Erschienen in:
02.12.2022 | Brief Report
Effect of MP-AzeFlu in IL-1 beta-induced IL-6 and proinflammatory cytokines
verfasst von:
Sònia Vicens-Artés, Jordi Roca-Ferrer, Valeria Tubita, Mireya Fuentes, Isam Alobid, Antonio Valero, Ferdinand Kopietz, DucTung Nguyen, Joaquim Mullol
Erschienen in:
Immunologic Research
|
Ausgabe 3/2023
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Excerpt
Allergic rhinitis (AR) is a T-helper 2 (Th-2) immunoglobulin E (IgE)-mediated disease characterized by elevated levels of proinflammatory mediators, eosinophil infiltration of the nasal mucosa, and mucus hyperproduction [
1]. The late-phase molecular response is most likely mediated via the production of a host of cytokines, including interleukin 6 (IL-6), interleukin 8 (IL-8), and granulocyte–macrophage colony-stimulating factor (GM-CSF) by mast cells, Th-2 lymphocytes, or epithelial cells [
1]. Chronic rhinosinusitis (CRS) may present with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP) and is a chronic inflammatory disease of the nasal passages characterized by persistent inflammation and remodeling of the sinonasal mucosa. It is frequently associated with asthma and nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD). …
