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08.08.2023 | Review

Diabetes and ovarian cancer: risk factors, molecular mechanisms and impact on prognosis

verfasst von: Farzaneh Karimi, Negar Dinarvand, Mohammad Sabaghan, Omid Azadbakht, Shima Ataee, Ebrahim Kharazinejad, Mostafa Moazamfard

Erschienen in: Endocrine | Ausgabe 1/2024

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Abstract

Background and aim

Diabetes mellitus has been linked to a lower rate of cancer survival and an increase in the incidence of most malignancies. Investigations showed that diabetes might affect ovarian cancer (OC) prognosis and survival. Based on the current information, this study intends to review the risk factors, molecular pathways, and impact of diabetes on OC.

Methods

The data was derived from online databases, including Web of Science, PubMed, and Scopus. The inclusion criteria were original studies, which included the risk factors, molecular mechanisms, and impact of diabetes on OC. The effect of different antidiabetic drugs was also discussed in this manuscript. All of the clinical, in vivo, and in vitro studies were included in the present study.

Results

The diagnosis of diabetes mellitus negatively affects the survival and prognosis in OC cases. The epidemiologic data shows that the risk of OC increases in patients with diabetes mellitus compared to the healthy population. Insulin-like growth factors family was raised in diabetic patients, which target several mechanisms, including targeting oxidative stress, angiogenesis, and tumor markers. Antidiabetic drugs such as metformin, sitagliptin, and rosiglitazone have a promising effect on elongation of survival and enhancement of prognosis in OC patients.

Conclusions

Diabetes mellitus is a significant risk factor for OC in women, and it negatively impacts survival and prognosis. Molecular mechanisms such as IGF family, oxidative stress, and inflammatory cytokines have been identified to explain this relationship. Antidiabetic drugs like metformin, sitagliptin, and rosiglitazone have shown promise in improving survival and prognosis of OC patients.

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Titel: Diabetes and ovarian cancer: risk factors, molecular mechanisms and impact on prognosis
verfasst von: Farzaneh Karimi
Negar Dinarvand
Mohammad Sabaghan
Omid Azadbakht
Shima Ataee
Ebrahim Kharazinejad
Mostafa Moazamfard
Publikationsdatum: 08.08.2023
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 1/2024
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-023-03477-6

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Diabetes and ovarian cancer: risk factors, molecular mechanisms and impact on prognosis