Backgroud
Traditional right ventricular pacing is safe and easy to implant. However, it may deteriorate cardiac function and increase the incidence of atrial fibrillation after long-time application [
1‐
3]. His bundle pacing (HBP) conduction tract is a physiologic pacing site, which truly realizes cardiac physiological synchronization. With the development of tools and improvement of the technique in recent years, the acceptance of HBP has increased. However, HBP is considered to be associated with low sensing values and uncertain long-term results, which are obstacles in its widespread use [
4]. Based on clinical practice, the implantation site of the His lead may have an impact on pacing parameters, for which implanting the leads to the distal site of the His bundle can significantly increase the sensing values. To date, studies on this field are few. In the present study, 2D echocardiography imaging was used to detect the implantation site of leads, and the effect of lead location on pacing parameters was explored. Long-term safety was also evaluated based on follow-up.
Methods
Patient selection
We analyzed all cases of HBP in our hospital from January 2016 to June 2018. All patients had permanent atrial fibrillation with atrioventricular nodal block and clinical symptoms. The selection criteria were as follows: (1) Compliance with selective and nonselective pacing criteria for HBP in 2017 [
5] and (2) standardized follow-up data after operation. The exclusion criteria were as follows: (1) Compliance with left bundle branch block or H-V conduction disturbances, (2) Absence of clear H wave potential and uncertain nonselective pacing during operation, (3) dislocation of the lead within 1 month after operation, and (4) severe multiple organ diseases. The study was approved by the hospital institutional review board, and informed consent was obtained from each patient.
Implantation technique
His bundle leads were implanted through a method similar to that of Sharma [
6]. All patients were implanted with a 4.1-Fr bipolar active fixation lead (Select Secure, model 3830, Medtronic Inc., Minneapolis, MN, USA), assisted by a C315 sheath (C304 sheath if necessary), and some cases were mapped with double leads. H wave to ventricular wave interval (HV interval) was measured using His intraluminal mapping. A Medtronic 2090 programmer was used to measure the parameters. The last unipolar parameters were recorded before the permanent pacemaker was connected. The pulse width was set to 0.5 ms, and 5.6 mV was recorded if the sensing values were over 5.6 mV. Overdrive pacing at 110 times/ min was used to rule out patients with H-V conduction disturbances.
Echocardiography mapping
Echocardiography was done both before and within one-week after the operation in the ward using a GE log9 ultrasonic device. First, we completed the routine measurement of echocardiography parameters, such as left ventricular ID, left atrium ID, EF, tricuspid regurgitation and so on. Then we managed to find the tip of His lead during the first week echo-reexamine. We detected the fixed position of the His lead tip by combining the apex four-chamber mapping with the parasternal four-chamber mapping. Tricuspid annulus was defined as following the ESC/EACTS guidelines for the management of valvular heart disease [
7]. Attachment point of tricuspid septal valve was used as the measurement mark of the tricuspid annulus. The distance from the tip of the lead to the mark was measured, and the average value of three measurements was recorded. The tip at the atrial side of the annulus was marked negative and the ventricular side positive. We utilized following methods to decrease error as much as possible: eco information was done by the same clinical specialist using the same type of device; data was read at diastolic phase; three data were collected, and the average value was applied for every patient.
Follow-up
Patients were followed up in the clinic at 1, 3, 6, and 12 months after operation and half yearly thereafter. During the follow-up, electrocardiogram (ECG), echocardiography, brain natriuretic peptide test, and other examinations were completed as required, and New York Heart Association failure classification grade was assessed. The capture thresholds, sensing values, impedance, and pacing ratio were measured using a Medtronic 2090 programmer. The pacemaker was programmed to AAI mode to obtain the His lead parameters if possible, and the sensing value was measured using a unipolar. Far-field atrial over-sensing was excluded via different sensing sensitivities to obtain the real sensing values. If the capture threshold was below 0.5 V/0.5 ms, 0.5 mV was recorded, and sensing values above 5.6 mV was recorded as 5.6 mV.
Statistical analysis
Statistical analysis was carried out using SPSS 20.0 software. Continuous data are presented as mean ± standard deviation, while counting data are presented as %. Significant differences between groups were detected by either t-test or chi square test. The statistical significance was defined as a p-value < 0.05.
Discussion
His bundle connects the atrioventricular node with the left and right bundle branches. It originates from the atrioventricular node and passes through the membranous interventricular septum. The average length of the bundle is 20 mm. Any part of the bundle can be located for pacing. However, reports on the location of HBP leads and the effect of the location site on pacing parameters are few. Correa de Sa et al. [
8] reported a case of an 81-year-old woman who had been implanted with HBP leads 2 years before death. Anatomical observations revealed that the tip of the lead was located at the atrial side of the tricuspid annulus. Vijayaraman et al. [
9] assessed a 42-year-old man with His lead via 2D echocardiography and CT imaging. The tip of the His lead was implanted at the atrial side of the tricuspid annulus. Those authors suggested that atrial side HBP can reduce the impact on the tricuspid valve, which is considered an advantage of HBP. Alexander et al. [
10] studied five canine hearts in vitro to determine whether the location of the lead affects the pacing parameters. They analyzed the relationship between lead location sites and pacing parameters and ECG morphology at four different sites of the His bundle from the proximal to the distal locations. The results showed that the difference between the proximal (area 2) and distal (area 4) locations on capture threshold was not significant, but the proportion of selective pacing in the former was higher than that in the latter. Of note, none of the above-mentioned studies described influence of the location of the His lead on sensing values. The finding of our current work, that is, that the implantation site of HBP leads has a significant effect on the sensing values may contribute to limited literature available on the effects of HBP implantation site.
In the present study, we selected carefully 29 cases according to 2017 standard definitions of HBP [
5]. The location sites of His leads were determined by 2D echocardiography imaging. According to the relationship between the tips of the His leads and the tricuspid annulus, the patients were divided into groups A (whose tips were on the atrial side) and B (whose tips were on the ventricular side). The difference in capture threshold between the two groups at the same time was not significant, and the proportion of selective pacing was higher in group A than in group B, which is consistent with the aforementioned canine study in vitro. Meanwhile, the sensing values were significantly higher in group B than those in group A. With the leads crossing to the ventricular side, especially in patients with crossing annulus over 5 mm, the sensing values were over 4 mV, suggesting that distal HBP can solve the problem of low sensing values. The compared HV interval between the two groups suggests that the HV interval was shortened after the leads crossed the annulus. The average HV interval in group B was 36 ms, which was significantly shorter than the 49 ms interval in group A. In the more distal group (D), the HV interval was further shortened to 35 ms, suggesting that the conduction of the His bundle from the proximal to the distal location was approximately 15 ms.
In practice, it is technically difficult to determine whether the His lead has crossed the annulus during surgery by using DSA images. Our experience from current study suggested that it can be helpful to determine whether distal HBP is achieved by measuring sensing values and HV interval during surgery. We suggest the use of sensing values over 4.0 mV combined with HV interval shorter than 40 ms as a reference index for distal HBP.
The capture threshold of HBP pacing is considered higher than that of conventional ventricular pacing. Vijayaraman et al. [
4] reported 75 cases with an average implantation capture threshold of 1.35 ± 0.9 V/0.5 ms. In current study, the average intra-operative capture threshold was 1.16 ± 0.38 V /0.5 ms, which is slightly higher than the usual ventricular threshold. Short-term follow-up results showed that the capture threshold improved significantly, and the average capture threshold decreased to 0.76 ± 0.35 V/0.5 ms at 1 month. During the follow-up period, approximately 90% of the cases remained stable, and approximately 80% of them had a chronic threshold of less than 1.0 V. Combined with case 29 analysis, the capture threshold of HBP may be similar to that of the ventricular pacing but with prolonged waiting time. Since the increasement of the His lead capture threshold is closely related to intra-operative lead fixation, we suggest referring to LAO 40°–45° fluoroscopy image to ensure that the His lead is vertically fixed.
We also summarized the following practice notes from our experience: the pacemaker should be programmed to AAI mode if possible to measure His lead parameters and to avoid potential interference. When the lead tip is on the atrial side, theoretically the lead can sense the potential of the atrium and the ventricular, and the atrial potential is always before that of the ventricular. When the pacemaker senses the atrial one, it would no longer sense the ventricular one, which may lead to a false low sensing value. When sensing is measured, the sense sensitivity should be adjusted to avoid excessive sensitivity setting, leading to far-field atrial sensing, which is always mistaken for a low His sensing value. We noticed this phenomenon happened in four cases in group A, which was related to the position of the His lead and potential size of atrium. It is believed that atrial cross sensing might lead to cardiac arrest if the patient is dependent on pacing. Although up to now no systemic study has been reported on this topic, we suggest plant the lead to a distal site to avoid this problem.
An important concern on HBP is the long-term safety especially for sHBP in the atrium. We ruled out patients with LBBB or wide QRS morphology and used overdriving pacing during operation to reduce this problem. We also planted a second ventricular lead for safety. Non-selective pacing which means capture both His-purkinje system and surrounding RV myocardium might be safer. In our study, the sensing value was better in non-selective group; the capture threshold was similar between the two groups. Actually, for all the cases worked under non-selective pacing mode at working output potential over 2.5 v/0.5 ms, no case was recorded with new conduction disturbances during the follow-up period.
In summary, we have two major findings in this study. First, the sensing values of His lead-crossed tricuspid annulus were improved significantly, and the farther distal the lead is, the better the sensing value. Second, the correlation between the location of the leads and capture thresholds was not significant. The capture thresholds decreased significantly at 1-month follow-up after operation and are kept steady in the late period. Nevertheless, this work has several limitations. This is a small-scale single-center observational study with limited follow-up time. Distal HBP requires more surgical techniques than the proximal one, which restricts its widespread application. Moreover, it requires more implantation tools to simplify its operation. The long-term safety and efficacy of distal HBP still require a large sample of multicenter prospective clinical trials.
In conclusion, HBP is a promising mode of physiological pacing for future applications in patients. Further studies on the effects of implantation location on HBP leads and improvement of this technique through further clinical trials may lead to its more widespread adaptation.
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.