Annals of Hematology OnlineFirst articles

01.06.2024 | Letter to the Editor

Effective management of heparin-resistant thrombosis: a case study on rivaroxaban therapy guided by thromboelastography

verfasst von:: Chuandong Hou, Bing Zhai, Bo Yang, Lijuan Zhang, Yuru Li, XueChun Lu

Open Access 30.05.2024 | Review

Chromothripsis in myeloid malignancies

Chromothripsis refers to massive genomic rearrangements developed during a catastrophic event. In total acute myeloid leukemia (AML), the incidence of chromothripsis ranges from 0 to 6.6%, in cases of complex karyotype AML, the incidence of …

verfasst von:: Chien-Yuan Chen

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30.05.2024 | Research

Immunophenotypic classification regarding prognosis in peripheral T cell lymphoma, NOS, and nodal T follicular helper T cell lymphoma, angioimmunoblastic-type

This study aimed to determine the clinicopathological predictive factors of peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS), and nodal T-follicular helper cell lymphoma, angioimmunoblastic-type (nTFH, AI-type). In this …

verfasst von:: Soyeon Choi, Jae-Cheol Jo, Yoo Jin Lee, Seoung Wan Chae, Hee Jeong Cha

29.05.2024 | Research

BeEAM vs. BEAM: evaluating conditioning regimens for autologous stem cell transplantation in patients with relapsed or refractory DLBCL

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma (NHL), accounting for 30% of NHL cases [ 1 ]. Approximately 60–70% of DLBCL cases achieve 10-year disease-free survival with R-CHOP immunochemotherapy, while …

verfasst von:: Ruiqi Wang, Xinghe Shangguan, Zhenxing Zhu, Dan Cong, Yuansong Bai, Wenlong Zhang

29.05.2024 | Correspondence

Chemotherapy vs. “TKI + immunotherapy” in treatment of B-cell acute lymphoblastic leukemia harboring the RCSD1::ABL2 fusion gene

verfasst von:: Yan Li, Qin Zhang, Haigang Shao

29.05.2024 | Research

Reduced-toxicity conditioning regimen with low dose post-transplantation cyclophosphamide and low-dose anti-thymocyte globulin as graft-versus-host disease prophylaxis for haploidentical stem cell transplantation in older patients

Reduced-toxicity conditioning (RIC) regimens are used for allogeneic hematopoietic stem cell transplantation in older patients. However, successful outcomes are hindered by graft-versus-host disease (GVHD), treatment-related mortality, and …

verfasst von:: Peipei Ye, Mengjie Wu, Junjie Cao, Renzhi Pei, Jiaojiao Yuan, Haihui Zhuang, Ying Fang, Ying Lu

28.05.2024 | Original Article

Efficacy of chidamide maintenance therapy versus autologous stem cell transplantation versus observation as a post-remission choice in the survival of adult patients with peripheral T-cell lymphoma: Post hoc analysis of a prospective, multicenter, phase 2 study in China

In this prospective, multicenter, Phase 2 clinical trial (NCT02987244), patients with peripheral T-cell lymphomas (PTCLs) who had responded to first-line chemotherapy with cyclophosphamide, doxorubicin or epirubicin, vincristine or vindesine …

verfasst von:: Wei Wang, Wei Zhang, Li-ping Su, Li-hong Liu, Yu-huan Gao, Quan-shun Wang, Hang Su, Yu-qin Song, Hui-lai Zhang, Jing Shen, Hong-mei Jing, Shu-ye Wang, Xi-nan Cen, Hui Liu, Ai-chun Liu, Zeng-jun Li, Jian-min Luo, Jian-xia He, Jing-wen Wang, O. A. O’Connor, Dao-bin Zhou

Open Access 28.05.2024 | Case Report

Pediatric acute myeloid leukemia with t(8;21) and KIT mutation treatment with avapritinib post-stem cell transplantation: a report of four cases

Acute myeloid leukemia (AML) with t(8;21) (q22;q22), which forms RUNX1::RUNX1T1 fusion gene, is classified as a favorable-risk group. However, the presence of mutations in KIT exon 17 results in an adverse prognosis in this group. Avapritinib, a …

verfasst von:: Qingwei Wang, Yixin Hu, Li Gao, Senlin Zhang, Jun Lu, Bohan Li, Jie Li, Yanhua Yao, Shengqin Cheng, Peifang Xiao, Shaoyan Hu

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28.05.2024 | Research

Daratumumab-based regimens for patients with multiple myeloma plus extramedullary plasmacytomas or paraskeletal plasmacytomas: initial follow-up of an Italian multicenter observational clinical experience

Myeloma with extramedullary plasmacytomas not adjacent to bone (EMP) is associated with an extremely poor outcome compared with paraosseous plasmacytomas (PP) as current therapeutic approaches are unsatisfactory. The role of new molecules and in …

verfasst von:: Giuseppe Mele, Daniele Derudas, Concetta Conticello, Gregorio Barilà, Massimo Gentile, Stefano Rocco, Salvatore Palmieri, Giulia Palazzo, Candida Germano, Giovanni Reddiconto, Nicola Sgherza, Danilo De Novellis, Carlotta Galeone, Sara Agavni’ Castiglioni, Luca Deiana, Anna Pascarella, Enrica Antonia Martino, Ilaria Foggetti, Ilenia Blasi, Alessandro Spina, Nicola Di Renzo, Alessandro Maggi, Giuseppe Tarantini, Francesco Di Raimondo, Giorgina Specchia, Pellegrino Musto, Domenico Pastore

Open Access 24.05.2024 | Case Report

Blinatumomab-induced macrophage activating syndrome (MAS) in adult with B-cell acute lymphoblastic leukemia (B-ALL)

Blinatumomab as a single agent has demonstrated superiority over salvage chemotherapy in patients with relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL), with manageable safety and efficacy. Though known to have anticipated drug …

verfasst von:: Adam Braun, Salman Otoukesh, Jose Tinajero, Guido Marcucci, Ibrahim Aldoss

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23.05.2024 | Case Report

Acute myeloid leukemia with paraneoplastic pemphigus successfully treated with a personalized antileukemic and immunosuppressive strategy

Bullous pemphigoid (BP) is a rare blistering disease often considered a primary sign of a paraneoplastic syndrome. Retrospective studies have established its link with hematological malignancies, particularly lymphoproliferative disorders. Here …

verfasst von:: Francesca Romana Iovene, Enrico Santinelli, Daniele Armiento, Chiara Sarlo, Chiara Bancone, Lorena Silvestri, Sabrina Erculei, Maria Grazia Sanhust, Antonio Cristiano, Emiliano Fabiani, Mariadomenica Divona, Camilla Page, Giovanni Di Zenzo, Maria Cantonetti, Luigi Rigacci

Open Access 23.05.2024 | Research

Flow-cytometry Assessment of DNA content and Immunophenotyping of Immune-cells in Lymph-node-specimens as a Potential Diagnostic Signature of Aggressiveness in B-Non-Hodgkin Lymphomas

Flow-cytometry (FC) is a powerful tool that can assist in lymphoma diagnosis in lymph node (LN) specimens. Although lymphoma diagnosis and classification are mainly based on tumor cell characteristics, surrounding cells are less employed in this …

verfasst von:: David Azoulay, Tal Tapuchi, Ohad Ronen, Luiza Akria, Hector I. Cohen, Celia Surio, Svetlana Rodin Chepa, Elizabeth Eshel, Moran Zarfati, Galia Stemer, Netanel A. Horowitz

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Open Access 22.05.2024 | Research

A preliminary study of roxadustat in the treatment of aplastic anemia patients with inadequate erythroid responses

Some aplastic anemia(AA) patients only have partial hematological responses after immunosuppressive therapy. Failure to achieve complete normalization of blood counts, particularly hemoglobin, will reduce their quality of life. This open-label …

verfasst von:: Yimeng Shi, Yufei Zhao, Weiru Liang, Baohang Zhang, Rui Kang, Wenrui Yang, Xin Zhao, Fengkui Zhang

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21.05.2024 | Research

The effectiveness of the doxorubicin-etoposide-methylprednisolone regimen for adult HLH secondary to rheumatic disease

To investigate the efficacy of the doxorubicin-etoposide-methylprednisolone, DEP) regimen as an effective treatment for adult Hemophagocytic Lymphohistiocytosis secondary to rheumatic disease and analyze prognosis in these patients. Fifty-eight …

verfasst von:: Dongfei Yin, Jingshi Wang, Zhao Wang

Open Access 21.05.2024 | Research

Real-life use of ropeg-interferon α2b in polycythemia vera: patient selection and clinical outcomes

Ropeginterferon-alfa2b (ropegIFNα2b) is a long-acting IFN formulation with broad FDA/EMA approval as a therapy of polycythemia vera (PV) with no symptomatic splenomegaly. There is currently lack of information on the real-world patient selection …

verfasst von:: Francesca Palandri, F. Branzanti, M. Venturi, A. Dedola, G. Fontana, M. Loffredo, A. Patuelli, E. Ottaviani, M. Bersani, M. Reta, O. Addimanda, V. Vicennati, N. Vianelli, M. Cavo

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Open Access 20.05.2024 | Research

Haemoglobinopathies and other rare anemias in Spain: ten years of a nationwide registry (REHem-AR)

REHem-AR was created in 2013. The progressive implementation of neonatal screening for haemoglobinopathies in Spanish autonomous communities where the registry had not been implemented, as well as the addition of new centres during this period …

verfasst von:: José Manuel Marco Sánchez, Eduardo Jesús Bardón Cancho, David Benéitez, Salvador Payán-Pernía, Anna Collado Gimbert, Anna Ruiz-Llobet, José Antonio Salinas, Elena Sebastián, Bienvenida Argilés, Mar Bermúdez, María Ángeles Vázquez, María José Ortega, Montserrat López Rubio, Ainhoa Gondra, José Javier Uriz, Marta Morado, María Teresa Coll, Mónica López Duarte, María Baro, Áurea Cervera, Valle Recasens, Carmen García Blanes, María Pozo del Carcavilla, María Tallon, Ana González Espín, Filip Camil Olteanu Olteanu, Pablo González, María Mar del Mañú Pereira, Elena Cela

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Open Access 20.05.2024 | Review Article

Neurological involvement in hematopoietic stem cell transplantation-associated thrombotic microangiopathy

Transplantation-associated thrombotic microangiopathy (TA-TMA) is a well-recognized serious complication of hematopoietic stem cell transplantation (HSCT). The understanding of TA-TMA pathophysiology has expanded in recent years. Dysregulation of …

verfasst von:: Wanying Liu, Xiaojian Zhu, Yi Xiao

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18.05.2024 | Research

STK10 mutations block erythropoiesis in acquired pure red cell aplasia via impairing ribosome biogenesis

Acquired pure red cell aplasia (PRCA) is anemia associated with the absence of erythroblasts and is characterized by persistent and easy recurrence. However, the underlying mechanisms of acquired PRCA remain obscure, and the role of gene mutations …

verfasst von:: Jichun Yang, Xiaofeng Shi, Xinyao Liu, Xinrui Qiao, Xun Zhou, Hongmin Li, Yali Du, Miao Chen, Dongdong Fang, Bing Han, Zhangbiao Long

18.05.2024 | Research

Clinical characteristics and prognosis of patients with newly diagnosed primary central nervous system lymphoma: a multicentre retrospective analysis

Bruton’s tyrosine kinase inhibitors (BTKi) exhibit superior efficacy in relapsed/refractory primary central nervous system lymphoma (PCNSL), but few studies have evaluated patients with newly diagnosed PCNSL, and even fewer studies have evaluated …

verfasst von:: Si-Jun Bai, Jian-Xia He, Yuan-Jun Zheng, Ye Geng, Yi-Nan Gao, Cai-Xia Zhang, Ya-Ru Wang, Li-Yuan Qin, Wen-Jun Wang, Lin-Hua Yang

17.05.2024 | Original Article

Impact of cladribine, cytarabine, and G-CSF (CLAG) as a bridging therapy prior to allogeneic hematopoietic stem cell transplantation in relapsed or refractory acute myeloid leukemia

The combination of cladribine, cytarabine, and G-CSF (CLAG) has exhibited robust synergistic anti-leukemia activity as an induction therapy (IT) in acute myeloid leukemia (AML). However, the impact of CLAG as a bridging therapy (BT) administered …

verfasst von:: Tong Cui, Huiyu Li, Shiyuan Zhou, Jing Li, Qian Zhu, Wenjuan Zhu, Zaixiang Tang, Xiao Ma, Huiying Qiu, Depei Wu, Xiaojin Wu

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