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European Archives of Psychiatry and Clinical Neuroscience

Erschienen in:

08.07.2023 | Original Paper

EEG microstate co-specificity in schizophrenia and obsessive–compulsive disorder

verfasst von: Bérangère Thirioux, Nicolas Langbour, Prasanth Bokam, Issa Wassouf, Nathalie Guillard-Bouhet, Carole Wangermez, Pierre-Marie Leblanc, Damien Doolub, Ghina Harika-Germaneau, Nematollah Jaafari

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 1/2024

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Abstract

The past 20 years of research on EEG microstates has yielded the hypothesis that the imbalance pattern in the temporal dynamics of microstates C (increased) and D (decreased) is specific to schizophrenia. A similar microstate imbalance has been recently found in obsessive–compulsive disorder (OCD). The aim of the present high-density EEG study was to examine whether this pathological microstate pattern is co-specific to schizophrenia and OCD. We compared microstate temporal dynamics using Bayesian analyses, transition probabilities analyses and the Topographic Electrophysiological State Source-Imaging method for source reconstruction in 24 OCD patients and 28 schizophrenia patients, respectively, free of comorbid psychotic and OCD symptoms, and 27 healthy controls. OCD and schizophrenia patients exhibited the same increased contribution of microstate C, decreased duration and contribution of microstate D and greater D → C transition probabilities, compared with controls. A Bayes factor of 4.424 for the contribution of microstate C, 4.600 and 3.824, respectively, for the duration and contribution of microstate D demonstrated that there was no difference in microstate patterns between the two disorders. Source reconstruction further showed undistinguishable dysregulations between the Salience Network (SN), associated with microstate C, and the Executive Control Network (ECN), associated with microstate D, and between the ECN and cognitive cortico-striato-thalamo-cortical (CSTC) loop in the two disorders. The ECN/CSTC loop dysconnectivity was slightly worsened in schizophrenia. Our findings provide substantial evidence for a common aetiological pathway in schizophrenia and OCD, i.e. microstate co-specificity, and same anomalies in salience and external attention processing, leading to co-expression of symptoms.

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Titel: EEG microstate co-specificity in schizophrenia and obsessive–compulsive disorder
verfasst von: Bérangère Thirioux
Nicolas Langbour
Prasanth Bokam
Issa Wassouf
Nathalie Guillard-Bouhet
Carole Wangermez
Pierre-Marie Leblanc
Damien Doolub
Ghina Harika-Germaneau
Nematollah Jaafari
Publikationsdatum: 08.07.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 1/2024
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-023-01642-6

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EEG microstate co-specificity in schizophrenia and obsessive–compulsive disorder

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