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European Archives of Paediatric Dentistry

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20.05.2022 | Systematic Review

Clinical and radiographic comparison of Biodentine and Formocresol: an updated meta-analysis with trial sequential analysis

verfasst von: Parsa Firoozi, Bahareh Nazemi Salman, Naser Aslaminabadi

Erschienen in: European Archives of Paediatric Dentistry | Ausgabe 6/2022

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Abstract

Purpose

This meta-analysis aimed to compare the clinical and radiographic success rate of Biodentine as an alternative to Formocresol to provide a critical appraisal of the available literature and evidence-based conclusion as well as update the previous systematic review.

Methods

MEDLINE, CENTRAL, Web of Science, Scopus, and Google Scholar databases were searched up to 20 October 2021 to identify RCTs evaluating pulpotomy with Biodentine/Formocresol in carious primary molars among children ≤ 10 years old. The risk of bias was assessed using the Cochrane RoB-2 tool. RRs and corresponding 95% CIs were calculated to pool results that RR ˃ 1 indicated a higher success rate in the Biodentine group and RR < 1 indicated a higher success rate in the Formocresol group. Heterogeneity was calculated using the I² and τ² statistics. In addition, trial sequential analysis was performed to adjust results for type I and type II errors and evaluate power of the meta-analysis.

Results

Nine RCTs were identified and eight RCTs were included in the meta-analysis and trial sequential analysis. The obtained evidence showed no significant difference between Biodentine and Formocresol in terms of clinical efficacy. However, considering the radiographic success rate the results of the meta-analysis and trial sequential analysis significantly favoured Biodentine.

Conclusion

Within the limitations of the present review and based on the retrieved findings it has been clearly shown that Biodentine is superior compared to Formocresol in terms of radiographic success rate with firm evidence in this regard. Although the performed meta-analysis showed no significant clinical difference between Biodentine and Formocresol, however, trial sequential analysis revealed a lack of firm evidence in this regard.

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Titel: Clinical and radiographic comparison of Biodentine and Formocresol: an updated meta-analysis with trial sequential analysis
verfasst von: Parsa Firoozi
Bahareh Nazemi Salman
Naser Aslaminabadi
Publikationsdatum: 20.05.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Paediatric Dentistry / Ausgabe 6/2022
Print ISSN: 1818-6300
Elektronische ISSN: 1996-9805
DOI: https://doi.org/10.1007/s40368-022-00715-9

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Clinical and radiographic comparison of Biodentine and Formocresol: an updated meta-analysis with trial sequential analysis

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Results

Conclusion

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