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20.11.2019 | Original Article

Distribution of infectious endogenous retroviruses in mixed-breed and purebred cats

verfasst von: Minh Ha Ngo, Takehisa Soma, Hwa-Young Youn, Taiji Endo, Isaac Makundi, Junna Kawasaki, Ariko Miyake, Bui Thi To Nga, Huyen Nguyen, MaríaCruz Arnal, Daniel Fernández de Luco, R. M. C. Deshapriya, Shingo Hatoya, Kazuo Nishigaki

Erschienen in: Archives of Virology

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Abstract

Endogenous retroviruses of domestic cats (ERV-DCs) are members of the genus Gammaretrovirus that infect domestic cats (Felis silvestris catus). Uniquely, domestic cats harbor replication-competent proviruses such as ERV-DC10 (ERV-DC18) and ERV-DC14 (xenotropic and nonecotropic viruses, respectively). The purpose of this study was to assess invasion by two distinct infectious ERV-DCs, ERV-DC10 and ERV-DC14, in domestic cats. Of a total sample of 1646 cats, 568 animals (34.5%) were positive for ERV-DC10 (heterozygous: 377; homozygous: 191), 68 animals (4.1%) were positive for ERV-DC14 (heterozygous: 67; homozygous: 1), and 10 animals (0.6%) were positive for both ERV-DC10 and ERV-DC14. ERV-DC10 and ERV-DC14 were detected in domestic cats in Japan as well as in Tanzania, Sri Lanka, Vietnam, South Korea and Spain. Breeding cats, including Singapura, Norwegian Forest and Ragdoll cats, showed high frequencies of ERV-DC10 (60–100%). By contrast, ERV-DC14 was detected at low frequency in breeding cats. Our results suggest that ERV-DC10 is widely distributed while ERV-DC14 is maintained in a minor population of cats. Thus, ERV-DC10 and ERV-DC14 have invaded cat populations independently.
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Metadaten
Titel
Distribution of infectious endogenous retroviruses in mixed-breed and purebred cats
verfasst von
Minh Ha Ngo
Takehisa Soma
Hwa-Young Youn
Taiji Endo
Isaac Makundi
Junna Kawasaki
Ariko Miyake
Bui Thi To Nga
Huyen Nguyen
MaríaCruz Arnal
Daniel Fernández de Luco
R. M. C. Deshapriya
Shingo Hatoya
Kazuo Nishigaki
Publikationsdatum
20.11.2019
Verlag
Springer Vienna
Erschienen in
Archives of Virology
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-019-04454-z

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Bei Menschen mit Typ-2-Diabetes sind die Chancen, einen Myokardinfarkt zu überleben, in den letzten 15 Jahren deutlich gestiegen – nicht jedoch bei Betroffenen mit Typ 1.

15% bedauern gewählte Blasenkrebs-Therapie

29.05.2024 Urothelkarzinom Nachrichten

Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.

Costims – das nächste heiße Ding in der Krebstherapie?

28.05.2024 Onkologische Immuntherapie Nachrichten

„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

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