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06.09.2023 | Review

Facial expression recognition deficits in frontotemporal dementia and Alzheimer’s disease: a meta-analytic investigation of effects of phenotypic variant, task modality, geographical region and symptomatic specificity

verfasst von: Daphne Stam, Simon Rosseel, François-Laurent De Winter, Maarten J. A. Van den Bossche, Mathieu Vandenbulcke, Jan Van den Stock

Erschienen in: Journal of Neurology | Ausgabe 12/2023

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Abstract

Deficits in social cognition may be present in frontotemporal dementia (FTD) and Alzheimer’s disease (AD). Here, we conduct a qualitative synthesis and meta-analysis of facial expression recognition studies in which we compare the deficits between both disorders. Furthermore, we investigate the specificity of the deficit regarding phenotypic variant, domain-specificity, emotion category, task modality, and geographical region. The results reveal that both FTD and AD are associated with facial expression recognition deficits, that this deficit is more pronounced in FTD compared to AD and that this applies for the behavioral as well as for language FTD-variants, with no difference between the latter two. In both disorders, overall emotion recognition was most frequently impaired, followed by recognition of anger in FTD and by fear in AD. Verbal categorization was the most frequently used task, although matching or intensity rating tasks may be more specific. Studies from Oceania revealed larger deficits. On the other hand, non-emotional control tasks were more impacted by AD than by FTD. The present findings sharpen the social cognitive phenotype of FTD and AD, and support the use of social cognition assessment in late-life neuropsychiatric disorders.

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Titel: Facial expression recognition deficits in frontotemporal dementia and Alzheimer’s disease: a meta-analytic investigation of effects of phenotypic variant, task modality, geographical region and symptomatic specificity
verfasst von: Daphne Stam
Simon Rosseel
François-Laurent De Winter
Maarten J. A. Van den Bossche
Mathieu Vandenbulcke
Jan Van den Stock
Publikationsdatum: 06.09.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 12/2023
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-023-11927-4

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