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Erschienen in:

02.12.2022 | Original Article

Inhibitory Effect of Oroxylin A in a Mouse Model of Atopic Dermatitis

verfasst von: Ye-Ji Lee, Dong-Soon Im

Erschienen in: Inflammation | Ausgabe 2/2023

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Abstract

Scutellaria baicalensis has long been used in Asian traditional medicine to prevent and treat suppurative dermatitis, allergic diseases, inflammation, hyperlipemia, and arteriosclerosis. Oroxylin A is a flavone present in Scutellaria baicalensis. Because the root extracts of Scutellaria baicalensis have been shown to have anti-dermatitis effects, the authors investigated the effects of oroxylin A on chemically induced atopic dermatitis (AD) in an in vivo AD model induced by 1-chloro-2,4-dinitrobenzene (CDNB) in BALB/c mice. CDNB-induced skin hypertrophy and accumulation of mast cells in the epidermis and dermis were significantly decreased by oroxylin A. Increased serum levels of immunoglobulin E, as well as pro-inflammatory chemokines and cytokines in the skin and lymph nodes, were significantly decreased by oroxylin A. Suppression of immune responses in the skin and lymph nodes by oroxylin A decreased the symptoms of AD. Thus, these results proved that oroxylin A is an effective component of Scutellaria baicalensis for treating the symptoms of AD.

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Titel: Inhibitory Effect of Oroxylin A in a Mouse Model of Atopic Dermatitis
verfasst von: Ye-Ji Lee
Dong-Soon Im
Publikationsdatum: 02.12.2022
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 2/2023
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-022-01764-4

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