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15.05.2024 | Correspondence
Diagnostic Accuracy of Cartridge Based Nucleic Acid Amplification Test (CBNAAT) in Stool Samples in Pediatric Tuberculosis: Correspondence
Erschienen in: Indian Journal of Pediatrics
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To the Editor: We read with interest the article published by Singhal et al. on the accuracy of stool CBNAAT in pediatric tuberculosis published in your journal [1]. We would like to seek certain clarifications from the authors as below.
1.
The study population of 100 cases has 76 children with TB; 32 with pulmonary TB and 44 with extrapulmonary TB. The authors have reported high sensitivity of gastric aspirate (GA) AFB smear, GA CBNAAT and stool CBNAAT in these 76 cases (21/76, 57/76 and 56/76 respectively). From this it appears that many EPTB cases also had positive GA smear/CBNAAT and stool CBNAAT. Hence it would be important to know the types of EPTB in the study population and whether these patients with EPTB had concomitant respiratory symptoms/ abnormal CXR’s. It would also be relevant to know the sensitivity of GA AFB smear/CBNAAT and stool CBNAAT separately for pulmonary and extrapulmonary cases.
2.
The authors also report near comparable sensitivity of stool CBNAAT (73.6%) and GA CBNAAT (75%). This is different from that reported by a systematic review/ meta-analysis where sensitivity of CBNAAT in stool was 50% as against 66% in respiratory specimens [2]. It would be useful to know the authors’ explanation for this higher sensitivity of stool CBNAAT and the stool processing technique used by them for their study.