Pituitary adenomas (PAs) are benign tumors arising from the anterior pituitary, with an incidence of 3.9–7.4/100.000/year and a prevalence of 76–116/100.000/year [ 1 – 3 ]. A histological classification is based on pituitary hormone content as …
verfasst von:
Cristina Capatina, Felicia Alexandra Hanzu, José Miguel Hinojosa-Amaya, Maria Fleseriu
Omer Doron, Tamika Wong, Faina Ablyazova, Souvik Singha, Julianna Cavallaro, Netanel Ben-Shalom, Randy S. D’Amico, Manju Harshan, Amy McKeown, Avraham Zlochower, David J. Langer, John A. Boockvar
Primary tumors of the central nervous system (CNS) are amongst the most common neoplasms and are the leading cause of disease-related death in children [ 1 ]. The histologic and molecular makeup of these CNS neoplasms differs substantially from …
verfasst von:
Rebecca Ronsley, Kristine A. Karvonen, Bonnie Cole, Vera Paulson, Jeff Stevens, Erin E. Crotty, Jason Hauptman, Amy Lee, Shannon M. Stasi, Christina M. Lockwood, Sarah E. S. Leary
Radiotherapy, with or without surgery and chemotherapy, forms an integral part of the treatment paradigm for most malignant and many benign brain tumors [ 1 ]. The effects of treatment on the normal brain, including adverse radiation effects (ARE) …
verfasst von:
Victor Goulenko, Venkatesh Shankar Madhugiri, Amade Bregy, Matthew Recker, Lindsay Lipinski, Andrew Fabiano, Robert Fenstermaker, Robert Plunkett, Ajay Abad, Ahmed Belal, Ronald Alberico, Jingxin Qiu, Dheerendra Prasad
Neurofibromatosis type 1 (NF1) is a tumor predisposition syndrome genetically characterized by mutations in the NF1 tumor suppressor gene and clinically recognized through the development of multiple neurofibromas [ 1 ]. Much scientific progress …
verfasst von:
Archis R. Bhandarkar, Shaan Bhandarkar, Dusica Babovic-Vuksanovic, Aditya Raghunathan, Jonathan Schwartz, Robert J. Spinner
Breast cancer (BC) patients who develop brain metastases (BrM) experience diminished survival following diagnosis, and many experience a rapid decline in quality of life [ 1 ]. In a Surveillance, Epidemiology, and End Results (SEER) database …
verfasst von:
Christopher Poletes, Bardia Amanirad, Anna T. Santiago, Michael Yan, Tatiana Conrad, Katarzyna J. Jerzak, David B. Shultz
Meningiomas account for approximately 35% of primary brain tumors and are typically benign, indolent tumors originating from the arachnoid cells of the dura [ 1 ]. However, 6–8% of meningiomas are atypical or malignant, with recurrence rates of up …
verfasst von:
Michael M. Covell, Joanna M. Roy, Nithin Gupta, Ahmed Sami Raihane, Kranti C. Rumalla, Amanda Cyntia Lima Fonseca Rodrigues, Evan Courville, Christian A. Bowers
Gliomas are the most common primary intracranial tumors, accounting for more than 80% of malignant brain tumors. These tumors are highly diverse, and their prognosis varies widely: overall survival for patients with pilocytic astrocytoma can be …
verfasst von:
Malte Ottenhausen, Mirjam Renovanz, Isabell Bartz, Alicia Poplawski, Darius Kalasauskas, Harald Krenzlin, Naureen Keric, Florian Ringel
5-aminolevulinic acid (5-ALA) is a clinical fluorescence agent first introduced in neurosurgery as an adjuvant tool for malignant glioma resection in 1998 [ 41 ]. It is a natural precursor of hemoglobin in human cells that, when taken orally …
verfasst von:
Erasmo Barros da Silva Jr, Ricardo Ramina, Jorge Luis Novak Filho, Gustavo Simiano Jung, Giulia Xavier Bornancin, Maurício Coelho Neto
Gliomatosis cerebri (GC) is defined as a diffuse glioma that exhibits an infiltrative growth pattern affecting at least three lobes of the brain while grossly maintaining the underlying normal brain architecture [ 1 , 2 ]. Initially recognized as a …
verfasst von:
Ilah Shin, Yongsik Sim, Seo Hee Choi, Yae Won Park, Narae Lee, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee
Glioblastoma (GBM; World Health Organization (WHO) Grade IV) is the most common and aggressive primary brain tumour in adults, accounting for about 15% of all primary brain tumours and roughly 48% of all malignant gliomas [ 1 , 2 ]. Most cases of …
verfasst von:
Wafa Baqri, Kathryn Rzadki, Steven Habbous, Sunit Das
Neurooncology is a rapidly evolving field, with advances in surgical techniques, radiation therapy, and systemic therapy resulting in improved outcomes for patients with brain tumors. Despite these encouraging strides, the management of malignant …
verfasst von:
Anna Cecilia Lawson McLean, Aaron Lawson McLean, Thomas Ernst, Marie-Therese Forster, Christian Freyschlag, Jens Gempt, Roland Goldbrunner, Stefan Grau, Christine Jungk, Birgitt van Oorschot, Steffen K. Rosahl, Ulrich Wedding, Christian Senft, Marcel A. Kamp, on behalf of the German Consortium for Excellence in Neurooncology, Palliative Care (GCE-NPC)
Brain metastases develop in roughly 10–30% of adult cancer patients, and represent a major cause of morbidity and mortality [ 1 – 3 ]. Stereotactic radiosurgery (SRS) has emerged as the treatment of choice for patients with limited brain metastases …
verfasst von:
Mustafa M. Basree, Chengnan Li, Hyemin Um, Anthony H. Bui, Manlu Liu, Azam Ahmed, Pallavi Tiwari, Alan B. McMillan, Andrew M. Baschnagel
Glioblastoma (GBM), the most common malignant primary brain tumor, is uniformly fatal despite conventional therapy with surgery, radiation, and chemotherapy. One of the difficulties in treating GBM stems from the intrinsic privileged nature of the …
verfasst von:
Omer Doron, Tamika Wong, Faina Ablyazova, Souvik Singha, Julianna Cavallaro, Netanel Ben-Shalom, Randy S. D’Amico, Manju Harshan, Amy McKeown, Avraham Zlochower, David J. Langer, John A. Boockvar
Glioblastoma (GBM) is the most common adult central nervous system malignancy [ 1 ]. GBM has an overall poor prognosis, which is reduced further by advanced age, frailty, and incomplete extent of surgical resection [ 2 ]. The landmark Stupp et al.
verfasst von:
Megan Parker, Foad Kazemi, A. Karim Ahmed, Cathleen C. Kuo, Sumil K. Nair, Jordina Rincon-Torroella, Christopher Jackson, Gary Gallia, Chetan Bettegowda, Jon Weingart, Henry Brem, Debraj Mukherjee
Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non-Hodgkin lymphoma that accounts for 3–5% of all primary intracranial tumors [ 1 , 2 ]. Whole-brain radiotherapy (WBRT) alone for PCNSL results in overall survival (OS) …
Intracranial meningiomas often recur even after gross total resection with and without adjuvant radiation treatment, with a rate ranging from 10 to 32% at 10 years [ 1 , 2 ]. The main risk factors include the WHO grade [ 3 – 5 ], the proliferation …
verfasst von:
Francesco Maiuri, Sergio Corvino, Giuseppe Corazzelli, Marialaura Del Basso De Caro
