nach oben

Lasers in Medical Science

Erschienen in:

01.12.2024 | Original Article

Evaluation of changes in macular structures after subthreshold micropulse laser therapy on chronic central serous chorioretinopathy

verfasst von: Lijun Liu, Qian Xu, Xian Song, Yuqing Zhao, Yu Zhang, Yi Qu

Erschienen in: Lasers in Medical Science | Ausgabe 1/2024

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To evaluate the changes in macular structures following subthreshold micropulse laser (SHML) treatment for chronic central serous chorioretinopathy (cCSC).

Methods

Data of 33 eyes from 31 cCSC patients treated with SHML and followed up for at least 6 months has been included in this retrospective study. Main outcome measurements include resolution of subretinal fluid (SRF) and pigment epithelial detachment (PED), the recovery of ellipsoid zone (EZ) continuity, and the foveal outer nuclear layer (ONL) thickness along with its ratio.

Results

Mean observation period is 7.355 months (ranging from 6 to 24 months) and mean number of treatments administered is 1.839 (ranging from 1 to 5). 6 months after SHML treatment, there is a significant decrease in the area of SRF and PED (P < 0.001, P = 0.010, respectively). Additionally, the frequency of continuous EZ and the foveal ONL thickness reveal a significant increase (P<0.001, P = 0.005, respectively). The ratio of foveal ONL thickness is significantly higher after laser treatment, particularly in patients with a disease duration of ≤12 months (p = 0.022, P=0.036, respectively).

Conclusion

SHML treatment proves to be effective in cCSC eyes, leading to satisfactory recovery of macular structures, especially the photoreceptor layer.

Kaye R, Chandra S, Sheth J, Boon CJF, Sivaprasad S, Lotery A (2020) Central serous chorioretinopathy: an update on risk factors, pathophysiology and imaging modalities. Prog Retin Eye Res 79:100865 Epub 2020/05/15. https://doi.org/10.1016/j.preteyeres.2020.100865CrossRefPubMed

Bazzazi N, Ahmadpanah M, Akbarzadeh S, Seif Rabiei MA, Holsboer-Trachsler E, Brand S (2015) In patients suffering from idiopathic central serous chorioretinopathy, anxiety scores are higher than in healthy controls, but do not vary according to sex or repeated central serous chorioretinopathy. Neuropsychiatr Dis Treat 11:1131–1136 Epub 2015/05/23. https://doi.org/10.2147/ndt.S83216CrossRefPubMedPubMedCentral

Haimovici R, Koh S, Gagnon DR, Lehrfeld T, Wellik S (2004) Risk factors for central serous chorioretinopathy: a case-control study. Ophthalmology 111(2):244–249 Epub 2004/03/17. https://doi.org/10.1016/j.ophtha.2003.09CrossRefPubMed

Liu B, Deng T, Zhang J, RISK FACTORS FOR CENTRAL SEROUS (2016) CHORIORETINOPATHY: a systematic review and Meta-analysis. Retina (Philadelphia Pa) 36(1):9–19 Epub 2015/12/29. https://doi.org/10.1097/iae.0000000000000837CrossRefPubMed

van Rijssen TJ, van Dijk EHC, Yzer S, Ohno-Matsui K, Keunen JEE, Schlingemann RO et al (2019) Central serous chorioretinopathy: towards an evidence-based treatment guideline. Prog Retin Eye Res 73:100770 PubMed PMID: 31319157CrossRefPubMed

Nicholson B, Noble J, Forooghian F, Meyerle C (2013) Central serous chorioretinopathy: update on pathophysiology and treatment. Surv Ophthalmol 58(2):103–126 Epub 2013/02/16. https://doi.org/10.1016/j.survophthal.2012.07.004CrossRefPubMedPubMedCentral

Yu J, Ye X, Li L, Chang Q, Jiang C (2021) Relationship between photoreceptor layer changes before half-dose photodynamic therapy and functional and anatomic outcomes in central serous chorioretinopathy. Eye 35(3):1002–1010 Epub 2020/06/18. https://doi.org/10.1038/s41433-020-1018-6CrossRefPubMed

Robertson DM (1986) Argon laser photocoagulation treatment in central serous chorioretinopathy. Ophthalmology 93(7):972–974 Epub 1986/07/01. doi: 10.1016/s0161-6420(86)33652-2. PubMed PMID: 3531957CrossRefPubMed

Robertson DM, Ilstrup D (1983) Direct, indirect, and sham laser photocoagulation in the management of central serous chorioretinopathy. Am J Ophthalmol 95(4):457–466 Epub 1983/04/01. https://doi.org/10.1016/0002-9394(83)90265-9CrossRefPubMed

10.

Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N et al (2015) Central serous chorioretinopathy: recent findings and new physiopathology hypothesis. Prog Retin Eye Res 48:82–118 Epub 2015/06/01. https://doi.org/10.1016/j.preteyeres.2015.05.003CrossRefPubMed

11.

van Dijk EHC, Fauser S, Breukink MB, Blanco-Garavito R, Groenewoud JMM, Keunen JEE et al (2018) Half-dose photodynamic therapy versus high-density Subthreshold Micropulse Laser treatment in patients with Chronic Central Serous Chorioretinopathy: the PLACE trial. Ophthalmology 125(10):1547–1555 Epub 2018/05/20. https://doi.org/10.1016/j.ophtha.2018.04.021CrossRefPubMed

12.

Reibaldi M, Cardascia N, Longo A, Furino C, Avitabile T, Faro S et al (2010) Standard-fluence versus low-fluence photodynamic therapy in chronic central serous chorioretinopathy: a nonrandomized clinical trial. American journal of ophthalmology. ;149(2):307 – 15.e2. Epub 2009/11/10. doi: 10.1016/j.ajo.2009.08.026. PubMed PMID: 19896635

13.

Lim JI, Glassman AR, Aiello LP, Chakravarthy U, Flaxel CJ, Spaide RF (2014) Collaborative retrospective macula society study of photodynamic therapy for chronic central serous chorioretinopathy. Ophthalmology 121(5):1073–1078 PubMed PMID: 24439758CrossRefPubMed

14.

Kang HM, Choi JH, Koh HJ, Lee SC (2020) Long-term treatment response after intravitreal bevacizumab injections for patients with central serous chorioretinopathy. PLoS One. ;15(9):e0238725. Epub 2020/09/09. https://doi.org/10.1371/journal.pone.0238725. PubMed PMID: 32898167; PubMed Central PMCID: PMCPMC7478837 institute does not involve in conducting this study. Choikang Seoul Eye Clinic does not have any role in the design or conduct of this research. There was no other conflict of Interest for each author. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no relevant patents, marketed products, or products in development to declare

15.

Chen SN, Hwang JF, Tseng LF, Lin CJ (2008) Subthreshold diode micropulse photocoagulation for the treatment of chronic central serous chorioretinopathy with juxtafoveal leakage. Ophthalmology 115(12):2229–2234 Epub 2008/12/02. https://doi.org/10.1016/j.ophtha.2008.08.026CrossRefPubMed

16.

Sivaprasad S, Elagouz M, McHugh D, Shona O, Dorin G (2010) Micropulsed diode laser therapy: evolution and clinical applications. Surv Ophthalmol 55(6):516–530 PubMed PMID: 20850854CrossRefPubMed

17.

Roca JA, Wu L, Fromow-Guerra J, Rodríguez FJ, Berrocal MH, Rojas S et al (2018) Yellow (577 nm) micropulse laser versus half-dose verteporfin photodynamic therapy in eyes with chronic central serous chorioretinopathy: results of the pan-american collaborative retina study (PACORES) Group. Br J Ophthalmol 102(12):1696–1700 Epub 2018/02/14. https://doi.org/10.1136/bjophthalmol-2017-311291CrossRefPubMed

18.

Han J, Cho NS, Kim K, Kim ES, Kim DG, Kim JM et al (2020) FUNDUS AUTOFLUORESCENCE PATTERNS IN CENTRAL SEROUS CHORIORETINOPATHY. Retina (Philadelphia. Pa) 40(7):1387–1394 Epub 2019/06/04. https://doi.org/10.1097/iae.0000000000002580CrossRef

19.

Uzlu D, Erdöl H, Kola M, Özbay AD (2021) The efficacy of subthreshold micropulse yellow laser (577 nm) in chronic central serous chorioretinopathy. Lasers Med Sci 36(5):981–988 Epub 2020/08/20. https://doi.org/10.1007/s10103-020-03129-5CrossRefPubMed

20.

Cook B, Lewis GP, Fisher SK, Adler R (1995) Apoptotic photoreceptor degeneration in experimental retinal detachment. Investig Ophthalmol Vis Sci 36(6):990–996 Epub 1995/05/01. PubMed PMID: 7730033

21.

Hwang S, Kang SW, Kim SJ, Jang JW, Kim KT, PHOTODYNAMIC THERAPY FOR SYMPTOMATIC SUBFOVEAL RETINAL PIGMENT, EPITHELIAL DETACHMENT IN CENTRAL SEROUS CHORIORETINOPATHY (2019) Outcomes and prognostic factors. Retina (Philadelphia Pa) 39(6):1117–1124 Epub 2018/03/09. https://doi.org/10.1097/iae.0000000000002108CrossRefPubMed

22.

Feenstra HMA, Hahn LC, van Rijssen TJ, Tsonaka R, Breukink MB, Keunen JEE, EFFICACY OF HALF-DOSE PHOTODYNAMIC THERAPY VERSUS HIGH-DENSITY SUBTHRESHOLD MICROPULSE LASER FOR TREATING PIGMENT EPITHELIAL DETACHMENTS IN CHRONIC CENTRAL SEROUS CHORIORETINOPATHY et al (2022) Retina (Philadelphia Pa) 42(4):721–729 Epub 2021/12/06. https://doi.org/10.1097/iae.0000000000003363CrossRefPubMed

23.

Sramek C, Mackanos M, Spitler R, Leung LS, Nomoto H, Contag CH et al (2011) Non-damaging retinal phototherapy: dynamic range of heat shock protein expression. Investig Ophthalmol Vis Sci 52(3):1780–1787 Epub 2010/11/20. https://doi.org/10.1167/iovs.10-5917CrossRef

24.

Strauss O (2005) The retinal pigment epithelium in visual function. Physiol Rev 85(3):845–881 Epub 2005/07/01. https://doi.org/10.1152/physrev.00021.2004CrossRefPubMed

25.

Litts KM, Zhang Y, Freund KB, Curcio CA, OPTICAL COHERENCE TOMOGRAPHY AND HISTOLOGY OF AGE-RELATED MACULAR DEGENERATION SUPPORT, MITOCHONDRIA AS REFLECTIVITY SOURCES, Retina, Philadelphia (2018) Pa) 38(3):445–461 Epub 2017/12/07. https://doi.org/10.1097/iae.0000000000001946CrossRef

26.

Figueiredo N, Sarraf D, Gunnemann F, Sadda SR, Bansal A, Berger AR et al (2022) Longitudinal Assessment of Ellipsoid Zone Recovery using En face Optical Coherence Tomography after Retinal Detachment Repair. Am J Ophthalmol 236:212–220 Epub 2021/10/26. https://doi.org/10.1016/j.ajo.2021.10.012CrossRefPubMed

27.

Matsumoto H, Sato T, Kishi S (2009) Outer nuclear layer thickness at the fovea determines visual outcomes in resolved central serous chorioretinopathy. Am J Ophthalmol 148(1):105–10e1. https://doi.org/10.1016/j.ajo.2009.01.018. Epub 2009/03/31. PubMed PMID: 19327740CrossRefPubMed

28.

Yu J, Ye X, Li L, Jiang C, Chang Q, Xu G (2021) Threshold thickness of foveal outer nuclear layer associated with outcomes of photodynamic therapy in central serous chorioretinopathy. Eye. Epub 2021/09/05 https://doi.org/10.1038/s41433-021-01762-0CrossRefPubMedPubMedCentral

29.

Deng K, Gui Y, Cai Y, Liang Z, Shi X, Sun Y et al (2021) Changes in the foveal outer nuclear layer of Central Serous Chorioretinopathy patients over the Disease Course and their response to photodynamic therapy. Front Med 8:824239 Epub 2022/02/01. https://doi.org/10.3389/fmed.2021.824239CrossRef

30.

Yu J, Lei Y, Chang Q, Xu G, Ye X, Li L et al (2019) The relationship between foveal outer nuclear layer thickness in the active and resolved phases of central serous chorioretinopathy treated with half-dose photodynamic therapy. BMC Ophthalmol 19(1):84 Epub 2019/03/30. https://doi.org/10.1186/s12886-019-1089-yCrossRefPubMedPubMedCentral

31.

Mrejen S, Balaratnasingam C, Kaden TR, Bottini A, Dansingani K, Bhavsar KV et al (2019) Long-term visual outcomes and causes of Vision loss in Chronic Central Serous Chorioretinopathy. Ophthalmology 126(4):576–588 Epub 2019/01/20. https://doi.org/10.1016/j.ophtha.2018.12.048CrossRefPubMed

Titel: Evaluation of changes in macular structures after subthreshold micropulse laser therapy on chronic central serous chorioretinopathy
verfasst von: Lijun Liu
Qian Xu
Xian Song
Yuqing Zhao
Yu Zhang
Yi Qu
Publikationsdatum: 01.12.2024
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 1/2024
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-024-04030-1

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Evaluation of changes in macular structures after subthreshold micropulse laser therapy on chronic central serous chorioretinopathy

Abstract

Purpose

Methods

Results

Conclusion

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2024

Effect of photobiomodulation therapy on the morphology, intracellular calcium concentration, free radical generation, apoptosis and necrosis of human mesenchymal stem cells—an in vitro study

Effect of various photobiomodulation regimens on breast cancer-related lymphedema: A systematic review and meta-analysis

Enhancing tumor’s skin photothermal therapy using Gold nanoparticles : a Monte Carlo simulation

Fluorescent microscopy evaluation of diode laser effect on the penetration depth of turmeric (Curcuma longa) extract cream on skin tissues of Wistar rats

308 nm excimer laser and tacrolimus ointment in the treatment of facial vitiligo: a systematic review and meta-analysis

Ablative fractional laser treatment reduces hedgehog pathway gene expression in murine basal cell carcinomas