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Head and Neck Pathology
Erschienen in: Head and Neck Pathology 1/2023

07.11.2022 | Review

Homeobox Genes in Odontogenic Lesions: A Scoping Review

verfasst von: Erica Pey Wen Hii, Anand Ramanathan, Anitha Krishnan Pandarathodiyil, Gou Rean Wong, E. V. Soma Sekhar, Rozaidah Binti Talib, Zuraiza Mohamad Zaini, Rosnah Binti Zain

Erschienen in: Head and Neck Pathology | Ausgabe 1/2023

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Abstract

Background

Homeobox genes play crucial roles in tooth morphogenesis and development and thus mutations in homeobox genes cause developmental disorders such as odontogenic lesions. The aim of this scoping review is to identify and compile available data from the literatures on the topic of homeobox gene expression in odontogenic lesions.

Method

An electronic search to collate all the information on studies on homeobox gene expression in odontogenic lesions was carried out in four databases (PubMed, EBSCO host, Web of Science and Cochrane Library) with selected keywords. All papers which reported expression of homeobox genes in odontogenic lesions were considered.

Results

A total of eleven (11) papers describing expression of homeobox genes in odontogenic lesions were identified. Methods of studies included next generation sequencing, microarray analysis, RT-PCR, Western blotting, in situ hybridization, and immunohistochemistry. The homeobox reported in odontogenic lesions includes LHX8 and DLX3 in odontoma; PITX2, MSX1, MSX2, DLX, DLX2, DLX3, DLX4, DLX5, DLX6, ISL1, OCT4 and HOX C in ameloblastoma; OCT4 in adenomatoid odontogenic tumour; PITX2 and MSX2 in primordial odontogenic tumour; PAX9 and BARX1 in odontogenic keratocyst; PITX2, ZEB1 and MEIS2 in ameloblastic carcinoma while there is absence of DLX2, DLX3 and MSX2 in clear cell odontogenic carcinoma.

Conclusions

This paper summarized and reviews the possible link between homeobox gene expression in odontogenic lesions. Based on the current available data, there are insufficient evidence to support any definite role of homeobox gene in odontogenic lesions.
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Metadaten
Titel
Homeobox Genes in Odontogenic Lesions: A Scoping Review
verfasst von
Erica Pey Wen Hii
Anand Ramanathan
Anitha Krishnan Pandarathodiyil
Gou Rean Wong
E. V. Soma Sekhar
Rozaidah Binti Talib
Zuraiza Mohamad Zaini
Rosnah Binti Zain
Publikationsdatum
07.11.2022
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 1/2023
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-022-01481-2

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