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Journal of Bone and Mineral Metabolism
Erschienen in: Journal of Bone and Mineral Metabolism 2/2023

13.03.2023 | Review Article

Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis

verfasst von: Rui-Xin Zhou, Yuan-Wei Zhang, Mu-Min Cao, Cun-Hao Liu, Yun-Feng Rui, Ying-Juan Li

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 2/2023

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Abstract

Osteoporosis (OP) is the most prevalent metabolic bone disease, characterized by the low bone mass and microarchitectural deterioration of bone tissue. Glucocorticoid (GC) clinically acts as one of the anti-inflammatory, immune-modulating, and therapeutic drugs, whereas the long-term use of GC may cause rapid bone resorption, followed by prolonged and profound suppression of bone formation, resulting in the GC-induced OP (GIOP). GIOP ranks the first among secondary OP and is a pivotal risk for fracture, as well as high disability rate and mortality, at both societal and personal levels, vital costs. Gut microbiota (GM), known as the “second gene pool” of human body, is highly correlated with maintaining the bone mass and bone quality, and the relation between GM and bone metabolism has gradually become a research hotspot. Herein, combined with recent studies and based on the cross-linking relationship between GM and OP, this review is aimed to discuss the potential mechanisms of GM and its metabolites on the OP, as well as the moderating effects of GC on GM, thereby providing an emerging thought for prevention and treatment of GIOP.
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Metadaten
Titel
Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis
verfasst von
Rui-Xin Zhou
Yuan-Wei Zhang
Mu-Min Cao
Cun-Hao Liu
Yun-Feng Rui
Ying-Juan Li
Publikationsdatum
13.03.2023
Verlag
Springer Nature Singapore
Erschienen in
Journal of Bone and Mineral Metabolism / Ausgabe 2/2023
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI
https://doi.org/10.1007/s00774-023-01415-0

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