Inflammation OnlineFirst articles

18.05.2024 | RESEARCH

Resatorvid (TAK-242) Ameliorates Ulcerative Colitis by Modulating Macrophage Polarization and T Helper Cell Balance via TLR4/JAK2/STAT3 Signaling Pathway

Resatorvid (TAK-242), a specific inhibitor of Toll-like receptor-4 (TLR4), has attracted attention for its anti-inflammatory properties. Despite this, few studies have evaluated its effects on ulcerative colitis (UC). This study aimed to …

verfasst von:: Xiaoling Huang, Rong Lin, Huan Liu, Mengying Dai, Jiejie Guo, Wenjia Hui, Weidong Liu, Milamuguli Haerken, Ruixue Zheng, Tangnuer Yushanjiang, Feng Gao

18.05.2024 | RESEARCH

4-Octyl Itaconate Attenuates Neuroinflammation in Experimental Autoimmune Encephalomyelitis Via Regulating Microglia

Abnormal activation of microglia, the resident macrophages in the central nervous system, plays an important role in the pathogenesis of multiple sclerosis (MS). The immune responsive gene 1(IRG1)/itaconate axis is involved in regulating …

verfasst von:: Ning Zhao, Ming Yi, Lin-Jie Zhang, Qiu-Xia Zhang, Li Yang

18.05.2024 | RESEARCH

RBPJ Knockdown Promotes M2 Macrophage Polarization Through Mitochondrial ROS-mediated Notch1-Jagged1-Hes1 Signaling Pathway in Uveitis

Uveitis is an autoimmune eye disease that can be involved in the entire body and is one of the leading causes of blindness. Therefore, comprehending the mechanisms underlying the development and regulation of ocular immune responses in uveitis is …

verfasst von:: Ruyi Qu, Yuan Peng, Shuqin Xu, Mengxian Zhou, Xuewei Yin, Bin Liu, Hongsheng Bi, Dadong Guo

16.05.2024 | RESEARCH

Peripheral Blood Lymphocyte Subsets and Heterogeneity of B Cell Subsets in Patients of Idiopathic Inflammatory Myositis with Different Myositis-specific Autoantibodies

Idiopathic inflammatory myopathies (IIM) are a group of myopathies that present with muscle weakness and multiple extra-muscular manifestations, in which lymphocytes play central roles in myositis pathogenesis. This study aimed to explore the …

verfasst von:: Zhou Pan, Mengdi Li, Panpan Zhang, Tianqi Li, Rui Liu, Jia Liu, Shengyun Liu, Yusheng Zhang

13.05.2024 | RESEARCH

Oroxylin A-induced Trained Immunity Promotes LC3-associated Phagocytosis in Macrophage in Protecting Mice Against Sepsis

Sepsis is defined as a dysregulated host response to infection that leads to multiorgan failure. Innate immune memory, i.e., “trained immunity”, can result in stronger immune responses and provide protection against various infections. Many …

verfasst von:: Lijie Yin, Ziqian Bing, Yaojun Zheng, Yuchen Pan, Yue Dong, Jiali Wang, Renjie Luo, Yue Zhao, Huan Dou, Yayi Hou

13.05.2024 | RESEARCH

Acacetin Attenuates Sepsis-induced Acute Lung Injury via NLRC3-NF-κB Pathway

Acacetin, a flavonoid derived compound has been recognized for its diverse biological activities, such as anti-oxidative and anti-inflammatory effects. Acute lung injury (ALI) is a severe condition characterized by respiratory insufficiency and …

verfasst von:: Yingchou Xiao, Bo Zhang, Shiyuan Hou, Xing Shen, Xingan Wu, Rongrong Liu, Ying Luo

13.05.2024 | RESEARCH

Silencing DDX3 Attenuates Interleukin-1β-Induced Intervertebral Disc Degeneration Through Inhibiting Pyroptosis

Intervertebral disc degeneration (IVDD) is a common disorder associated with chronic inflammation and cell death. In this study, an IVDD rat model was created through Interleukin-1β (IL-1β) injection. The degeneration of intervertebral disc …

verfasst von:: Hongfa Zhong, Mingheng Li, Haijian Wu, Hui Ying, Mingliang Zhong, Mouzhang Huang

13.05.2024 | RESEARCH

Mass Spectrometry-Based Proteomics Analysis Unveils PTPRS Inhibits Proliferation and Inflammatory Response of Keratinocytes in Psoriasis

In this study, we used data-independent acquisition-mass spectrometry (DIA-MS) to analyze the serum proteome in psoriasis vulgaris (PsO). The serum proteomes of seven healthy controls and eight patients with PsO were analyzed using DIA-MS.

verfasst von:: Xuyu Zheng, Cui Zhou, Yulian Hu, Shihao Xu, Li Hu, Biyu Li, Xiaoqin Zhao, Qian Li, Xin Tang, Kun Huang

09.05.2024 | RESEARCH

Iron Overload–Dependent Ferroptosis Aggravates LPS-Induced Acute Lung Injury by Impairing Mitochondrial Function

Ferroptosis is a newly proposed form of programmed cell death that is iron-dependent and closely linked to oxidative stress. Its specific morphological changes include shrunken mitochondria, increased density of mitochondrial membrane, and rupture …

verfasst von:: Xiaocen Wang, Tingting Wei, Jinlong Luo, Ke Lang, Yansha Song, Xinyi Ning, Yencheng Chao, Zhaolin Gu, Linlin Wang, Cuicui Chen, Dong Yang, Yuanlin Song

Open Access 09.05.2024 | RESEARCH

Regulation of Alternative Splicing of Lipid Metabolism Genes in Sepsis-Induced Liver Damage by RNA-Binding Proteins

RNA binding proteins (RBPs) have the potential for transcriptional regulation in sepsis-induced liver injury, but precise functions remain unclear. Our aim is to conduct a genome-wide expression analysis of RBPs and illuminate changes in the …

verfasst von:: Buzukela Abuduaini, Zhang Jiyuan, Aliya Rehati, Zhao Liang, Song Yunlin

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08.05.2024 | RESEARCH

Gypenoside XLIX Activates the Sirt1/Nrf2 Signaling Pathway to Inhibit NLRP3 Inflammasome Activation to Alleviate Septic Acute Lung Injury

Currently, treatment options for acute lung injury (ALI) are limited. Gypenoside XLIX (Gyp-XLIX) is known for its anti-inflammatory properties, but there is a lack of extensive research on its effects against ALI. This study induced ALI in mice …

verfasst von:: Kaixin Ping, Rongrong Yang, Huizhen Chen, Shaocheng Xie, Yannan Xiang, Mengxin Li, Yingzhi Lu, Jingquan Dong

08.05.2024 | RESEARCH

Dual Regulation of Nicotine on NLRP3 Inflammasome in Macrophages with the Involvement of Lysosomal Destabilization, ROS and α7nAChR

Nicotine, the primary alkaloid in tobacco products, has been shown to have immunoregulatory function in at least 20 diseases. The biological mechanism of action of nicotine immunoregulation is complex, resulting in an improvement of some disease …

verfasst von:: Xiaqing Wu, Yushan Tian, Hongjuan Wang, Huan Chen, Hongwei Hou, Qingyuan Hu

07.05.2024 | RESEARCH

Esaxerenone Inhibits Interferon-γ Induced Pyroptosis of Macrophages in the Lungs of Aldosterone-treated Mice

Lung immune cells such as lymphocytes and macrophages can induce an inflammatory response due to the activation of mineralocorticoid receptor (MR), which is manifested by the infiltration of inflammatory cells and the secretion of inflammatory …

verfasst von:: Jingyue Chang, Xiaomeng Gao, Fan Yang, Panpan Qiang, Lili Fan, Ziqian Liu, Tatsuo Shimosawa, Qingyou Xu, Yi Chang

03.05.2024 | RESEARCH

TRPV1 Regulates Proinflammatory Properties of M1 Macrophages in Periodontitis Via NRF2

Periodontitis, characterized by progressive alveolar bone destruction, leads to the loss of attachment and stability of the affected teeth. Macrophages, especially the proinflammatory M1 subtype, are key in periodontitis pathogenesis, driving the …

verfasst von:: Yiyang Li, Xiaotong Guo, Peimeng Zhan, Shuheng Huang, Jiayao Chen, Yujie Zhou, Wentao Jiang, Lingling Chen, Zhengmei Lin

Open Access 03.05.2024 | RESEARCH

Targeted Demethylation of FOXP3-TSDR Enhances the Suppressive Capacity of STAT6-deficient Inducible T Regulatory Cells

In vitro induced T regulatory cells (iTregs) are promising for addressing inflammation-driven diseases. However, current protocols for the generation and expansion of iTregs fail to induce extensive demethylation of the Treg-specific demethylated …

verfasst von:: Rubén D. Arroyo-Olarte, Juan C. Flores-Castelán, Leonel Armas-López, Galileo Escobedo, Luis I. Terrazas, Federico Ávila-Moreno, Sonia Leon-Cabrera

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01.05.2024 | REVIEW

The Role of Macrophage Death in Periodontitis: A Review

Periodontitis, an infectious inflammatory disease influenced by various factors, disrupts the delicate balance between the host microbiota and immunity. The resulting excessive immune response exacerbates the progressive destruction of the …

verfasst von:: Wen Luo, Chengying Du, Hsiuwei Huang, Jie Kong, Ziming Ge, Li Lin, Hongyan Wang

01.05.2024 | Retraction Note

Retraction Note: Geniposide Attenuates LPS-Induced Injury via Up-Regulation of miR-145 in H9c2 Cells

verfasst von:: Qiang Su, Junjing Yao, Cunjian Sheng

27.04.2024 | RESEARCH

Inflammatory Protein Signatures as Predictive Disease-Specific Markers for Non-Alcoholic Steatohepatitis (NASH)

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic disease worldwide, consisting of a broad spectrum of diseases such as simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular …

verfasst von:: Nadella Mounika, Suraj Bhausaheb Mungase, Shivangi Verma, Savneet Kaur, Utpal Jyoti Deka, Tarini Shankar Ghosh, Ramu Adela

26.04.2024 | REVIEW

Bacillus Calmette-Guérin (BCG)-Induced Protection in Brain Disorders

The Bacille Calmette-Guerin (BCG) vaccine is one of the most widely used vaccines in the world for the prevention of tuberculosis. Its immunological capacity also includes epigenetic reprogramming, activation of T cells and inflammatory responses.

verfasst von:: Khiany Mathias, Richard Simon Machado, Solange Stork, Carla Damasio Martins, Amanda Christine da Silva Kursancew, Victória Linden de Rezende, Cinara Ludvig Gonçalves, Tatiana Barichello, Josiane Somariva Prophiro, Fabricia Petronilho

26.04.2024 | RESEARCH

Integrated Single Cell Analysis Reveals An Atlas of Tumor Associated Macrophages in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC), one of the most prevalent cancers globally, is closely associated with tumor-associated macrophages (TAMs), including monocyte-derived macrophages and liver-resident Kupffer cells. Understanding TAM heterogeneity at …

verfasst von:: Xinqiang Li, Ruixia Li, Xiaolong Miao, Xin Zhou, Bin Wu, Junning Cao, Chengyu Wang, Shipeng Li, Jinzhen Cai

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin