Immunologic Research OnlineFirst articles

Open Access 31.05.2024 | Review

Highlighting the role of CD44 in cervical cancer progression: immunotherapy’s potential in inhibiting metastasis and chemoresistance

Cervical cancer affects thousands of women globally with recurring high-risk HPV infections being at the centre of cervical pathology. Oncological treatment strategies are continually challenged by both chemoresistance and metastasis within …

verfasst von:: Cayleigh de Sousa, Carla Eksteen, Johann Riedemann, Anna-Mart Engelbrecht

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30.05.2024 | Research

CCR2+TREM-1+ monocytes promote natural killer T cell dysfunction contributing towards HBV disease progression

Natural killer T (NKT) cells are amongst the most important innate immune cells against hepatitis B virus (HBV) infection. Moreover, previous studies have shown that HBV infection induced TREM-1+ expression in monocyte and secretion of …

verfasst von:: Xiaojuan Wu, Wenling Zhao, Qiang Miao, Shiya Shi, Bin Wei, Limei Luo, Bei Cai

Open Access 29.05.2024 | Research

Assessment of NLRP3 inflammasome activation in patients with chronic obstructive pulmonary disease before and after lung transplantation

The interplay between purinergic receptors as well as pattern recognition receptors like Toll-like receptors (TLRs) and NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) might have a role in the pathogenesis of chronic obstructive …

verfasst von:: Lada Rumora, Ivona Markelić, Iva Hlapčić, Andrea Hulina Tomašković, Marija Fabijanec, Feđa Džubur, Miroslav Samaržija, Andrea Vukić Dugac

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Open Access 29.05.2024 | Research

Gender disparities in Behçet’s syndrome: identifying distinct phenotypes through cluster analysis

Behçet’s syndrome (BS) is a complex, multi-systemic disorder with a global occurrence, notably concentrated along the Silk Road. This study aimed to investigate gender-specific expressions and clinical phenotypes in BS patients within the Eastern …

verfasst von:: Gamze Kılıç, Kemal Faruk Körüklü, Muhammed Galip Kumcu, Elif Çakır, Murat Karkucak, Erkan Kılıç

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23.05.2024 | Research

Inflammasome functional activities in B lymphocytes

Studies in animal models and human subjects have shown that, in addition to their implication in innate immunity, inflammasomes also can play a role in adaptive immunity. However, the contribution of the nucleotide-binding oligomerization domain- …

verfasst von:: Man Lun Hsu, Kai Fu Jhuang, Moncef Zouali

21.05.2024 | Review

The IL-12 family of heterodimeric cytokines in polycystic ovarian syndrome: biological role in induction, regulation, and treatment

Polycystic ovary syndrome (PCOS) is a diverse endocrine disorder widely recognized as the prevailing metabolic condition among women in their reproductive years. The precise pathophysiological mechanisms underlying PCOS remain incompletely …

verfasst von:: Mingyan Zheng, Feng Zhao

21.05.2024 | RESEARCH

The role of tumor-associated macrophages in the radioresistance of esophageal cancer cells via regulation of the VEGF-mediated angiogenic pathway

Tumor-associated macrophages (TAMs) are known to promote tumor growth, invasion, metastasis, and protumor angiogenesis, but the role of TAMs in evading radiotherapy in esophagus cancer remains unclear. In this study, we first induced TAMs from …

verfasst von:: Fei Sun, Yingying Lian, Mengyun Zhou, Judong Luo, Lijun Hu, Jianlin Wang, Zhiqiang Sun, Jingping Yu

21.05.2024 | RESEARCH

Lupus progression deteriorates oogenesis quality in MRL/lpr mice

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of the immune response against self antigens. Numerous reproductive complications, including reduced birth rate and complications for the mother and the …

verfasst von:: Stefka Delimitreva, Gabriela Boneva, Irina Chakarova, Valentina Hadzhinesheva, Ralitsa Zhivkova, Maya Markova, Venera Nikolova, Anton Kolarov, Nikola Mladenov, Silviya Bradyanova, József Prechl, Nikolina Mihaylova, Andrey Tchorbanov

16.05.2024 | RESEARCH

Prognostic model incorporating immune checkpoint genes to predict the immunotherapy efficacy for lung adenocarcinoma: a cohort study integrating machine learning algorithms

This study aimed to develop and validate a nomogram based on immune checkpoint genes (ICGs) for predicting prognosis and immune checkpoint blockade (ICB) efficacy in lung adenocarcinoma (LUAD) patients. A total of 385 LUAD patients from the TCGA …

verfasst von:: Xi-Lin Yang, Zheng Zeng, Chen Wang, Guang-Yu Wang, Fu-Quan Zhang

15.05.2024 | Research

Inhibition of cIAP1/2 reduces RIPK1 phosphorylation in pulmonary endothelial cells and alleviate sepsis-induced lung injury and inflammatory response

Acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) is a severe complication of sepsis characterized by acute respiratory distress, hypoxemia, and diffuse bilateral pulmonary infiltrates. The regulation of RIPK1 is an important part …

verfasst von:: Xiaoyu Liu, Yan Li, Weijian Zhang, Nan Gao, Jie Chen, Cheng Xiao, Guoqiang Zhang

Open Access 15.05.2024 | RESEARCH

Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses — a randomized, placebo-controlled clinical trial

The gut microbiome can modulate systemic inflammation and is therefore target for immunomodulation. Immunomodulating effects of EDP1815, a bacterial commensal strain of Prevotella histicola, were studied in healthy participants. Effects on …

verfasst von:: Boukje C. Eveleens Maarse, Micha N. Ronner, Manon A. A. Jansen, Tessa Niemeyer-van der Kolk, Aliede E. in ’t Veld, Erica S. Klaassen, Saira Ahmad, Andrea Itano, Duncan McHale, Matthijs Moerland

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09.05.2024 | Research

Inhibition of LSD1 via SP2509 attenuated the progression of rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia, pannus formation, and cartilage and bone destruction. Lysine-specific demethylase 1 (LSD1), an enzyme involved in transcriptional regulation, has an …

verfasst von:: Ziliang Yu, Peipei Li, Dagong Gao, Yalong Hu, Fei Xia, Lei Liu, Jian Liu, Wei Liu, Haiping Zhang

Open Access 07.05.2024 | ORIGINAL ARTICLE

Genetic variability of three common NK and γδ T cell receptor genes (FCγ3R, NCR3, and DNAM-1) and their role in Polish patients with rheumatoid arthritis and ankylosing spondylitis

Various lymphocyte subpopulations, including NK cells as well as γδ T cells, have been considered an important element in the pathogenesis of autoimmune, inflammatory, rheumatic diseases, such as rheumatoid arthritis (RA) and ankylosing …

verfasst von:: Sylwia Biały, Milena Iwaszko, Jerzy Świerkot, Katarzyna Kolossa, Joanna Wielińska, Sławomir Jeka, Katarzyna Bogunia-Kubik

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02.05.2024 | RESEARCH

DAP1-2: a synthetic peptide targeting IL-1R1 receptor effectively suppresses IL-1β in vitro

The pathological manifestation of the inflammatory process primarily stems from the heightened release of pro-inflammatory cytokines, with IL-1β standing out as a pivotal cytokine. The excessive presence of IL-1β disrupts immune signaling, thereby …

verfasst von:: Ellen De-Pieri, Rubya Pereira Zaccaron, Camille Generoso Mezzari, Mariana de Melo Cardoso, Laura De Roch Casagrande, Paulo Cesar Lock Silveira, Ricardo Andrez Machado-de-Ávila

01.05.2024 | RESEARCH

SIT1 identifies circulating hypoactive T cells with elevated cytotoxic molecule secretion in systemic lupus erythematosus patients

This study aims to elucidate the expression and functionality of SIT1 in circulating CD8/CD4 + T cells in humans and to delineate its significance in systemic lupus erythematosus (SLE) patients. We employed multiparametric flow cytometry to …

verfasst von:: Ainizati Hasimu, Ayibaota Bahabayi, Ziqi Xiong, Qi Li, Zhonghui Zhang, Xingyue Zeng, Mohan Zheng, Zihang Yuan, Chen Liu

01.05.2024 | REVIEW

The immunosuppressive landscape in tumor microenvironment

Recent advances in cancer immunotherapy, especially immune checkpoint inhibitors (ICIs), have revolutionized the clinical outcome of many cancer patients. Despite the fact that impressive progress has been made in recent decades, the response rate …

verfasst von:: Wuyi Liu, Huyue Zhou, Wenjing Lai, Changpeng Hu, Rufu Xu, Peng Gu, Menglin Luo, Rong Zhang, Guobing Li

30.04.2024 | RESEARCH

FOXP4-AS1 promotes CD8+ T cell exhaustion and esophageal cancer immune escape through USP10-stabilized PD-L1

Esophageal cancer (EC) is the 9 th most frequently diagnosed cancer globally with more than 500,000 cancer death each year [ 1 ]. The incidence of EC varies greatly by area, and more than 50% of global cases occur in China [ 2 , 3 ]. EC is composed …

verfasst von:: Guo-yi Shen, Yi Zhang, Rong-zhi Huang, Zhi-yong Huang, Le-yi Yang, Ding-zhu Chen, Shao-bin Yang

27.04.2024 | RESEARCH

Desflurane alleviates LPS-induced acute lung injury by modulating let-7b-5p/HOXA9 axis

Acute lung injury (ALI) is characterized by acute respiratory failure with tachypnea and widespread alveolar infiltrates, badly affecting patients’ health. Desflurane (Des) is effective against lung injury. However, its mechanism in ALI remains …

verfasst von:: Xiaoyun Shi, Yundie Li, Shibiao Chen, Huaping Xu, Xiuhong Wang

Open Access 22.04.2024 | RESEARCH

Primary immune regulatory disorders (PIRD): expanding the mutation spectrum in Turkey and identification of sixteen novel variants

Human Inborn Errors of Immunity (IEIs) encompass a clinically and genetically heterogeneous group of disorders, ranging from mild cases to severe, life-threatening types. Among these, Primary Immune Regulatory Disorders (PIRDs) constitute a subset …

verfasst von:: Ayca Aykut, Asude Durmaz, Neslihan Karaca, Nesrin Gulez, Ferah Genel, Fatih Celmeli, M. Tuba Cogurlu, Mediha Akcan, Dilek Cicek, Funda Erol Cipe, Ayca Kiykim, Alisan Yıldıran, Kursad Unluhizarci, Sara Sebnem Kilic, Guzide Aksu, Omur Ardeniz, Necil Kutukculer

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17.04.2024 | RESEARCH

β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway

Massive evidence shows that intestinal tryptophan metabolites affected by intestinal flora can modulate the progression of rheumatoid arthritis (RA). However, the effects and mechanisms of intestinal tryptophan metabolites on RA are not yet …

verfasst von:: Xiaoran Su, Xinliu Wang, Xin Zhang, Yajie Sun, Yugai Jia

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