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Endocrine

Erschienen in:

21.06.2023 | Original Article

Low total osteocalcin levels are associated with the risk of cardiovascular events among women with hyperglycaemia: a 7.6-year prospective study

verfasst von: Tingting Hu, Yun Shen, Yiting Xu, Yufei Wang, Yuqian Bao, Xiaojing Ma

Erschienen in: Endocrine | Ausgabe 1/2023

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Abstract

Purpose

To investigate the association between circulating osteocalcin and incident cardiovascular diseases in a community-based cohort, and further assess whether the association differs by different glycemic stages.

Methods

This cohort study included 1428 participants (626 men and 802 women) aged 50–80 years, without baseline cardiovascular diseases, and with osteocalcin data available. Circulating total osteocalcin levels were measured by electrochemiluminescence immunoassay. Multivariate Cox proportional hazards models were used to assess the relationship between osteocalcin levels and different glycemic stages with cardiovascular events.

Results

At baseline, 437 participants were normoglycaemia and 991 participants were hyperglycaemia. Median circulating osteocalcin levels were 16.43 (13.34–20.19) and 21.66 (17.95–26.11) ng/mL in men and women, respectively. During a mean follow-up of 7.6 years, 144 cases of cardiovascular diseases occurred (10.1%). The risk of incident cardiovascular diseases linearly increased with a decrease in baseline osteocalcin quartiles (quartile 1 versus quartile 4: hazard ratio 2.44, 95% confidence interval 1.07–5.55) in women, while not in men (P_{interaction on sex} = 0.028). Subgroup analyses showed that the association was more predominant in participants with baseline hyperglycaemia. Besides, the joint effect of baseline decreased osteocalcin levels and hyperglycaemia resulted in higher risks of future cardiovascular diseases.

Conclusions

Low baseline osteocalcin levels were associated with high risks of cardiovascular diseases in middle-aged and elderly women, which were more predominant among those with baseline hyperglycaemia.

Nur mit Berechtigung zugänglich

G. Hu, Gender difference in all-cause and cardiovascular mortality related to hyperglycaemia and newly-diagnosed diabetes. Diabetologia. 46(5), 608–617 (2003)CrossRefPubMed

X. Cai, Y. Zhang, M. Li, J.H. Wu, L. Mai, J. Li, Y. Yang, Y. Hu, Y. Huang, Association between prediabetes and risk of all-cause mortality and cardiovascular disease: updated meta-analysis. BMJ. 370, m2297 (2020)CrossRefPubMedPubMedCentral

T. Wang, J. Lu, Q. Su, Y. Chen, Y. Bi, Y. Mu, L. Chen, R. Hu, X. Tang, X. Yu, M. Li, M. Xu, Y. Xu, Z. Zhao, L. Yan, G. Qin, Q. Wan, G. Chen, M. Dai, D. Zhang, Z. Gao, G. Wang, F. Shen, Z. Luo, Y. Qin, L. Chen, Y. Huo, Q. Li, Z. Ye, Y. Zhang, C. Liu, Y. Wang, S. Wu, T. Yang, H. Deng, D. Li, S. Lai, Z.T. Bloomgarden, L. Shi, G. Ning, J. Zhao, W. Wang, 4C Study Group: ideal cardiovascular health metrics and major cardiovascular events in patients with prediabetes and diabetes. JAMA. Cardiol. 4(9), 874–883 (2019)CrossRefPubMedPubMedCentral

G. Liu, Y. Li, Y. Hu, G. Zong, S. Li, E.B. Rimm, F.B. Hu, J.E. Manson, K.M. Rexrode, H.J. Shin, Q. Sun, Influence of lifestyle on incident cardiovascular disease and mortality in patients with diabetes mellitus. J. Am. Coll. Cardiol. 71(25), 2867–2876 (2018)CrossRefPubMedPubMedCentral

Y. Takashi, D. Kawanami, The role of bone-derived hormones in glucose metabolism, diabetic kidney disease, and cardiovascular disorders. Int. J. Mol. Sci. 23(4), 2367 (2022)CrossRef

M. Zhou, X. Ma, H. Li, X. Pan, J. Tang, Y. Gao, X. Hou, H. Lu, Y. Bao, W. Jia, Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals. Eur. J. Endocrinol. 161(5), 723–729 (2009)CrossRefPubMed

J. Liu, Y. Wei, P. Zang, W. Wang, Z. Feng, Y. Yuan, H. Zhou, Z. Zhang, H. Lei, X. Yang, J. Liu, B. Lu, J. Shao, Circulating osteocalcin is associated with time in range and other metrics assessed by continuous glucose monitoring in type 2 diabetes. Diabetol. Metab. Syndr. 14(1), 109 (2022)CrossRefPubMedPubMedCentral

I. Kanazawa, T. Yamaguchi, M. Yamamoto, M. Yamauchi, S. Kurioka, S. Yano, T. Sugimoto, Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 94(1), 45–49 (2009)CrossRefPubMed

J. Dou, H. Li, X. Ma, M. Zhang, Q. Fang, M. Nie, Y. Bao, W. Jia, Osteocalcin attenuates high fat diet-induced impairment of endothelium-dependent relaxation through Akt/eNOS-dependent pathway. Cardiovasc. Diabetol. 13, 74 (2014)CrossRefPubMedPubMedCentral

10.

Y. Shen, L. Chen, J. Zhou, C. Wang, F. Gao, W. Zhu, G. Hu, X. Ma, H. Xia, Y. Bao, Low total osteocalcin levels are associated with all-cause and cardiovascular mortality among patients with type 2 diabetes: a real-world study. Cardiovasc. Diabetol. 21(1), 98 (2022)CrossRefPubMedPubMedCentral

11.

X. Zhang, Y. Shen, Y. Xu, Q. Xiong, Z. Lu, X. Ma, Y. Bao, W. Jia, Association of serum osteocalcin levels with major adverse cardiovascular events: a 4.4-year retrospective cohort study. Clin. Exp. Pharmacol. Physiol. 45(1), 3–9 (2018)CrossRefPubMed

12.

B.B. Yeap, S.A. Chubb, L. Flicker, K.A. McCaul, P.R. Ebeling, G.J. Hankey, J.P. Beilby, P.E. Norman, Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. The Health In Men Study. Osteoporos. Int. 23(2), 599–606 (2012)CrossRefPubMed

13.

T. Yamashita, K. Okano, Y. Tsuruta, T. Akiba, K. Nitta, Serum osteocalcin levels are useful as a predictor of cardiovascular events in maintenance hemodialysis patients. Int. Urol. Nephrol. 45(1), 207–214 (2013)CrossRefPubMed

14.

K. Holvik, N.M. van Schoor, E.M. Eekhoff, M. den Heijer, D.J. Deeg, P. Lips, R. de Jongh, Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study. Eur. J. Endocrinol. 171(2), 161–170 (2014)CrossRefPubMed

15.

T. Hu, Y. Shen, W. Cao, Y. Xu, Y. Wang, Y. Bao, X. Ma, The association and joint effect of adipocyte fatty acid-binding protein and obesity phenotype with cardiovascular events. J. Clin. Endocrinol. Metab. dgad110 (2023). Epub ahead of print

16.

G. Yang, L. Fan, J. Tan, G. Qi, Y. Zhang, J.M. Samet, C.E. Taylor, K. Becker, J. Xu, Smoking in China: findings of the 1996 National Prevalence Survey. JAMA. 282(13), 1247–1253 (1999)CrossRefPubMed

17.

V.D. Tran, V.V. Do, N.M. Pham, C.T. Nguyen, N.T. Xuong, J. Jancey, A.H. Lee, Validity of the International Physical Activity Questionnaire-Short Form for Application in Asian Countries: a study in Vietnam. Eval. Health. Prof. 43(2), 105–109 (2020)CrossRefPubMed

18.

T. Wang, J. Lu, L. Shi, G. Chen, M. Xu, Y. Xu, Q. Su, Y. Mu, L. Chen, R. Hu, X. Tang, X. Yu, M. Li, Z. Zhao, Y. Chen, L. Yan, G. Qin, Q. Wan, M. Dai, D. Zhang, Z. Gao, G. Wang, F. Shen, Z. Luo, Y. Qin, L. Chen, Y. Huo, Q. Li, Z. Ye, Y. Zhang, C. Liu, Y. Wang, S. Wu, T. Yang, H. Deng, J. Zhao, S. Lai, Y. Bi, R.A. DeFronzo, W. Wang, G. Ning; China Cardiometabolic Disease and Cancer Cohort Study Group, Association of insulin resistance and β-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study. Lancet. Diabetes. Endocrinol. 8(2), 115–124 (2020)CrossRefPubMed

19.

D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, R.C. Turner, Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28(7), 412–419 (1985)CrossRefPubMed

20.

A.S. Levey, L.A. Stevens, C.H. Schmid, Y.L. Zhang, A.F. Castro III, H.I. Feldman, J.W. Kusek, P. Eggers, F. Van Lente, T. Greene, J. Coresh; CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration), A new equation to estimate glomerular filtration rate. Ann. Intern. Med. 150(9), 604–612 (2009)CrossRefPubMedPubMedCentral

21.

T. Hu, Y. Shen, W. Cao, Y. Xu, Y. Wang, X. Ma, Y. Bao, Neck circumference for predicting the occurrence of future cardiovascular events: a 7.6-year longitudinal study. Nutr. Metab. Cardiovasc. Dis. 32(12), 2830–2838 (2022)CrossRefPubMed

22.

N.A. ElSayed, G. Aleppo, V.R. Aroda, R.R. Bannuru, F.M. Brown, D. Bruemmer, B.S. Collins, M.E. Hilliard, D. Isaacs, E.L. Johnson, S. Kahan, K. Khunti, J. Leon, S.K. Lyons, M.L. Perry, P. Prahalad, R.E. Pratley, J.J. Seley, R.C. Stanton, R.A. Gabbay; on behalf of the American Diabetes Association, 2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023. Diabetes. Care. 46(Suppl 1), S19–S40 (2023)

23.

T. Unger, C. Borghi, F. Charchar, N.A. Khan, N.R. Poulter, D. Prabhakaran, A. Ramirez, M. Schlaich, G.S. Stergiou, M. Tomaszewski, R.D. Wainford, B. Williams, A.E. Schutte, 2020 International Society of Hypertension Global Hypertension Practice Guidelines. J. Hypertens. 75(6), 1334–1357 (2020)CrossRef

24.

Joint Committee for Guideline Revision, 2016 Chinese guidelines for the management of dyslipidemia in adults. J. Geriatr. Cardiol. 15(1), 1–29 (2018)PubMedCentral

25.

Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World. Health. Organ. Tech. Rep. Ser. 894, i–253 (2000).

26.

Y.C. Hwang, M. Kang, I.J. Cho, I.K. Jeong, K.J. Ahn, H.Y. Chung, M.K. Lee, Association between the circulating total osteocalcin level and the development of cardiovascular disease in middle-aged men: a mean 8.7-year longitudinal follow-up study. J. Atheroscler. Thromb. 22(2), 136–143 (2015)CrossRefPubMed

27.

B.B. Yeap, H. Alfonso, S.A. Chubb, E. Byrnes, J.P. Beilby, P.R. Ebeling, C.A. Allan, C. Schultz, G.J. Hankey, J. Golledge, L. Flicker, P.E. Norman, Proportion of undercarboxylated osteocalcin and serum P1NP predict incidence of myocardial infarction in older men. J. Clin. Endocrinol. Metab. 100(10), 3934–3942 (2015)CrossRefPubMed

28.

Q. Gong, P. Zhang, J. Wang, J. Ma, Y. An, Y. Chen, B. Zhang, X. Feng, H. Li, X. Chen, Y.J. Cheng, E.W. Gregg, Y. Hu, P.H. Bennett, G. Li; Da Qing Diabetes Prevention Study Group, Morbidity and mortality after lifestyle intervention for people with impaired glucose tolerance: 30-year results of the Da Qing Diabetes Prevention Outcome Study. Lancet. Diabetes. Endocrinol. 7(6), 452–461 (2019)

29.

M. Ferron, J. Wei, T. Yoshizawa, A. Del Fattore, R.A. DePinho, A. Teti, P. Ducy, G. Karsenty, Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell. 142(2), 296–308 (2010)CrossRefPubMedPubMedCentral

30.

K. Fulzele, R.C. Riddle, D.J. DiGirolamo, X. Cao, C. Wan, D. Chen, M.C. Faugere, S. Aja, M.A. Hussain, J.C. Brüning, T.L. Clemens, Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell. 185(4), 746 (2022)CrossRefPubMedPubMedCentral

31.

J. Wei, M. Ferron, C.J. Clarke, Y.A. Hannun, H. Jiang, W.S. Blaner, G. Karsenty, Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J. Clin. Invest. 124(4), 1–13 (2014)CrossRefPubMed

Titel: Low total osteocalcin levels are associated with the risk of cardiovascular events among women with hyperglycaemia: a 7.6-year prospective study
verfasst von: Tingting Hu
Yun Shen
Yiting Xu
Yufei Wang
Yuqian Bao
Xiaojing Ma
Publikationsdatum: 21.06.2023
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 1/2023
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-023-03428-1

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Low total osteocalcin levels are associated with the risk of cardiovascular events among women with hyperglycaemia: a 7.6-year prospective study

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