Background
Methods
Study population
Image acquisition
Image analysis
Statistical analysis
Results
Study population
Characteristic | Derivation cohort (n = 200)a
| Validation cohort (n = 200)a
|
p-value |
---|---|---|---|
Age (years) | 51 ± 18 | 48 ± 17 | 0.14 |
Female sex, n (%) | 100 (50%) | 100 (50%) | 1.0 |
Height (cm) | 173 ± 14 | 174 ± 10 | 0.44 |
Weight (kg) | 77 ± 16 | 78 ± 18 | 0.79 |
BSA (m2) | 1.9 ± 0.3 | 1.9 ± 0.2 | 0.95 |
LVEDV (ml) | 180 ± 63 | 183 ± 63 | 0.56 |
LVEDVI (ml/m2) | 94 ± 29 | 95 ± 32 | 0.61 |
LVESV (ml) | 91 ± 57 | 88 ± 57 | 0.81 |
LVESVI (ml/m2) | 47 ± 28 | 46 ± 29 | 0.95 |
LVSV (ml) | 89 ± 27 | 95 ± 25 | 0.02* |
LVSVI (ml/m2) | 47 ± 14 | 50 ± 11 | 0.01* |
LVEF (%) | 52 ± 12 | 54 ± 11 | 0.06 |
LVM (g) | 138 ± 46 | 137 ± 53 | 0.75 |
LVMI (g/m2) | 71 ± 19 | 72 ± 23 | 0.95 |
ECV (%) | 28 ± 4 | 28 ± 4 | 0.51 |
Hematocrit (%) | 40 ± 4 | 40 ± 5 | 0.71 |
Septal wall thickness (mm) | 10 ± 2 | 10 ± 2 | 0.45 |
Myocardial T1 (ms) | 1030 ± 43 | 1023 ± 45 | 0.07 |
Mean blood R1 (ms−1) | 0.00064 ± 0.00004 | 0.00064 ± 0.00004 | 0.49 |
Mean blood R1* (ms−1) | 0.00061 ± 0.00005 | 0.00061 ± 0.00005 | 0.98 |
Characteristic, females (n = 200) | Derivation cohort (n = 100)a
| Validation cohort (n = 100)a
|
p-value |
---|---|---|---|
Age (years) | 52 ± 18 | 49 ± 17 | 0.21 |
Female sex, n (%) | 100 (100%) | 100 (100%) | 1.0 |
Height (cm) | 165 ± 8 | 167 ± 7 | 0.17 |
Weight (kg) | 69 ± 14 | 70 ± 16 | 0.89 |
BSA (m2) | 1.8 ± 0.2 | 1.8 ± 0.2 | 0.77 |
LVEDV (ml) | 157 ± 52 | 159 ± 49 | 0.48 |
LVEDVI (ml/m2) | 89 ± 28 | 89 ± 26 | 0.47 |
LVESV (ml) | 91 ± 57 | 88 ± 57 | 0.81 |
LVESVI (ml/m2) | 47 ± 28 | 46 ± 29 | 0.95 |
LVSV (ml) | 78 ± 21 | 83 ± 20 | 0.65 |
LVSVI (ml/m2) | 45 ± 11 | 47 ± 11 | 0.16 |
LVEF (%) | 53 ± 12 | 54 ± 11 | 0.44 |
LVM (g) | 110 ± 26 | 112 ± 42 | 0.41 |
LVMI (g/m2) | 62 ± 14 | 64 ± 22 | 0.49 |
ECV (%) | 29 ± 4 | 29 ± 3 | 0.72 |
Hematocrit (%) | 38 ± 4 | 38 ± 5 | 0.93 |
Septal wall thickness (mm) | 9 ± 2 | 9 ± 3 | 0.45 |
Myocardial T1 (ms) | 1046 ± 41 | 1040 ± 37 | 0.29 |
Mean blood R1 (ms−1) | 0.00062 ± 0.00003 | 0.00062 ± 0.00003 | 0.58 |
Mean blood R1* (ms−1) | 0.00059 ± 0.00004 | 0.00054 ± 0.00005 | 0.95 |
Characteristic, males (n = 200) | Derivation cohort (n = 100) | Validation cohort (n = 100) |
p-value |
---|---|---|---|
Age (years) | 49 ± 18 | 47 ± 18 | 0.40 |
Female sex, n (%) | 0 (0%) | 0 (0%) | 1.0 |
Height (cm) | 181 ± 14 | 180 ± 8 | 0.81 |
Weight (kg) | 86 ± 14 | 85 ± 16 | 0.84 |
BSA (m2) | 2.0 ± 0.3 | 2.1 ± 0.2 | 0.77 |
LVEDV (ml) | 204 ± 64 | 207 ± 68 | 0.67 |
LVEDVI (ml/m2) | 99 ± 29 | 100 ± 36 | 0.96 |
LVESV (ml) | 103 ± 62 | 101 ± 64 | 0.71 |
LVESVI (ml/m2) | 50 ± 29 | 49 ± 34 | 0.56 |
LVSV (ml) | 99 ± 27 | 106 ± 24 | 0.047* |
LVSVI (ml/m2) | 49 ± 16 | 52 ± 11 | 0.02* |
LVEF (%) | 51 ± 12 | 54 ± 11 | 0.06 |
LVM (g) | 166 ± 45 | 162 ± 51 | 1.0 |
LVMI (g/m2) | 80 ± 20 | 80 ± 21 | 0.78 |
ECV (%) | 27 ± 3 | 27 ± 4 | 0.60 |
Hematocrit (%) | 42 ± 4 | 43 ± 4 | 0.41 |
Septal wall thickness (mm) | 11 ± 2 | 11 ± 2 | 0.58 |
Myocardial T1 (ms) | 1015 ± 39 | 1005 ± 46 | 0.10 |
Mean blood R1 (ms−1) | 0.00066 ± 0.00004 | 0.00066 ± 0.00003 | 0.57 |
Mean blood R1* (ms−1) | 0.00063 ± 0.00004 | 0.00063 ± 0.00004 | 0.98 |
Myocardial T1 correlation
Characteristic | Univariate r | Multivariate beta | Multivariate beta, final model | Global R2
|
---|---|---|---|---|
Derivation cohort (n = 200) | 0.26 (p < 0.001) | |||
Hematocrit (%) | −0.37 (p < 0.001) | 0.00 (p = 0.98) | ||
Mean blood R1 (ms-1) | −0.45 (p < 0.001) | −0.28 (p = 0.003) | −0.28 (p = 0.001) | |
Mean blood R1* (ms-1) | −0.45 (p < 0.001) | −0.28 (p = 0.002) | −0.28 (p = 0.001) | |
Septal wall thickness (mm) | 0.07 (p = 0.33) | - | - | |
Validation cohort (n = 200) | ||||
Hematocrit (%) | −0.39 (p < 0.001) | |||
Mean blood R1 (ms-1) | −0.49 (p < 0.001) | |||
Mean blood R1* (ms-1) | −0.44 (p < 0.001) | |||
Septal wall thickness (mm) | 0.07 (p = 0.32) | - | - |