Introduction
Fluoroquinolones (FQ)
AAD
FQ-increased the risk of AAD
Duration of FQ use and the incidence of AAD
Duration of FQ use | No. of participants | OR (95% CI) | outcome | Reference | Study design |
---|---|---|---|---|---|
≤ 60 | 1477 case patients and 147,700 matched control cases | RR = 2.43, 95% CI 1.83–3.22 | AA or AD | 1 | A nested case–control analysis |
3–14 | 1213 hospitalized AA/AD patients | OR = 2.41; 95% CI 1.13–3.71 | 4 | A case-crossover design | |
≤ 60 | 360,088 | HR = 1.66; 95% CI 1.12–2.46 | AA or AD | 9 | Nationwide historical cohort study |
1,744,360 | Adjusted HR = 2.24, 95% CI 2.02–2.49 | AA | 40 | Population-based longitudinal cohort study | |
RR = 2.14; 95% CI 1.93–2.36 | AA or AD | 33 | A systematic review and meta-analysis | ||
19,207,552 | OR = 2.20; 95% CI 1.92–2.52 | AA or AD | 12 | Cohort and case–control studies | |
> 14 | OR = 2.83, 95% CI 1.06–7.57 | AAD | 42 | A prospective population-based study | |
14–60 | 1213 hospitalized AA/AD patients | OR = 2.83; 95% CI 1.13–3.71 | AA or AD | 4 | A case-crossover design |
61–120 | 360,088 | HR = 0.67; 95% CI 0.40–1.11 | None | 9 | Nationwide historical cohort study |
90 | 27,827,254 | HR = 1.31; 95% CI 1.25–1.37 | AAA | 41 | Cohort study |
27,827,254 | HR = 1.60; 95% CI 1.33–1.91 | Iliac artery aneurysm | 41 | Cohort study | |
27,827,254 | HR = 1.58; 95% CI 1.39–1.79 | Other AAA | 41 | Cohort study |
Types and dosage forms of FQ use and the incidence of AAD
FQ | Outcome | References |
---|---|---|
All FQ | AAD | [44] |
Ciprofloxacin | AAD | [44] |
AA | [45] | |
Levofloxacin | AAD | |
AA | [45] | |
Moxifloxacin | AAD, AA | |
AA | [45] | |
Ofloxacin | None | [44] |
Enoxacin, fleroxacin, gemifloxacin, grepafloxacin, lomefloxacin, norfloxacin, pazufloxacin, pefloxacin, prulifloxacin, rufloxacin, sparfloxacin, temafloxacin, trovafloxacin | None | [46] |
Oral FQ | AAD | |
Oral FQ | AAA, iliac artery aneurysm and other AAA | [41] |
Users of FQ and incidence of AAD
OR (95% CI) | Outcome | Comorbid illnesses | Patient characteristic | References |
---|---|---|---|---|
HR = 2.57; 95% CI 1.36–4.86 | AAD | Pneumonia | [48] | |
OR = 1.01; 95% CI 0.82–1.24 | FQ didn’t increase the risk of AAD | Combined amoxicillin-clavulanate or ampicillin-sulbactam | [52] | |
OR = 0.88; 95% CI 0.70–1.11 | FQ didn’t increase the risk of AAD | Combined with extended-spectrum cephalosporins | [52] | |
Adjusted HR = 2.24; 95% CI 2.02–2.49 | AA | Older adults turning 65 years | [40] | |
HR = 1.66; 95% CI 1.12–2.46 | AAD | Aged 50 years or older | [9] | |
RR = 1.72; 95% CI 1.37–2.16 | AAD | Older than 70 years | [1] | |
HR = 1.18; 95% CI 1.09–1.28 | AA | Aged 35 years or older (35–49 years) | [41] | |
HR = 1.24; 95% CI 1.19–1.28 | AA | Aged 35 years or older (50–64 years) | [41] | |
RR = 1.83; 95% CI 1.27–2.64 | AAD | Female patients | [1] | |
RR = 1.87; 95%CI 1.24–2.51 | AAD | Female patients | [33] | |
OR = 0.92; 95% CI 0.46–1.86 | Intracranial aneurysm or dissection | [52] | ||
Adjusted HR = 1.61; 95% CI 1.50–1.73 | All-cause death | AA or AD | [49] | |
Adjusted HR = 1.80; 95% CI 1.50–2.15 | Aortic death | AA or AD | [49] |