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18.06.2021 | Sleep Breathing Physiology and Disorders • Original Article

High-flow nasal cannula compared with continuous positive airway pressure in the treatment of obstructive sleep apnea

verfasst von: Chung-Chieh Yu, Chih-Yu Huang, Chung-Ching Hua, Huang-Pin Wu

Erschienen in: Sleep and Breathing | Ausgabe 2/2022

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Abstract

Purpose

Continuous positive airway pressure (CPAP) is a standard treatment for obstructive sleep apnea (OSA). However, CPAP has limitations. High-flow nasal cannula (HFNC) is already in use for various types of respiratory diseases. As HFNC generates positive airway pressure, it may be a potential candidate for OSA treatment. This prospective study compared the therapeutic effects of HFNC to CPAP in patients with OSA.

Methods

Patients whose apnea–hypopnea index (AHI) was > 5 events/h were enrolled in this study. All participants were randomly divided into two groups. The first group underwent CPAP the first night and HFNC the second night. Conversely, the second group received HFNC the first night and CPAP the second night. Their respiratory events and sleep quality were compared using baseline polysomnography, CPAP, and HFNC.

Results

In total, 28 participants completed this study. Median [interquartile range] AHI (35.0 [20.0–48.6] vs. 10.8 [5.5–20.6] events/h; p < 0.001) was significantly improved by the HFNC. However, sleep quality was not improved. When CPAP was compared directly with HFNC, CPAP demonstrated a more favorable effect for respiratory events (AHI 5.0 [2.0–7.0] vs. 10.8 [5.5–20.6] events/h; p < 0.001) and sleep efficiency (88.1 [79.9–92.5] vs. 77.9 [69.2–86.6] %; p = 0.001).

Conclusion

The efficacy of CPAP was superior to HFNC for both respiratory events and sleep quality.

Trial registration

ClinicalTrials.gov Identifier: NCT03843372; URL: www.clinicaltrials.gov; Date of registration: November 2, 2019

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Titel: High-flow nasal cannula compared with continuous positive airway pressure in the treatment of obstructive sleep apnea
verfasst von: Chung-Chieh Yu
Chih-Yu Huang
Chung-Ching Hua
Huang-Pin Wu
Publikationsdatum: 18.06.2021
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 2/2022
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02413-0

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High-flow nasal cannula compared with continuous positive airway pressure in the treatment of obstructive sleep apnea