Skip to main content
Erschienen in: Current Allergy and Asthma Reports 8/2023

25.05.2023

Environmental Exposure to Foods as a Risk Factor for Food Allergy

verfasst von: Andrew V. Turner, Johanna M. Smeekens

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 8/2023

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Many factors have been reported to contribute to the development of food allergy. Here, we summarize the role of environmental exposure to foods as a major risk factor for developing food allergy.

Recent Findings

Peanut proteins are detectable and biologically active in household environments, where infants spend a majority of their time, providing an environmental source of allergen exposure. Recent evidence from clinical studies and mouse models suggests both the airway and skin are routes of exposure that lead to peanut sensitization.

Summary

Environmental exposure to peanut has been clearly associated with the development of peanut allergy, although other factors such as genetic predisposition, microbial exposures, and timing of oral feeding of allergens also likely contribute. Future studies should more comprehensively assess the contributions of each of these factors for a variety of food allergens to provide more clear targets for prevention of food allergy.
Literatur
1.
Zurück zum Zitat Gupta RS, Warren CM, Smith BM, Jiang J, Blumenstock JA, Davis MM, et al. Prevalence and severity of food allergies among US adults. JAMA Netw Open. 2019;2:e185630.PubMedPubMedCentral Gupta RS, Warren CM, Smith BM, Jiang J, Blumenstock JA, Davis MM, et al. Prevalence and severity of food allergies among US adults. JAMA Netw Open. 2019;2:e185630.PubMedPubMedCentral
2.
Zurück zum Zitat Branum AM, Lukacs SL. Food allergy among children in the United States. Pediatrics. 2009;124:1549–55.PubMed Branum AM, Lukacs SL. Food allergy among children in the United States. Pediatrics. 2009;124:1549–55.PubMed
3.
4.
Zurück zum Zitat Investigators PGoC, Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, et al. AR101 oral immunotherapy for peanut allergy. N Engl J Med. 2018;379:1991–2001. Investigators PGoC, Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, et al. AR101 oral immunotherapy for peanut allergy. N Engl J Med. 2018;379:1991–2001.
5.
Zurück zum Zitat Avery NJ, King RM, Knight S, Hourihane JO. Assessment of quality of life in children with peanut allergy. Pediatr Allergy Immunol. 2003;14:378–82.PubMed Avery NJ, King RM, Knight S, Hourihane JO. Assessment of quality of life in children with peanut allergy. Pediatr Allergy Immunol. 2003;14:378–82.PubMed
7.
Zurück zum Zitat Smeekens JM, Kulis MD. Evolution of immune responses in food immunotherapy. Immunol Allergy Clin North Am. 2020;40:87–95.PubMed Smeekens JM, Kulis MD. Evolution of immune responses in food immunotherapy. Immunol Allergy Clin North Am. 2020;40:87–95.PubMed
8.
Zurück zum Zitat Sicherer SH, Burks AW, Sampson HA. Clinical features of acute allergic reactions to peanut and tree nuts in children. Pediatrics. 1998;102:e6.PubMed Sicherer SH, Burks AW, Sampson HA. Clinical features of acute allergic reactions to peanut and tree nuts in children. Pediatrics. 1998;102:e6.PubMed
9.
Zurück zum Zitat Lack G. Update on risk factors for food allergy. J Allergy Clin Immunol. 2012;129:1187–97.PubMed Lack G. Update on risk factors for food allergy. J Allergy Clin Immunol. 2012;129:1187–97.PubMed
10.
Zurück zum Zitat Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015;372:803–13.PubMedPubMedCentral Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015;372:803–13.PubMedPubMedCentral
11.
Zurück zum Zitat Du Toit G, Sayre PH, Roberts G, Sever ML, Lawson K, Bahnson HT, et al. Effect of avoidance on peanut allergy after early peanut consumption. N Engl J Med. 2016;374:1435–43.PubMed Du Toit G, Sayre PH, Roberts G, Sever ML, Lawson K, Bahnson HT, et al. Effect of avoidance on peanut allergy after early peanut consumption. N Engl J Med. 2016;374:1435–43.PubMed
12.
Zurück zum Zitat Perkin MR, Logan K, Tseng A, Raji B, Ayis S, Peacock J, et al. Randomized trial of introduction of allergenic foods in breast-fed infants. N Engl J Med. 2016;374:1733–43.PubMed Perkin MR, Logan K, Tseng A, Raji B, Ayis S, Peacock J, et al. Randomized trial of introduction of allergenic foods in breast-fed infants. N Engl J Med. 2016;374:1733–43.PubMed
13.
Zurück zum Zitat Sicherer SH, Sampson HA. Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol. 2018;141:41–58.PubMed Sicherer SH, Sampson HA. Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol. 2018;141:41–58.PubMed
14.
Zurück zum Zitat Peters RL, Mavoa S, Koplin JJ. An overview of environmental risk factors for food allergy. Int J Environ Res Public Health. 2022;19. Peters RL, Mavoa S, Koplin JJ. An overview of environmental risk factors for food allergy. Int J Environ Res Public Health. 2022;19.
15.
Zurück zum Zitat Moran TP. Impact of the exposome on food allergy development. Curr Opin Allergy Clin Immunol. 2023;23:164–71.PubMed Moran TP. Impact of the exposome on food allergy development. Curr Opin Allergy Clin Immunol. 2023;23:164–71.PubMed
16.
Zurück zum Zitat Yu JE, Mallapaty A, Miller RL. It’s not just the food you eat: environmental factors in the development of food allergies. Environ Res. 2018;165:118–24.PubMed Yu JE, Mallapaty A, Miller RL. It’s not just the food you eat: environmental factors in the development of food allergies. Environ Res. 2018;165:118–24.PubMed
17.
Zurück zum Zitat Maciag MC, Sheehan WJ, Bartnikas LM, Lai PS, Petty CR, Filep S, et al. Detection of food allergens in school and home environments of elementary students. J Allergy Clin Immunol Pract. 2021;9:3735–43.PubMedPubMedCentral Maciag MC, Sheehan WJ, Bartnikas LM, Lai PS, Petty CR, Filep S, et al. Detection of food allergens in school and home environments of elementary students. J Allergy Clin Immunol Pract. 2021;9:3735–43.PubMedPubMedCentral
18.
Zurück zum Zitat Bertelsen RJ, Faeste CK, Granum B, Egaas E, London SJ, Carlsen KH, et al. Food allergens in mattress dust in Norwegian homes - a potentially important source of allergen exposure. Clin Exp Allergy. 2014;44:142–9.PubMedPubMedCentral Bertelsen RJ, Faeste CK, Granum B, Egaas E, London SJ, Carlsen KH, et al. Food allergens in mattress dust in Norwegian homes - a potentially important source of allergen exposure. Clin Exp Allergy. 2014;44:142–9.PubMedPubMedCentral
19.
Zurück zum Zitat Brough HA, Makinson K, Penagos M, Maleki SJ, Cheng H, Douiri A, et al. Distribution of peanut protein in the home environment. J Allergy Clin Immunol. 2013;132:623–9.PubMed Brough HA, Makinson K, Penagos M, Maleki SJ, Cheng H, Douiri A, et al. Distribution of peanut protein in the home environment. J Allergy Clin Immunol. 2013;132:623–9.PubMed
20.
Zurück zum Zitat Sheehan WJ, Brough HA, Makinson K, Petty CR, Lack G, Phipatanakul W. Distribution of peanut protein in school and home environments of inner-city children. J Allergy Clin Immunol. 2017;140:1724–6.PubMedPubMedCentral Sheehan WJ, Brough HA, Makinson K, Petty CR, Lack G, Phipatanakul W. Distribution of peanut protein in school and home environments of inner-city children. J Allergy Clin Immunol. 2017;140:1724–6.PubMedPubMedCentral
21.
Zurück zum Zitat Brough HA, Mills ENC, Richards K, Lack G, Johnson PE. Mass spectrometry confirmation that clinically important peanut protein allergens are present in household dust. Allergy. 2020;75:709–12.PubMed Brough HA, Mills ENC, Richards K, Lack G, Johnson PE. Mass spectrometry confirmation that clinically important peanut protein allergens are present in household dust. Allergy. 2020;75:709–12.PubMed
22.
Zurück zum Zitat Brough HA, Santos AF, Makinson K, Penagos M, Stephens AC, Douiri A, et al. Peanut protein in household dust is related to household peanut consumption and is biologically active. J Allergy Clin Immunol. 2013;132:630–8.PubMed Brough HA, Santos AF, Makinson K, Penagos M, Stephens AC, Douiri A, et al. Peanut protein in household dust is related to household peanut consumption and is biologically active. J Allergy Clin Immunol. 2013;132:630–8.PubMed
23.
Zurück zum Zitat Brough HA, Liu AH, Sicherer S, Makinson K, Douiri A, Brown SJ, et al. Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy. J Allergy Clin Immunol. 2015;135:164–70.PubMedPubMedCentral Brough HA, Liu AH, Sicherer S, Makinson K, Douiri A, Brown SJ, et al. Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy. J Allergy Clin Immunol. 2015;135:164–70.PubMedPubMedCentral
24.
Zurück zum Zitat Trendelenburg V, Tschirner S, Niggemann B, Beyer K. Hen’s egg allergen in house and bed dust is significantly increased after hen’s egg consumption-a pilot study. Allergy. 2018;73:261–4.PubMed Trendelenburg V, Tschirner S, Niggemann B, Beyer K. Hen’s egg allergen in house and bed dust is significantly increased after hen’s egg consumption-a pilot study. Allergy. 2018;73:261–4.PubMed
25.
Zurück zum Zitat Witteman AM, van Leeuwen J, van der Zee J, Aalberse RC. Food allergens in house dust. Int Arch Allergy Immunol. 1995;107:566–8.PubMed Witteman AM, van Leeuwen J, van der Zee J, Aalberse RC. Food allergens in house dust. Int Arch Allergy Immunol. 1995;107:566–8.PubMed
26.
Zurück zum Zitat Ng N, Lam D, Paulus P, Batzer G, Horner AA. House dust extracts have both TH2 adjuvant and tolerogenic activities. J Allergy Clin Immunol. 2006;117:1074–81.PubMed Ng N, Lam D, Paulus P, Batzer G, Horner AA. House dust extracts have both TH2 adjuvant and tolerogenic activities. J Allergy Clin Immunol. 2006;117:1074–81.PubMed
27.
Zurück zum Zitat Moran TP, Nakano K, Whitehead GS, Thomas SY, Cook DN, Nakano H. Inhaled house dust programs pulmonary dendritic cells to promote type 2 T-cell responses by an indirect mechanism. Am J Physiol Lung Cell Mol Physiol. 2015;309:L1208–18.PubMedPubMedCentral Moran TP, Nakano K, Whitehead GS, Thomas SY, Cook DN, Nakano H. Inhaled house dust programs pulmonary dendritic cells to promote type 2 T-cell responses by an indirect mechanism. Am J Physiol Lung Cell Mol Physiol. 2015;309:L1208–18.PubMedPubMedCentral
28.
Zurück zum Zitat Gough L, Sewell HF, Shakib F. The proteolytic activity of the major dust mite allergen Der p 1 enhances the IgE antibody response to a bystander antigen. Clin Exp Allergy. 2001;31:1594–8.PubMed Gough L, Sewell HF, Shakib F. The proteolytic activity of the major dust mite allergen Der p 1 enhances the IgE antibody response to a bystander antigen. Clin Exp Allergy. 2001;31:1594–8.PubMed
29.
Zurück zum Zitat Boasen J, Chisholm D, Lebet L, Akira S, Horner AA. House dust extracts elicit Toll-like receptor-dependent dendritic cell responses. J Allergy Clin Immunol. 2005;116:185–91.PubMed Boasen J, Chisholm D, Lebet L, Akira S, Horner AA. House dust extracts elicit Toll-like receptor-dependent dendritic cell responses. J Allergy Clin Immunol. 2005;116:185–91.PubMed
30.
Zurück zum Zitat Schuijs MJ, Willart MA, Vergote K, Gras D, Deswarte K, Ege MJ, et al. Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells. Science. 2015;349:1106–10.PubMed Schuijs MJ, Willart MA, Vergote K, Gras D, Deswarte K, Ege MJ, et al. Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells. Science. 2015;349:1106–10.PubMed
31.
Zurück zum Zitat Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, et al. Innate immunity and asthma risk in Amish and Hutterite farm children. N Engl J Med. 2016;375:411–21.PubMedPubMedCentral Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, et al. Innate immunity and asthma risk in Amish and Hutterite farm children. N Engl J Med. 2016;375:411–21.PubMedPubMedCentral
32.
Zurück zum Zitat Hill DJ, Sporik R, Thorburn J, Hosking CS. The association of atopic dermatitis in infancy with immunoglobulin E food sensitization. J Pediatr. 2000;137:475–9.PubMed Hill DJ, Sporik R, Thorburn J, Hosking CS. The association of atopic dermatitis in infancy with immunoglobulin E food sensitization. J Pediatr. 2000;137:475–9.PubMed
33.
Zurück zum Zitat Elias PM, Steinhoff M. “Outside-to-inside” (and now back to “outside”) pathogenic mechanisms in atopic dermatitis. J Invest Dermatol. 2008;128:1067–70.PubMedPubMedCentral Elias PM, Steinhoff M. “Outside-to-inside” (and now back to “outside”) pathogenic mechanisms in atopic dermatitis. J Invest Dermatol. 2008;128:1067–70.PubMedPubMedCentral
34.
Zurück zum Zitat Brough HA, Kull I, Richards K, Hallner E, Söderhäll C, Douiri A, et al. Environmental peanut exposure increases the risk of peanut sensitization in high-risk children. Clin Exp Allergy. 2018;48:586–93.PubMed Brough HA, Kull I, Richards K, Hallner E, Söderhäll C, Douiri A, et al. Environmental peanut exposure increases the risk of peanut sensitization in high-risk children. Clin Exp Allergy. 2018;48:586–93.PubMed
35.
Zurück zum Zitat Brough HA, Simpson A, Makinson K, Hankinson J, Brown S, Douiri A, et al. Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations. J Allergy Clin Immunol. 2014;134:867-75.e1.PubMedPubMedCentral Brough HA, Simpson A, Makinson K, Hankinson J, Brown S, Douiri A, et al. Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations. J Allergy Clin Immunol. 2014;134:867-75.e1.PubMedPubMedCentral
36.
Zurück zum Zitat • Tsilochristou O, du Toit G, Sayre PH, Roberts G, Lawson K, Sever ML, et al. Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity. J Allergy Clin Immunol. 2019;144:494–503. Independent of eczema severity, Staphylococcus aureus colonization was associated with food allergy in LEAP participants.PubMed • Tsilochristou O, du Toit G, Sayre PH, Roberts G, Lawson K, Sever ML, et al. Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity. J Allergy Clin Immunol. 2019;144:494–503. Independent of eczema severity, Staphylococcus aureus colonization was associated with food allergy in LEAP participants.PubMed
37.
Zurück zum Zitat Chan SM, Turcanu V, Stephens AC, Fox AT, Grieve AP, Lack G. Cutaneous lymphocyte antigen and α4β7 T-lymphocyte responses are associated with peanut allergy and tolerance in children. Allergy. 2012;67:336–42.PubMed Chan SM, Turcanu V, Stephens AC, Fox AT, Grieve AP, Lack G. Cutaneous lymphocyte antigen and α4β7 T-lymphocyte responses are associated with peanut allergy and tolerance in children. Allergy. 2012;67:336–42.PubMed
38.
Zurück zum Zitat DeLong JH, Simpson KH, Wambre E, James EA, Robinson D, Kwok WW. Ara h 1-reactive T cells in individuals with peanut allergy. J Allergy Clin Immunol. 2011;127:1211-8.e3.PubMedPubMedCentral DeLong JH, Simpson KH, Wambre E, James EA, Robinson D, Kwok WW. Ara h 1-reactive T cells in individuals with peanut allergy. J Allergy Clin Immunol. 2011;127:1211-8.e3.PubMedPubMedCentral
39.
Zurück zum Zitat Blom LH, Juel-Berg N, Larsen LF, Hansen KS, Poulsen LK. Circulating allergen-specific T. J Allergy Clin Immunol. 2018;141:1498-501.e5.PubMed Blom LH, Juel-Berg N, Larsen LF, Hansen KS, Poulsen LK. Circulating allergen-specific T. J Allergy Clin Immunol. 2018;141:1498-501.e5.PubMed
40.
Zurück zum Zitat Ganeshan K, Neilsen CV, Hadsaitong A, Schleimer RP, Luo X, Bryce PJ. Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model. J Allergy Clin Immunol. 2009;123:231-8.e4.PubMed Ganeshan K, Neilsen CV, Hadsaitong A, Schleimer RP, Luo X, Bryce PJ. Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model. J Allergy Clin Immunol. 2009;123:231-8.e4.PubMed
41.
Zurück zum Zitat Li XM, Serebrisky D, Lee SY, Huang CK, Bardina L, Schofield BH, et al. A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses. J Allergy Clin Immunol. 2000;106:150–8.PubMed Li XM, Serebrisky D, Lee SY, Huang CK, Bardina L, Schofield BH, et al. A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses. J Allergy Clin Immunol. 2000;106:150–8.PubMed
42.
Zurück zum Zitat Walker MT, Green JE, Ferrie RP, Queener AM, Kaplan MH, Cook-Mills JM. Mechanism for initiation of food allergy: dependence on skin barrier mutations and environmental allergen costimulation. J Allergy Clin Immunol. 2018;141:1711-25.e9.PubMedPubMedCentral Walker MT, Green JE, Ferrie RP, Queener AM, Kaplan MH, Cook-Mills JM. Mechanism for initiation of food allergy: dependence on skin barrier mutations and environmental allergen costimulation. J Allergy Clin Immunol. 2018;141:1711-25.e9.PubMedPubMedCentral
43.
Zurück zum Zitat Strid J, Hourihane J, Kimber I, Callard R, Strobel S. Epicutaneous exposure to peanut protein prevents oral tolerance and enhances allergic sensitization. Clin Exp Allergy. 2005;35:757–66.PubMed Strid J, Hourihane J, Kimber I, Callard R, Strobel S. Epicutaneous exposure to peanut protein prevents oral tolerance and enhances allergic sensitization. Clin Exp Allergy. 2005;35:757–66.PubMed
44.
Zurück zum Zitat • Buelow LM, Hoji A, Tat K, Schroeder-Carter LM, Carroll DJ, Cook-Mills JM. Mechanisms for Alternaria alternata function in the skin during induction of peanut allergy in neonatal mice with skin barrier mutations. Front Allergy. 2021;2:677019. Flaky tail mice exposed to peanut with Alternaria alternata, a fungal allergen commonly found in household dust, led to peanut-specific IgE and anaphylaxis to peanut through pathways involving IL-33, oncostatin M, and amphiregulin induced in the skin.PubMedPubMedCentral • Buelow LM, Hoji A, Tat K, Schroeder-Carter LM, Carroll DJ, Cook-Mills JM. Mechanisms for Alternaria alternata function in the skin during induction of peanut allergy in neonatal mice with skin barrier mutations. Front Allergy. 2021;2:677019. Flaky tail mice exposed to peanut with Alternaria alternata, a fungal allergen commonly found in household dust, led to peanut-specific IgE and anaphylaxis to peanut through pathways involving IL-33, oncostatin M, and amphiregulin induced in the skin.PubMedPubMedCentral
45.
Zurück zum Zitat Tordesillas L, Goswami R, Benede S, Grishina G, Dunkin D, Jarvinen KM, et al. Skin exposure promotes a Th2-dependent sensitization to peanut allergens. J Clin Invest. 2014;124:4965–75.PubMedPubMedCentral Tordesillas L, Goswami R, Benede S, Grishina G, Dunkin D, Jarvinen KM, et al. Skin exposure promotes a Th2-dependent sensitization to peanut allergens. J Clin Invest. 2014;124:4965–75.PubMedPubMedCentral
46.
Zurück zum Zitat •• Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, et al. Mechanical skin injury promotes food anaphylaxis by driving intestinal mast cell expansion. Immunity. 2019;50:1262-75.e4. Tape stripping mice led to mast cell expansion in the gut by skin-derived IL-33, gut-derived IL-25, ILC2 activation, and IL-4 production, demonstrating a direct link between skin barrier disruption and intestinal response.PubMedPubMedCentral •• Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, et al. Mechanical skin injury promotes food anaphylaxis by driving intestinal mast cell expansion. Immunity. 2019;50:1262-75.e4. Tape stripping mice led to mast cell expansion in the gut by skin-derived IL-33, gut-derived IL-25, ILC2 activation, and IL-4 production, demonstrating a direct link between skin barrier disruption and intestinal response.PubMedPubMedCentral
47.
Zurück zum Zitat Bartnikas LM, Gurish MF, Burton OT, Leisten S, Janssen E, Oettgen HC, et al. Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. J Allergy Clin Immunol. 2013;131:451–60.e1–6. Bartnikas LM, Gurish MF, Burton OT, Leisten S, Janssen E, Oettgen HC, et al. Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. J Allergy Clin Immunol. 2013;131:451–60.e1–6.
48.
Zurück zum Zitat Wavrin S, Bernard H, Wal JM, Adel-Patient K. Cutaneous or respiratory exposures to peanut allergens in mice and their impacts on subsequent oral exposure. Int Arch Allergy Immunol. 2014;164:189–99.PubMed Wavrin S, Bernard H, Wal JM, Adel-Patient K. Cutaneous or respiratory exposures to peanut allergens in mice and their impacts on subsequent oral exposure. Int Arch Allergy Immunol. 2014;164:189–99.PubMed
49.
Zurück zum Zitat Dunkin D, Berin MC, Mayer L. Allergic sensitization can be induced via multiple physiologic routes in an adjuvant-dependent manner. J Allergy Clin Immunol. 2011;128:1251-8.e2.PubMedPubMedCentral Dunkin D, Berin MC, Mayer L. Allergic sensitization can be induced via multiple physiologic routes in an adjuvant-dependent manner. J Allergy Clin Immunol. 2011;128:1251-8.e2.PubMedPubMedCentral
50.
Zurück zum Zitat Gao H, Jorgensen R, Raghunath R, Ng PKW, Gangur V. An adjuvant-free mouse model using skin sensitization without tape-stripping followed by oral elicitation of anaphylaxis: a novel pre-clinical tool for testing intrinsic wheat allergenicity. Front Allergy. 2022;3:926576.PubMedPubMedCentral Gao H, Jorgensen R, Raghunath R, Ng PKW, Gangur V. An adjuvant-free mouse model using skin sensitization without tape-stripping followed by oral elicitation of anaphylaxis: a novel pre-clinical tool for testing intrinsic wheat allergenicity. Front Allergy. 2022;3:926576.PubMedPubMedCentral
51.
Zurück zum Zitat Birmingham NP, Parvataneni S, Hassan HM, Harkema J, Samineni S, Navuluri L, et al. An adjuvant-free mouse model of tree nut allergy using hazelnut as a model tree nut. Int Arch Allergy Immunol. 2007;144:203–10.PubMed Birmingham NP, Parvataneni S, Hassan HM, Harkema J, Samineni S, Navuluri L, et al. An adjuvant-free mouse model of tree nut allergy using hazelnut as a model tree nut. Int Arch Allergy Immunol. 2007;144:203–10.PubMed
52.
Zurück zum Zitat Parvataneni S, Gonipeta B, Tempelman RJ, Gangur V. Development of an adjuvant-free cashew nut allergy mouse model. Int Arch Allergy Immunol. 2009;149:299–304.PubMed Parvataneni S, Gonipeta B, Tempelman RJ, Gangur V. Development of an adjuvant-free cashew nut allergy mouse model. Int Arch Allergy Immunol. 2009;149:299–304.PubMed
53.
Zurück zum Zitat Parvataneni S, Gonipeta B, Acharya HG, Gangur V. An adjuvant-free mouse model of transdermal sensitization and oral elicitation of anaphylaxis to shellfish. Int Arch Allergy Immunol. 2015;168:269–76.PubMed Parvataneni S, Gonipeta B, Acharya HG, Gangur V. An adjuvant-free mouse model of transdermal sensitization and oral elicitation of anaphylaxis to shellfish. Int Arch Allergy Immunol. 2015;168:269–76.PubMed
54.
Zurück zum Zitat Gonipeta B, Parvataneni S, Tempelman RJ, Gangur V. An adjuvant-free mouse model to evaluate the allergenicity of milk whey protein. J Dairy Sci. 2009;92:4738–44.PubMed Gonipeta B, Parvataneni S, Tempelman RJ, Gangur V. An adjuvant-free mouse model to evaluate the allergenicity of milk whey protein. J Dairy Sci. 2009;92:4738–44.PubMed
55.
Zurück zum Zitat Navuluri L, Parvataneni S, Hassan H, Birmingham NP, Kelly C, Gangur V. Allergic and anaphylactic response to sesame seeds in mice: identification of Ses i 3 and basic subunit of 11s globulins as allergens. Int Arch Allergy Immunol. 2006;140:270–6.PubMed Navuluri L, Parvataneni S, Hassan H, Birmingham NP, Kelly C, Gangur V. Allergic and anaphylactic response to sesame seeds in mice: identification of Ses i 3 and basic subunit of 11s globulins as allergens. Int Arch Allergy Immunol. 2006;140:270–6.PubMed
56.
Zurück zum Zitat •• Kulis MD, Smeekens JM, Immormino RM, Moran TP. The airway as a route of sensitization to peanut: an update to the dual allergen exposure hypothesis. J Allergy Clin Immunol. 2021;148:689–93. An updated dual allergen exposure hypothesis including non-oral sensitization through both the airway and skin, citing human and mouse data.PubMedPubMedCentral •• Kulis MD, Smeekens JM, Immormino RM, Moran TP. The airway as a route of sensitization to peanut: an update to the dual allergen exposure hypothesis. J Allergy Clin Immunol. 2021;148:689–93. An updated dual allergen exposure hypothesis including non-oral sensitization through both the airway and skin, citing human and mouse data.PubMedPubMedCentral
57.
Zurück zum Zitat • Smeekens JM, Immormino RM, Balogh PA, Randell SH, Kulis MD, Moran TP. Indoor dust acts as an adjuvant to promote sensitization to peanut through the airway. Clin Exp Allergy. 2019;49:1500–11. A mouse model demonstrating sensitization to peanut through the airway by co-administration of peanut and household dust, supporting the role of environmental adjuvants in non-oral sensitization.PubMedPubMedCentral • Smeekens JM, Immormino RM, Balogh PA, Randell SH, Kulis MD, Moran TP. Indoor dust acts as an adjuvant to promote sensitization to peanut through the airway. Clin Exp Allergy. 2019;49:1500–11. A mouse model demonstrating sensitization to peanut through the airway by co-administration of peanut and household dust, supporting the role of environmental adjuvants in non-oral sensitization.PubMedPubMedCentral
58.
Zurück zum Zitat Dolence JJ, Kobayashi T, Iijima K, Krempski J, Drake LY, Dent AL, et al. Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice. J Allergy Clin Immunol. 2018;142:1144-58.e8.PubMed Dolence JJ, Kobayashi T, Iijima K, Krempski J, Drake LY, Dent AL, et al. Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice. J Allergy Clin Immunol. 2018;142:1144-58.e8.PubMed
59.
Zurück zum Zitat Smeekens JM, Immormino RM, Kulis MD, Moran TP. Timing of exposure to environmental adjuvants is critical to mitigate peanut allergy. J Allergy Clin Immunol. 2021;147:387-90.e4.PubMed Smeekens JM, Immormino RM, Kulis MD, Moran TP. Timing of exposure to environmental adjuvants is critical to mitigate peanut allergy. J Allergy Clin Immunol. 2021;147:387-90.e4.PubMed
60.
Zurück zum Zitat Aitoro R, Paparo L, Amoroso A, Di Costanzo M, Cosenza L, Granata V, et al. Gut microbiota as a target for preventive and therapeutic intervention against food allergy. Nutrients. 2017;9. Aitoro R, Paparo L, Amoroso A, Di Costanzo M, Cosenza L, Granata V, et al. Gut microbiota as a target for preventive and therapeutic intervention against food allergy. Nutrients. 2017;9.
61.
Zurück zum Zitat Brough HA, Lanser BJ, Sindher SB, Teng JMC, Leung DYM, Venter C, et al. Early intervention and prevention of allergic diseases. Allergy. 2022;77:416–41.PubMed Brough HA, Lanser BJ, Sindher SB, Teng JMC, Leung DYM, Venter C, et al. Early intervention and prevention of allergic diseases. Allergy. 2022;77:416–41.PubMed
62.
Zurück zum Zitat Baek JH, Shin YH, Chung IH, Kim HJ, Yoo EG, Yoon JW, et al. The link between serum vitamin D level, sensitization to food allergens, and the severity of atopic dermatitis in infancy. J Pediatr. 2014;165:849-54.e1.PubMed Baek JH, Shin YH, Chung IH, Kim HJ, Yoo EG, Yoon JW, et al. The link between serum vitamin D level, sensitization to food allergens, and the severity of atopic dermatitis in infancy. J Pediatr. 2014;165:849-54.e1.PubMed
63.
Zurück zum Zitat Allen KJ, Koplin JJ, Ponsonby AL, Gurrin LC, Wake M, Vuillermin P, et al. Vitamin D insufficiency is associated with challenge-proven food allergy in infants. J Allergy Clin Immunol. 2013;131(1109–16):16.e1-6. Allen KJ, Koplin JJ, Ponsonby AL, Gurrin LC, Wake M, Vuillermin P, et al. Vitamin D insufficiency is associated with challenge-proven food allergy in infants. J Allergy Clin Immunol. 2013;131(1109–16):16.e1-6.
64.
Zurück zum Zitat Weisse K, Winkler S, Hirche F, Herberth G, Hinz D, Bauer M, et al. Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. Allergy. 2013;68:220–8.PubMed Weisse K, Winkler S, Hirche F, Herberth G, Hinz D, Bauer M, et al. Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. Allergy. 2013;68:220–8.PubMed
65.
Zurück zum Zitat Mullins RJ, Camargo CA. Latitude, sunlight, vitamin D, and childhood food allergy/anaphylaxis. Curr Allergy Asthma Rep. 2012;12:64–71.PubMed Mullins RJ, Camargo CA. Latitude, sunlight, vitamin D, and childhood food allergy/anaphylaxis. Curr Allergy Asthma Rep. 2012;12:64–71.PubMed
66.
Zurück zum Zitat Vassallo MF, Camargo CA. Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children. J Allergy Clin Immunol. 2010;126:217–22.PubMed Vassallo MF, Camargo CA. Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children. J Allergy Clin Immunol. 2010;126:217–22.PubMed
67.
Zurück zum Zitat Papathoma E, Triga M, Fouzas S, Dimitriou G. Cesarean section delivery and development of food allergy and atopic dermatitis in early childhood. Pediatr Allergy Immunol. 2016;27:419–24.PubMed Papathoma E, Triga M, Fouzas S, Dimitriou G. Cesarean section delivery and development of food allergy and atopic dermatitis in early childhood. Pediatr Allergy Immunol. 2016;27:419–24.PubMed
68.
Zurück zum Zitat Wypych TP, Marsland BJ. Antibiotics as instigators of microbial dysbiosis: implications for asthma and allergy. Trends Immunol. 2018;39:697–711.PubMed Wypych TP, Marsland BJ. Antibiotics as instigators of microbial dysbiosis: implications for asthma and allergy. Trends Immunol. 2018;39:697–711.PubMed
69.
Zurück zum Zitat Grimshaw KE, Maskell J, Oliver EM, Morris RC, Foote KD, Mills EN, et al. Diet and food allergy development during infancy: birth cohort study findings using prospective food diary data. J Allergy Clin Immunol. 2014;133:511–9.PubMed Grimshaw KE, Maskell J, Oliver EM, Morris RC, Foote KD, Mills EN, et al. Diet and food allergy development during infancy: birth cohort study findings using prospective food diary data. J Allergy Clin Immunol. 2014;133:511–9.PubMed
70.
Zurück zum Zitat Peters RL, Allen KJ, Dharmage SC, Lodge CJ, Koplin JJ, Ponsonby AL, et al. Differential factors associated with challenge-proven food allergy phenotypes in a population cohort of infants: a latent class analysis. Clin Exp Allergy. 2015;45:953–63.PubMed Peters RL, Allen KJ, Dharmage SC, Lodge CJ, Koplin JJ, Ponsonby AL, et al. Differential factors associated with challenge-proven food allergy phenotypes in a population cohort of infants: a latent class analysis. Clin Exp Allergy. 2015;45:953–63.PubMed
71.
Zurück zum Zitat Goldberg MR, Mor H, Magid Neriya D, Magzal F, Muller E, Appel MY, et al. Microbial signature in IgE-mediated food allergies. Genome Med. 2020;12:92.PubMedPubMedCentral Goldberg MR, Mor H, Magid Neriya D, Magzal F, Muller E, Appel MY, et al. Microbial signature in IgE-mediated food allergies. Genome Med. 2020;12:92.PubMedPubMedCentral
72.
Zurück zum Zitat • Feehley T, Plunkett CH, Bao R, Choi Hong SM, Culleen E, Belda-Ferre P, et al. Healthy infants harbor intestinal bacteria that protect against food allergy. Nat Med. 2019;25:448–53. Germ-free mice colonized with the fecal microbiome from cow’s milk allergic infants were sensitized to milk allergens while the fecal microbiome from healthy infants protected mice from sensitization.PubMedPubMedCentral • Feehley T, Plunkett CH, Bao R, Choi Hong SM, Culleen E, Belda-Ferre P, et al. Healthy infants harbor intestinal bacteria that protect against food allergy. Nat Med. 2019;25:448–53. Germ-free mice colonized with the fecal microbiome from cow’s milk allergic infants were sensitized to milk allergens while the fecal microbiome from healthy infants protected mice from sensitization.PubMedPubMedCentral
73.
Zurück zum Zitat Ling Z, Li Z, Liu X, Cheng Y, Luo Y, Tong X, et al. Altered fecal microbiota composition associated with food allergy in infants. Appl Environ Microbiol. 2014;80:2546–54.PubMedPubMedCentral Ling Z, Li Z, Liu X, Cheng Y, Luo Y, Tong X, et al. Altered fecal microbiota composition associated with food allergy in infants. Appl Environ Microbiol. 2014;80:2546–54.PubMedPubMedCentral
74.
Zurück zum Zitat Bunyavanich S, Shen N, Grishin A, Wood R, Burks W, Dawson P, et al. Early-life gut microbiome composition and milk allergy resolution. J Allergy Clin Immunol. 2016;138:1122–30.PubMedPubMedCentral Bunyavanich S, Shen N, Grishin A, Wood R, Burks W, Dawson P, et al. Early-life gut microbiome composition and milk allergy resolution. J Allergy Clin Immunol. 2016;138:1122–30.PubMedPubMedCentral
75.
Zurück zum Zitat Berni Canani R, Sangwan N, Stefka AT, Nocerino R, Paparo L, Aitoro R, et al. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants. ISME J. 2016;10:742–50.PubMed Berni Canani R, Sangwan N, Stefka AT, Nocerino R, Paparo L, Aitoro R, et al. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants. ISME J. 2016;10:742–50.PubMed
76.
Zurück zum Zitat Fujimura KE, Sitarik AR, Havstad S, Lin DL, Levan S, Fadrosh D, et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med. 2016;22:1187–91.PubMedPubMedCentral Fujimura KE, Sitarik AR, Havstad S, Lin DL, Levan S, Fadrosh D, et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med. 2016;22:1187–91.PubMedPubMedCentral
77.
Zurück zum Zitat Zhang L, Chun Y, Ho HE, Arditi Z, Lo T, Sajja S, et al. Multiscale study of the oral and gut environments in children with high- and low-threshold peanut allergy. J Allergy Clin Immunol. 2022;150:714-20.e2.PubMed Zhang L, Chun Y, Ho HE, Arditi Z, Lo T, Sajja S, et al. Multiscale study of the oral and gut environments in children with high- and low-threshold peanut allergy. J Allergy Clin Immunol. 2022;150:714-20.e2.PubMed
78.
Zurück zum Zitat Ho HE, Chun Y, Jeong S, Jumreornvong O, Sicherer SH, Bunyavanich S. Multidimensional study of the oral microbiome, metabolite, and immunologic environment in peanut allergy. J Allergy Clin Immunol. 2021;148:627-32.e3.PubMedPubMedCentral Ho HE, Chun Y, Jeong S, Jumreornvong O, Sicherer SH, Bunyavanich S. Multidimensional study of the oral microbiome, metabolite, and immunologic environment in peanut allergy. J Allergy Clin Immunol. 2021;148:627-32.e3.PubMedPubMedCentral
79.
Zurück zum Zitat Joseph CL, Sitarik AR, Kim H, Huffnagle G, Fujimura K, Yong GJM, et al. Infant gut bacterial community composition and food-related manifestation of atopy in early childhood. Pediatr Allergy Immunol. 2022;33:e13704.PubMed Joseph CL, Sitarik AR, Kim H, Huffnagle G, Fujimura K, Yong GJM, et al. Infant gut bacterial community composition and food-related manifestation of atopy in early childhood. Pediatr Allergy Immunol. 2022;33:e13704.PubMed
80.
Zurück zum Zitat Bao R, Hesser LA, He Z, Zhou X, Nadeau KC, Nagler CR. Fecal microbiome and metabolome differ in healthy and food-allergic twins. J Clin Invest. 2021;131. Bao R, Hesser LA, He Z, Zhou X, Nadeau KC, Nagler CR. Fecal microbiome and metabolome differ in healthy and food-allergic twins. J Clin Invest. 2021;131.
81.
Zurück zum Zitat Hourihane JO, Dean TP, Warner JO. Peanut allergy in relation to heredity, maternal diet, and other atopic diseases: results of a questionnaire survey, skin prick testing, and food challenges. BMJ. 1996;313:518–21.PubMedPubMedCentral Hourihane JO, Dean TP, Warner JO. Peanut allergy in relation to heredity, maternal diet, and other atopic diseases: results of a questionnaire survey, skin prick testing, and food challenges. BMJ. 1996;313:518–21.PubMedPubMedCentral
82.
Zurück zum Zitat Sicherer SH, Furlong TJ, Maes HH, Desnick RJ, Sampson HA, Gelb BD. Genetics of peanut allergy: a twin study. J Allergy Clin Immunol. 2000;106:53–6.PubMed Sicherer SH, Furlong TJ, Maes HH, Desnick RJ, Sampson HA, Gelb BD. Genetics of peanut allergy: a twin study. J Allergy Clin Immunol. 2000;106:53–6.PubMed
84.
Zurück zum Zitat Tsai HJ, Kumar R, Pongracic J, Liu X, Story R, Yu Y, et al. Familial aggregation of food allergy and sensitization to food allergens: a family-based study. Clin Exp Allergy. 2009;39:101–9.PubMed Tsai HJ, Kumar R, Pongracic J, Liu X, Story R, Yu Y, et al. Familial aggregation of food allergy and sensitization to food allergens: a family-based study. Clin Exp Allergy. 2009;39:101–9.PubMed
85.
Zurück zum Zitat Kanchan K, Grinek S, Bahnson HT, Ruczinski I, Shankar G, Larson D, et al. HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy. J Clin Invest. 2022;132. Kanchan K, Grinek S, Bahnson HT, Ruczinski I, Shankar G, Larson D, et al. HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy. J Clin Invest. 2022;132.
86.
Zurück zum Zitat Huffaker MF, Kanchan K, Bahnson HT, Baloh C, Lack G, Nepom GT, et al. Incorporating genetics in identifying peanut allergy risk and tailoring allergen immunotherapy: a perspective on the genetic findings from the LEAP trial. J Allergy Clin Immunol. 2023;151:841–7.PubMed Huffaker MF, Kanchan K, Bahnson HT, Baloh C, Lack G, Nepom GT, et al. Incorporating genetics in identifying peanut allergy risk and tailoring allergen immunotherapy: a perspective on the genetic findings from the LEAP trial. J Allergy Clin Immunol. 2023;151:841–7.PubMed
87.
Zurück zum Zitat Zhou X, Han X, Lyu SC, Bunning B, Kost L, Chang I, et al. Targeted DNA methylation profiling reveals epigenetic signatures in peanut allergy. JCI Insight. 2021;6. Zhou X, Han X, Lyu SC, Bunning B, Kost L, Chang I, et al. Targeted DNA methylation profiling reveals epigenetic signatures in peanut allergy. JCI Insight. 2021;6.
Metadaten
Titel
Environmental Exposure to Foods as a Risk Factor for Food Allergy
verfasst von
Andrew V. Turner
Johanna M. Smeekens
Publikationsdatum
25.05.2023
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 8/2023
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-023-01091-0

Weitere Artikel der Ausgabe 8/2023

Current Allergy and Asthma Reports 8/2023 Zur Ausgabe

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

29.05.2024 Larynxkarzinom Nachrichten

Fast ein Viertel der Personen mit mäßig dysplastischen Stimmlippenläsionen entwickelt einen Kehlkopftumor. Solche Personen benötigen daher eine besonders enge ärztliche Überwachung.

Hörschwäche erhöht Demenzrisiko unabhängig von Beta-Amyloid

29.05.2024 Hörstörungen Nachrichten

Hört jemand im Alter schlecht, nimmt das Hirn- und Hippocampusvolumen besonders schnell ab, was auch mit einem beschleunigten kognitiven Abbau einhergeht. Und diese Prozesse scheinen sich unabhängig von der Amyloidablagerung zu ereignen.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Betalaktam-Allergie: praxisnahes Vorgehen beim Delabeling

16.05.2024 Pädiatrische Allergologie Nachrichten

Die große Mehrheit der vermeintlichen Penicillinallergien sind keine. Da das „Etikett“ Betalaktam-Allergie oft schon in der Kindheit erworben wird, kann ein frühzeitiges Delabeling lebenslange Vorteile bringen. Ein Team von Pädiaterinnen und Pädiatern aus Kanada stellt vor, wie sie dabei vorgehen.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.