One third of patients with epilepsy will continue to have uncontrolled seizures despite treatment with antiseizure medications (ASMs). There is therefore a need to develop novel ASMs. Brivaracetam (BRV) is an ASM that was developed in a major drug …
This article was co-authored by Mr. Carsten Finke, a patient diagnosed with BRAF V600E metastatic melanoma, and his treating oncologist, Dr. med. Peter Mohr, Head of the Skin Cancer Unit at the Clinic of Dermatology and Oncology in Buxtehude …
Vitiligo is a chronic immune-mediated skin depigmentation disease characterized by chalky-white patches on the skin [ 1 ]. Depigmentation is attributed to melanocyte destruction by CD8 + T cells resulting from an interplay of genetic …
Gaucher disease (GD) is a rare lysosomal storage disorder caused by biallelic mutations in the acid β-glucosidase ( GBA1 ) gene, which lead to reduced acid β-glucosidase activity with consequent accumulation of its primary substrate …
verfasst von:
Raphael Schiffmann, Eugen Mengel, Mary Wallace, Camille Rochmann, James Turnbull, Robert Krupnick, Chad Gwaltney, Ruth Pulikottil-Jacob, Isabela Batsu, Riliang Zheng, Alaa Hamed
Asthma is a complex, heterogeneous disease of the airways involving multiple inflammatory pathways [ 1 ]. Most patients with asthma have mild-to-moderate disease, which can be managed with a combination of inhaled corticosteroids (ICS) and …
verfasst von:
Tara F. Carr, Wendy C. Moore, Monica Kraft, Guy Brusselle, Mario Castro, Geoffrey L. Chupp, Michael E. Wechsler, Gillian Hunter, Andrew W. Lindsley, Jean-Pierre Llanos, Luke K. Burke, Shradha Chandarana, Christopher S. Ambrose
Chronic pain is a leading cause of reduced quality of life in the USA [ 1 ]. Knee pain is especially prevalent, with 32% of men and 58% of women reporting experiencing it [ 2 ]. Numerous noninvasive and nonpharmacological treatments are available …
verfasst von:
Alaa Abd-Elsayed, Andrew Y. Matta, James N. Nitz, Lukas J. Henjum, Barnabas T. Shiferaw, Raven May, Kenneth J. Fiala
Atrial fibrillation (AF), the most prevalent disorder of heart rhythm [ 1 ], is characterized by uncoordinated atrial activation with subsequent loss of atrial mechanical function [ 2 ]. Nonvalvular AF (NVAF), defined as AF that occurs in the …
verfasst von:
Wael A. Almahmeed, Ahmad Hersi, Natasha Khalife, Mohamed Fathy Soliman Gamaleldin, Sid Ahmed Kherraf, Mohamed A. Sobhy, Renato D. Lopes, Maurice Khoury
Dédée F. Murrell, Pascal Joly, Victoria P. Werth, Hideyuki Ujiie, Margitta Worm, Aaron R. Mangold, Elena Avetisova, Jennifer Maloney, Elizabeth Laws, Eric Mortensen, Ariane Dubost-Brama, Arsalan Shabbir
Vasomotor symptoms (VMS), which are caused by an imbalance of hypothalamic thermoregulation, are commonly referred to as hot flashes and/or night sweats [ 1 – 3 ]. VMS episodes are the characteristic symptoms of menopausal transition; they affect …
verfasst von:
Antonia Morga, Lisa Zimmermann, Udaya Valluri, Emad Siddiqui, Lori McLeod, Randall H. Bender
Cardiovascular diseases (CVD) have exhibited a decline in their mortality rates over the past two decades; nonetheless, hypertension continues to be the predominant chronic disorder in the elderly population [ 1 , 2 ]. The incidence of CVD is …
verfasst von:
Jae Hoon Kim, Ji Hye Song, MinYoung Kim, Jang Hee Hong, Jung Sunwoo, Jin-Gyu Jung
Health state utility values provide a quantitative indication of the extent to which a particular disease, complication or treatment-related side effect influences the quality of life (QoL) of an individual. Utility values quantify QoL on a scale …
verfasst von:
William J. Valentine, Kirsi Norrbacka, Kristina S. Boye
Empagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that was initially developed for the improvement of glycemic control in patients with type 2 diabetes (T2D). Following further evaluation of empagliflozin in patients with T2D …
verfasst von:
Christoph Wanner, Hristo Iliev, Nathalia Duarte, Elke Schueler, Ana Rita Soares, Vikram Thanam, Egon Pfarr
The management of hemophilia has seen significant progress in recent years with the introduction of several novel pharmacological treatments, including extended half-life recombinant factors, non-factor therapy and the production of endogenous …
verfasst von:
Ester Zapotocka, Angelika Batorova, Ernest Bilic, Ana Boban, Carmen Escuriola Ettingshausen, Barbara Faganel Kotnik, Radomira Hrdlickova, Pawel Laguna, Jan Máchal, Laszlo Nemes, Irena Preloznik Zupan, Gediminas Puras, Marianna Zombori
The tibial nerve is an established target for neuromodulation in the management of overactive bladder (OAB) and its associated symptoms, including urge urinary incontinence (UUI). Technologies are currently available to deliver tibial nerve …
verfasst von:
Una J. Lee, Scott MacDiarmid, Catherine A. Matthews, Emily Gillespie, Kenneth M. Peters
Achondroplasia is a lifelong condition requiring lifelong management. There is consensus that infants and children with achondroplasia should be managed by a multidisciplinary team experienced in the condition. However, many people are lost to …
verfasst von:
Svein Fredwall, Moeenaldeen AlSayed, Tawfeg Ben-Omran, Silvio Boero, Valérie Cormier-Daire, Brigitte Fauroux, Encarna Guillén-Navarro, Florian Innig, Philip Kunkel, Christian Lampe, Mohamad Maghnie, Klaus Mohnike, Geert Mortier, Zagorka Pejin, Marco Sessa, Sérgio B. Sousa, Melita Irving
Although aspirin is deeply rooted in the most ancient history of medicine, the mechanism of action of this drug was only identified a few decades ago. Aspirin has several indications ranging from its long-known analgesic and antipyretic properties …
Over the past three decades, improvements in the quality of healthcare have led to an increase in life expectancy. In 2019, there were about 703 million people aged 65 years and over worldwide, and the number is expected to reach 1.5 billion by …
verfasst von:
Yali Chen, Yi Teng, Xiran Peng, Tao Zhu, Juan Liu, Mengchan Ou, Xuechao Hao
Patients with hematological malignancies are particularly susceptible to infections and commonly experience febrile neutropenia (FN) during chemotherapy [ 1 – 3 ]. Since the associated pathogens and the infectious foci are usually unclear during …
In 2023, several landmark trials with the potential to change clinical practice were presented at major international meetings including the American College of Cardiology (ACC), European Association for Percutaneous Cardiovascular Interventions …
verfasst von:
Patrick Savage, Brian Cox, Michael Shahmohammadi, Bronagh Kelly, Ian Menown
