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02.11.2022 | Sleep Breathing Physiology and Disorders • Review

Emerging role of metabolomics for biomarker discovery in obstructive sleep apnea

verfasst von: Mohit, Manendra Singh Tomar, Deepak Sharma, Shiv Nandan, Ankit Pateriya, Ashutosh Shrivastava, Pooran Chand

Erschienen in: Sleep and Breathing | Ausgabe 4/2023

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Abstract

Obstructive sleep apnea (OSA) is characterized by the complete or partial blockage of the upper airway passage during sleep which causes repetitive breaks in sleep and may result in excessive daytime sleepiness. OSA has been linked to various metabolic disorders and chronic health conditions, such as obesity, diabetes, hypertension, and depression. Profiling of alterations in metabolites and their regulation in OSA has been hypothesized to be an effective approach for early diagnosis and prognosis of OSA. Several studies have characterized metabolic fingerprints associated with sleep disorders. There is a lack of understanding of metabolite contents and their alterations in OSA that may help to identify specific biomarkers. The information provided in this review will help update new methodologies and interventions of high throughput advanced molecular/metabolomics tools which may clarify the metabolic aspects and mechanisms for improved management and treatment of OSA.

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Titel: Emerging role of metabolomics for biomarker discovery in obstructive sleep apnea
verfasst von: Mohit
Manendra Singh Tomar
Deepak Sharma
Shiv Nandan
Ankit Pateriya
Ashutosh Shrivastava
Pooran Chand
Publikationsdatum: 02.11.2022
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 4/2023
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-022-02730-y

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Emerging role of metabolomics for biomarker discovery in obstructive sleep apnea

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