Introduction
Methods and materials
Study design and setting
Data collection and study performing
Statistical analysis
Ethical considerations
Results
Variables | Unit/Type | hyperuricemia Group (Mean ± SD) (Frequency/Percentage) | normal uric acid Group (Mean ± SD) (Frequency/Percentage) | Total (Mean ± SD) (Frequency/Percentage) | P-value |
---|---|---|---|---|---|
Gender | Female | 26/32.9 | 8/38.1 | 34/34 | 0.656 |
Male | 53/67.1 | 13/61.9 | 66/66 | ||
Age | years | 64.62 ± 14.37 | 58.95 ± 15.76 | 63.43 ± 14.78 | 0.154 |
Height | cm | 164.13 ± 7.16 | 167.84 ± 8.49 | 167.27 ± 8.35 | 0.243 |
Weight | kg | 74.5 ± 12.75 | 63.88 ± 17.12 | 72.87 ± 13.87 | 0.026 |
Male BMI | Normal | 10/33.3 | 3/60.0 | 13/37.1 | 0.253 |
High | 20/66.7 | 2/40.0 | 22/62.9 | 0.253 | |
Female BMI | Normal | 6/42.9 | 3/100.0 | 9/52.9 | 0.072 |
High | 8/57.1 | 0/0 | 8/47.1 | 0.072 | |
HTN | - | 47/59.5 | 12/57.1 | 59/59 | 0.846 |
Diabetes | - | 32/40.5 | 7/33.3 | 39/39 | 0.549 |
Dyslipidemia | - | 9/11.4 | 2/9.5 | 11/11 | 0.808 |
CAD | - | 34/43 | 5/23.8 | 39/39 | 0.108 |
HF | - | 62/78.5 | 15/71.4 | 77/77 | 0.495 |
CKD | - | 16/20.3 | 1/4.8 | 17/17 | 0.093 |
Smoking status | - | 28/35.4 | 9/42.9 | 37/37 | 0.532 |
Alcohol consuming | - | 2/2.5 | 0/0 | 2/2 | 0.461 |
Drug abuse | - | 1/1.3 | 4/19 | 5/5 | 0.001 |
Employment status | Employed | 39/49.4 | 9/42.9 | 48/48 | 0.178 |
unemployed | 40/50.6 | 12/57.1 | 52/52 |
Variables | hyperuricemia Group (Frequency/Percentage) | normal uric acid Group (Frequency/Percentage) | Total (Frequency/Percentage) | P-value |
---|---|---|---|---|
Failure to use medications | 0/0 | 1/4.8 | 1/1 | 0.336 |
ACS | 26/32.9 | 6/28.6 | 32/32 | |
Anemia | 1/1.3 | 1/4.8 | 2/2 | |
Renal failure | 7/8.9 | 1/4.8 | 8/8 | |
Arrhythmia | 20/25.3 | 4/19 | 24/24 | |
Unknown causes | 25/31.6 | 8/38.1 | 33/33 |
Variables | Unit/Type | hyperuricemia Group (Mean ± SD) (Frequency/Percentage) | normal uric acid Group (Mean ± SD) (Frequency/Percentage) | Total (Mean ± SD) (Frequency/Percentage) | P-value |
---|---|---|---|---|---|
Blood pressure | Systolic | 121.37 ± 25.83 | 126.62 ± 24.47 | 122.47 ± 25.52 | 0.430 |
Diastolic | 77.71 ± 17.15 | 82.48 ± 20.85 | 78.71 ± 17.98 | ||
Heart rate | Beats/min | 82.65 ± 16.54 | 89.86 ± 17.73 | 84.18 ± 16.97 | 0.489 |
Body temperature | Celsius | 36.09 ± 3.33 | 36.65 ± 0.48 | 36.21 ± 2.98 | 0.196 |
SpO2 | Percent | 91.65 ± 5.1 | 92.57 ± 3.7 | 91.84 ± 4.84 | 0.102 |
HF type | Ischemic | 36/45.6 | 7/33.3 | 43/43 | 0.683 |
Non-ischemic | 43/54.4 | 14/66.7 | 57/57 | 0.314 | |
AHF type | ADHF | 63/79.7 | 15/71.4 | 78/78 | 0.413 |
DNHF | 16/20.3 | 6/28.6 | 22/22 | ||
HF stage | C | 53/70.7 | 15/75 | 68/71.6 | 0.703 |
D | 22/29.3 | 5/25 | 27/28.4 | ||
NYHA | III | 36/45.6 | 9/42.9 | 45/45 | 0.992 |
IV | 19/24.1 | 5/23.8 | 24/24 | ||
Dyspnea | - | 72/91.1 | 16/76.2 | 88/88 | 0.061 |
Orthopnea | - | 20/25.3 | 4/19 | 24/24 | 0.550 |
Paroxysmal nocturnal dyspnea | - | 4/5.1 | 1/4.8 | 5/5 | 0.955 |
Chest pain | - | 15/19 | 5/23.8 | 20/20 | 0.623 |
Fatigue | - | 14/17.7 | 4/19 | 18/18 | 0.888 |
Tachycardia | - | 12/15.2 | 2/9.5 | 14/14 | 0.506 |
Edema | - | 50/50.6 | 5/23.8 | 45/45 | 0.028 |
GI tract symptoms | - | 16/20.3 | 4/19 | 20/20 | 0.902 |
Ascites | - | 10/12.7 | 0/0 | 10/10 | 0.086 |
Elevated JVP | - | 11/13.9 | 1/4.8 | 12/12 | 0.251 |
Time | Medications | Group A (Frequency/Percentage) | Group B (Frequency/Percentage) | Total (Frequency/Percentage) | P-value |
---|---|---|---|---|---|
Medications used before hospitalization | Calcium channel blockers | 3/4.4 | 2/11.1 | 5/5.8 | 0.280 |
Furosemide | 42/61.8 | 7/38.9 | 49/57 | 0.081 | |
ACE inhibitors | 18/26.5 | 3/16.7 | 21/24.4 | 0.389 | |
Angiotensin receptor blockers | 23/33.3 | 4/22.2 | 27/31 | 0.364 | |
Beta-blockers | 40/58.8 | 4/22.2 | 44/51.2 | 0.006 | |
Spironolactone | 24/35.3 | 3/16.7 | 27/31.4 | 0.130 | |
Digoxin | 24/35.3 | 4/22.2 | 28/32.6 | 0.293 | |
Nitrate-based vasodilators | 7/10.3 | 1/5.6 | 8/9.3 | 0.538 | |
Medications used during hospitalization | ACE inhibitor | 58/73.4 | 11/52.4 | 69/69 | 0.064 |
Angiotensin receptor blockers | 2/2.5 | 0/0 | 2/2 | 0.461 | |
Inotrope | 24/30.8 | 3/14.3 | 27/27 | 0.132 | |
Nitrate-based vasodilators | 9/11.4 | 0/0 | 9/9 | 0.105 | |
Spironolactone | 58/73.4 | 17/22.7 | 75/75 | 0.478 | |
Beta-blockers | 69/87.3 | 16/76.2 | 85/85 | 0.203 | |
Allopurinol | 2/2.5 | 0/0 | 2/2 | 0.461 | |
Digoxin | 30/38.5 | 2/6.3 | 32/32 | 0.012 |
Variables | hyperuricemia Group (Mean ± SD) | normal uric acid Group (Mean ± SD) | Total (Mean ± SD) | P-value |
---|---|---|---|---|
WBC | 9576 ± 4099 | 8871 ± 4002 | 9407 ± 4064 | 0.376 |
Hemoglobin | 13.02 ± 2.85 | 12.97 ± 2.40 | 13.01 ± 2.74 | 0.869 |
Hematocrit | 39.45 ± 7.70 | 39.63 ± 6.84 | 39.49 ± 7.47 | 0.784 |
Platelet | 211,029 ± 83,503 | 228,990 ± 102,344 | 215,315 ± 88,073 | 0.484 |
BUN | 37.17 ± 22.15 | 19.58 ± 8.27 | 33.48 ± 21.27 | < 0.001 |
Admission creatinine | 1.99 ± 1.16 | 1.31 ± 0.91 | 1.85 ± 1.15 | 0.002 |
Discharged creatinine | 1.87 ± 0.21 | 1.05 ± 0.23 | 1.86 ± 1.74 | 0.001 |
Admission eGFR | 44.03 ± 21.33 | 68.80 ± 39.06 | 47.84 ± 25.97 | 0.082 |
Discharged eGFR | 44.11 ± 23.92 | 79.65 ± 47.84 | 49.68 ± 31.17 | 0.033 |
eGFR changes | 10.49 ± 2.91 | 28.08 ± 16.21 | 2.83 ± 15.22 | 0.521 |
Natrium [Na] | 137.22 ± 5.43 | 139.38 ± 3.44 | 137.68 ± 5.13 | 0.081 |
Potassium [K] | 4.39 ± 0.75 | 4.24 ± 0.51 | 4.36 ± 0.71 | 0.709 |
Uric acid | 9.43 ± 1.93 | 5.22 ± 1.31 | 8.55 ± 2.50 | < 0.001 |
Blood sugar | 179.90 ± 141.21 | 118.83 ± 95.52 | 167.89 ± 135 | 0.022 |
LDL | 98.67 ± 72.49 | 74.53 ± 102.50 | 99.61 ± 72.35 | 0.636 |
HDL | 35.52 ± 9.29 | 40 ± 11 | 36.64 ± 9.85 | 0.155 |
Triglyceride [TG] | 109.19 ± 56.07 | 148.65 ± 136.41 | 85.24 ± 119.51 | 0.654 |
AST | 89 ± 167.62 | 85.97 ± 179.55 | 86.61 ± 176.18 | 0.556 |
ALT | 83.46 ± 189.25 | 81.83 ± 177.32 | 83.13 ± 185.91 | 0.620 |
ALP | 246.91 ± 114.55 | 317.82 ± 377.49 | 260.77 ± 194.52 | 0.401 |
Total bilirubin | 1.49 ± 1.18 | 0.95 ± 0.41 | 1.38 ± 1.09 | 0.087 |
ESR | 42.47 ± 42.49 | 33.80 ± 20.64 | 4.40 ± 38.37 | 0.988 |
CRP | 0.97 ± 1.31 | 1.11 ± 1.57 | 1 ± 1.37 | 0.903 |
Variables | Route | hyperuricemia Group (Mean ± SD) (Frequency/Percentage) | Natural uric acid Group (Mean ± SD) (Frequency/Percentage) | Total (Mean ± SD) (Frequency/Percentage) | P-value |
---|---|---|---|---|---|
Furosemide | Total | 645.52 ± 372.36 | 473.26 ± 391.45 | 609.95 ± 380.69 | 0.061 |
Oral | 136.44 ± 181.97 | 164.21 ± 203.59 | 142.17 ± 185.81 | 0.582 | |
IV | 577.30 ± 400.63 | 391.16 ± 402.47 | 538.86 ± 405.92 | 0.045 | |
Thiazides | Oral | 4/5.1 | 0 | 4/4 | 0.576 |
acetazolamide | Oral | 2/2.5 | 0 | 22/22 | 0.999 |
Variables | Route | hyperuricemia Group (Mean ± SD) (Frequency/Percentage) | Natural uric acid Group (Mean ± SD) (Frequency/Percentage) | Total (Mean ± SD) (Frequency/Percentage) | P-value | |
---|---|---|---|---|---|---|
Male | Furosemide | Oral | 132.07 ± 180.30 | 129.09 ± 230.36 | 131.56 ± 187.77 | 0.685 |
IV | 570.83 ± 376.48 | 349.09 ± 226.86 | 532.71 ± 363.69 | 0.73 | ||
Thiazides acetazolamide | Oral | 570.83 ± 36.40 | 349.10 ± 226.87 | 5.38 ± 33.21 | 0.233 | |
Oral | 36.363 ± 212.01 | 0.0 ± 0.0 | 30.30 ± 193.72 | 0.252 | ||
Female | Furosemide | Oral | 139.09 ± 184.18 | 266.66 ± 146.78 | 166.42 ± 182.25 | 0.562 |
IV | 601.86 ± 492.99 | 373.33 ± 510.56 | 552.89 ± 496.41 | 0.881 | ||
Thiazides acetazolamide | Oral | 25.0 ± 85.97 | 0 | 19.35 ± 76.02 | 0.107 | |
Oral | 0 | 0 | 0 | - |
Variables | Type | hyperuricemia Group (Frequency/Percentage) | normal uric acid Group (Frequency/Percentage) | Total (Frequency/Percentage) | P-value |
---|---|---|---|---|---|
Rhythm | Normal sinus | 51/64.6 | 15/71.4 | 66/66 | 0.801 |
Ventricular tachycardia | 1/1.3 | 0/0 | 1/1 | ||
Atrial fibrillation | 25/31.6 | 5/23.8 | 30/30 | ||
Pacemaker | 2/2.5 | 1/4.8 | 3/3 | ||
Wide QRS | - | 7/8.9 | 3/14.3 | 10/10 | 0.461 |
LBBB | - | 14/17.7 | 1/4.8 | 15/15 | 0.139 |
RBBB | - | 5/6.3 | 5/23.8 | 10/10 | 0.018 |
Q wave | - | 14/17.7 | 1/4.8 | 15/15 | 0.139 |
ST segment changes | - | 12/15.2 | 2/9.5 | 14/14 | 0.506 |
Variables | Unit/Type | hyperuricemia Group (Mean ± SD) (Frequency/Percentage) | normal uric acid Group (Mean ± SD) (Frequency/Percentage) | Total (Mean ± SD) (Frequency/Percentage) | P-value |
---|---|---|---|---|---|
LVEF | % | 19.71 ± 10.07 | 27.50 ± 11.79 | 21.34 ± 10.86 | 0.011 |
LVED | mm | 57.4 ± 29.99 | 52.61 ± 10.18 | 56.36 ± 10.16 | 0.052 |
LVES | mm | 48.50 ± 9.42 | 35.86 ± 5.58 | 45.22 ± 10.20 | 0.001 |
LAVI1 | mm | 42.69 ± 12.43 | 26.33 ± 7.44 | 38.84 ± 13.32 | 0.015 |
RAA | mm | 18.2 ± 13.12 | 11.48 ± 4.30 | 16.44 ± 4.52 | 0.005 |
RVDD | mm | 37.68 ± 6.57 | 33.80 ± 5.94 | 36.82 ± 6.60 | 0.049 |
TAPSE2 | mm | 16.41 ± 4.83 | 17.68 ± 2.58 | 16.71 ± 4.42 | 0.102 |
Mitral regurgitation | Absence | 3/4.5 | 1/5.9 | 4/4.8 | 0.694 |
Mild | 13/19.4 | 5/29.4 | 18/21.4 | ||
Moderate | 36/53.7 | 9/52.9 | 45/53.6 | ||
Severe | 15/22.4 | 2/11.8 | 17/20.2 | ||
Tricuspid regurgitation | Absence | 5/7.6 | 0/0 | 5/6 | 0.123 |
Mild | 14/21.2 | 8/44.4 | 22/26.2 | ||
Moderate | 43/65.2 | 8/44.4 | 51/60.7 | ||
Severe | 4/6.1 | 2/11.1 | 6/7.1 |
Variables | Serum uric acid level | Admission duration | ||
---|---|---|---|---|
r | P-value | r | P-value | |
Serum uric acid level | - | - | -0.122 | 0.230 |
Admission duration | -0.122 | 0.230 | - | - |
Total furosemide | 0.291 | 0.005 | 0.612 | < 0.001 |
Oral furosemide | -0.174 | 0.098 | 0.391 | < 0.001 |
IV furosemide | 0.313 | 0.002 | 0.485 | < 0.001 |
Thiazides | 0.154 | 0.063 | 0.117 | 0.178 |
Acetazolamide | 0.084 | 0.313 | 0.124 | 0.153 |
Furosemide before hospitalization | 0.282 | 0.008 | -0.097 | 0.375 |
Age | 0.169 | 0.093 | 0.025 | 0.804 |
Weight | 0.3 | 0.030 | -0.181 | 0.198 |
LVEF | -0.265 | 0.014 | 0.108 | 0.326 |
LVED | 0.279 | 0.014 | -0.295 | 0.01 |
LVES | 0.578 | 0.002 | -0.267 | 0.179 |
LAVI | 0.458 | 0.048 | -0.4 | 0.112 |
RAA | 0.474 | 0.040 | -0.554 | 0.014 |
RVDD | 0.325 | 0.007 | -0.18 | 0.145 |
BUN | 0.371 | < 0.001 | 0.113 | 0.265 |
Creatinine | 0.323 | 0.001 | 0.068 | 0.504 |
Blood sugar | -0.006 | 0.963 | 0.023 | 0.858 |
Discharged eGFR | -0.17 | 0.234 | -0.034 | 0.811 |
Variables | Odds ratio | Confidence interval | P-value |
---|---|---|---|
LVES | 0.876 | 0.490–1.565 | 0.654 |
LVED | 1.087 | 0.552–2.142 | 0.809 |
RVDD | 0.850 | 0.420–1.724 | 0.653 |
BUN | 0.931 | 0.705–1.230 | 0.616 |
RAA | 0.608 | 0.232–1.593 | 0.311 |
variables | Odds ratio | Confidence interval | P-value |
---|---|---|---|
admission uric acid level | 0.615 | 0.408–0.929 | 0.021 |
Age | 0.950 | 0.875–1.031 | 0.223 |
Weight | 0.926 | 0.826–1.039 | 0.191 |
Admission duration | 0.968 | 0.812–1.153 | 0.712 |
Acetazolamide | 0.999 | 0.996–1.001 | 0.324 |
Discharge eGFR | 1.003 | 0.955–1.053 | 0.910 |
IV furosemide | 0.997 | 0.995–0.999 | 0.013 |
Oral furosemide | 1.523 | 2.32 | 0.990 |
Total furosemide | 0.997 | 0.995–1.00 | 0.034 |
BUN | 0.960 | 0.927–0.994 | 0.021 |
Creatinine | 0.492 | 0.274–0.882 | 0.017 |
Blood sugar | 0.995 | 0.989–1.00 | 0.061 |
LVED | 0.913 | 0.807–1.033 | 0.149 |
LVEF | 0.986 | 0.910–1.068 | 0.723 |
LVES | 0.738 | 0.468–1.162 | 0.190 |
RVDD | 1.142 | 0.931–1.401 | 0.204 |
Variables | Odds ratio | Confidence interval | P-value |
---|---|---|---|
Admission uric acid level | 0.771 | 0.490–1.215 | 0.262 |
IV furosemide | 0.702 | 0.001 - | 0.991 |
Oral furosemide | 1.423 | 0.001 - | 0.991 |
BUN | 0.957 | 0.879–1.043 | 0.317 |
Creatinine | 0.979 | 0.319–3.003 | 0.971 |