants aged ≥ 60 years of age were 1.5 times more likely to be regular in treatment follow-up visits than participants who were under 60 years of age (OR 1.462 [95% CI 1.059–2.020]). The participants who were entitled to free medical care were approximately three times more likely to attend follow-up appointments regularly compared with patients who were not entitled to free medical care (OR 3.166 [95% CI 2.284–4.388]). Patients with a co-morbidity were 3.2 times more likely to be regular in treatment follow-up visits than the patients without any co-morbidity (OR 3.214 [95% CI 2.248–4.593]). Patients with good medication adherence were approximately six times more likely to be regular in attending treatment follow-up appointments compared to patients with poor medication adherence (OR 6.231 [95% CI 4.264–9.106]) (Table 3).

Similarly, for blood pressure control the results of binary regression analysis showed that treatment follow-up regularity, age, number of anti-hypertensive medications and medication adherence had significant association with blood pressure control. On the other hand, gender, body mass index (BMI), level of education, employment status, marital status, entitlement status, treatment duration and presence of co-morbidity had no significant association with controlled blood pressure. The results of binary regression analysis further revealed that odds of controlled blood pressure in patients who were regular in their treatment follow-up visits were 1.5 times higher than the patients who were irregular in their treatment follow-up visits (OR 1.561 [95% CI 1.102–2.211]). Similarly, the odds of controlled blood pressure were 1.08 times higher in males as compared to females (OR 1.08 [95% CI 0.753–1.543]), being 60 years of age and above (OR 1.638 [95% CI 1.168–2.297]). being unmarried/divorced/widowed (OR 1.257 [95% CI 0.757–2.087]), being university graduate (OR 1.229 [95% CI 0.730–2.068]), being normal weight (OR 1.05 [95% CI 0.743–1.482), being an officer (OR 1.462 [95% CI 0.661–3.236]), being entitled to free medical care (OR 1.210[95% CI 0.858–1.707]), more than 05 years of treatment duration (OR 1.246[95% CI 0.875–1.776]), having co-morbidity (OR 1.072 [95% CI 0.733–1.568]), being adherent to prescribed pharmacotherapy (OR 2.720[95% CI 1.890–3.915]). On the contrary the odds of controlled blood pressure decrease with every unit increase in no. of prescribed anti-hypertensive medications (OR 0.689[95% CI 0.538–0.882]). (Table 4).

The aim of this study was to assess the regularity in attending treatment follow-up appointments, factors determining regularity in follow-up appointments and to evaluate the impact of regular treatment follow-up visits on treatment outcomes among patients with hypertension in Islamabad, Pakistan. Overall, attendance at treatment follow-up visits was poor. Furthermore, positive association between regular treatment follow-up and controlled blood pressure was observed among hypertension patients attending different healthcare settings. However, patients entitled to free medical care were more likely to attend treatment follow-up visits compared to the patients who had to pay from their own pocket.

Pakistan healthcare system consists of three tiers i.e. primary, secondary and tertiary healthcareand is run by both public and private sectors. Tertiary care hospitals are the teaching hospitals located in big cities of the country [23, 33]. Free healthcare coverage is available to only 27% of the population which mostly include government employees and members of the armed forces of Pakistan. They either receive free medicines and other healthcare services from the hospital or through reimbursement in case a medicine or a healthcare service is not available in the hospital. The remaining 73% population pay from their pockets for the healthcare services [34].

There is scarcity of research investigating the association between regularity in treatment follow-up appointments and blood pressure control not only in Pakistan but also in the South Asian region. In line with previous findings, we found a positive association between regular treatment follow-up and controlled blood pressure [8, 9, 15, 16, 35‐37]. This positive association between regularity in treatment follow-up and controlled blood pressure could be due to the fact that the regular treatment follow-up visits provides an opportunity to healthcare providers to educate patients about their disease and drug therapy, optimize their therapy and to monitor treatment outcomes. There is a need to develop policies aiming at facilitating the patients in their treatment follow-up appointments to ensure better treatment outcomes.

Our results also suggest that entitlement to free medical care was significantly associated with regularity in treatment follow-up appointments. This finding is also consistent with previously reported studies [29, 38]. Unaffordability of healthcare services is the main issue in many lower-middle and low-income countries including Pakistan [39‐41].. Health authorities should ensure that access to basic and specialised healthcare services is affordable for all the citizens.

A number of factors associated with regularity of treatment follow-up were identified in this study. It was observed that male patients were more regular in attending treatment follow-up appointments compared to the female patients. Gender differences in attending follow-up appointments have been reported for other disease conditions as well [42, 43]. However, studies conducted in the United Kingdom and Canada have reported that female patients were more likely to attend treatment follow-up visits compared to their male counterparts [14, 44]. The differences in the findings can be explained by the differences in cultural and social values. In Pakistan, females often need a male guardian to accompany them to the hospital and their attendance at. follow-up appointments depend on the availability of an accompanying person and this may lead to the less regularity in treatment follow-up among females. Female only clinics can potentially help overcome this barrier.

Age was found to be significantly associated with regularity in treatment follow-up visits. Previously, mixed results have been reported in literature for the association between age and regular attendance at follow-up appointments [14, 42‐45]. Increased disease severity or the presence of other co-morbidities among old age patients may encourage elderly patients to regularly attend treatment follow-up appointments. However, some studies found negative correlation between age and regularity in treatment follow-up [46]. This negative correlation may be due to memory loss, non-availability of any caregiver or deteriorated health condition of the patient.

Our study found that patients with university level qualification were more likely to attend treatment follow-up visits. The results of our study are in line with previously conducted studies which also found a significant correlation between level of education and regularity in treatment follow-up visits [29, 47, 48]. Better disease knowledge and awareness about potential complications among university graduates may explain higher likelihood to attend treatment follow-up visits.

In line with the findings of a pervious study [46], we found significant positive correlation between the number of medications used and the regularity in treatment follow-up visits. A higher number of medications often means greater disease severity which could motivate patients to regularly attend their follow-up appointments. Similarly, in line with previous studies [14, 42], we found significant correlation between the presence of co-morbidity and regularity in treatment follow-up visits. Hypertension is often an asymptomatic disease so the patients do not feel need for regular treatment follow-up visits but the patients with any co-morbidity may perceive themselves sicker and seek medical help more frequently. Our study reported a very strong association between the medication adherence and regularity in treatment follow-up visits. This result is in line with previously conducted studies [49‐51]. Similarly the result of our study suggests the significant correlation between the controlled blood pressure and regularity in treatment follow-up visits. Regularity in treatment follow-up visits increases the likelihood of controlled blood pressure in patients with hypertension. In every subgroup the patients who were regular in treatment follow-up visits had better rate of blood pressure control as compared to the patients who were regular in their treatment follow-up visits. These results are in line with the findings of previously conducted studies [8, 9, 14, 52]. This increased blood pressure control could be possibly because the regular follow-up visits provide healthcare practitioners an opportunity to adjust the treatment regimen, educate the patient and assess the patient’s adherence to prescribed pharmacotherapy, resulting in better treatment outcomes. Lastly high medication adherence was significantly associated with high rate of blood pressure control. The results of our study are self-explanatory and in line with a number of previous research studies than showed better treatment outcomes in patients with high medication adherence [3, 35, 53, 54].

Regularity in treatment follow-up appointments was poor in patients with hypertension attending different healthcare settings in Islamabad, Pakistan. There is an association between blood pressure control and regularity in attending treatment follow-up appointments. On the basis of determining factors identified in our study, targeted interventions should be designed and implemented for better therapeutic outcomes.