Background
Patients and methods
Study population
Radiotherapy treatment and radiation doses evaluation
Transthoracic echocardiography
Statistical analysis
Results
Study population
Left-sided BC patients n = 64 | |
---|---|
Age in years, mean ± SD | 58 ± 9 |
Type of cancer, n (%) | |
In situ | 11 (17%) |
Invasive | 53 (83%) |
Surgery, n (%) | |
Breast conserving | 61 (95%) |
Mastectomy | 3 (54%) |
Regional lymph node irradiation | 22 (34%) |
Supraclavicular alone | 1 |
Internal mammary alone | 2 |
Both | 19 |
Body mass index in kg/m2, mean ± SD | 24.5 ± 4.2 |
Smoking, n (%) | |
Never-smokers | 34 (53%) |
Former smokers | 20 (31%) |
Current smokers | 10 (16%) |
Systolic blood pressure, in mmHg, mean ± SD | 119 ± 12 |
Diastolic blood pressure in mmHg, mean ± SD | 75 ± 10 |
Hypertension, n (%) | 14 (22%) |
Diabetes, n (%) | 5 (8%) |
Hypercholesterolemia, n (%) | 20 (31%) |
Cardiac doses in Gy | |
Whole Heart | |
Mean ± SD | 3.05 ± 1.31 |
Min – Max | 0.87–6.37 |
Left Ventricle | |
Mean ± SD | 6.68 ± 3.36 |
Min – Max | 1.16–13.42 |
Left Descending Artery | |
Mean ± SD | 16.41 ± 7.41 |
Min – Max | 1.68–34.63 |
Circumflex Artery | |
Mean ± SD | 1.65 ± 0.82 |
Min – Max | 0.53–4.34 |
Right Coronary Artery | |
Mean ± SD | 0.71 ± 0.37 |
Min – Max | 0.14–2.50 |
Multilayer evolution of the global longitudinal strain
Baseline n = 64 | 6 months after RT n = 64 | P-value | Relative change (%)p-value | |
---|---|---|---|---|
LVEF, % | 61 ± 7 | 60 ± 9 | 0.073 | Na. |
GLS, % | ||||
Endocardial layer | −20.0 ± 3.2 | −18.8 ± 3.8 | 0.02 | −4.7%; 0.05 |
Mid-myocardial layer | −16.0 ± 2.7 | −15.0 ± 3.1 | 0.02 | − 4.4%; 0.11 |
Epicardial layer | −12.3 ± 2.5 | −11.4 ± 2.8 | 0.02 | −4.2%; 0.25 |
Left ventricular regional evolution of the longitudinal strain in the endocardial layer
Low dose to the LV n = 42 | High dose to the LV n = 22 | ||||
---|---|---|---|---|---|
V0 | V6 | V0 | V6 | ||
Basal level, % | Mean ± SD | −16.7 ± 5.6 | −17.1 ± 5.0 | −19.0 ± 3.5 | −17.8 ± 3.2 |
p-value | 0.52 | 0.10 | |||
Mid-level, % | Mean ± SD | − 18.6 ± 3.0 | −17.0 ± 5.2 | −17.6 ± 3.4 | −17.5 ± 4.7 |
p-value | 0.06 | 0.90 | |||
Apical level, % | Mean ± SD | −26.7 ± 5.8 | −25.0 ± 7.2 | −25.5 ± 6.3 | −22.7 ± 6.9 |
p-value | 0.18 | 0.04a |
Coronary arteries territorial evolution of the endocardial layer longitudinal strain
Low dose to the LV N = 42 | High dose to the LV N = 22 | ||||
---|---|---|---|---|---|
V0 | V6 | V0 | V6 | ||
TLS - LAD, % | Mean ± SD | − 22.9 ± 4,3 | −21.8 ± 5,0 | − 22.7 ± 3.4 | −20.7 ± 4.5 |
p-value | 0.20 | 0.05a | |||
TLS - Cx, % | Mean ± SD | − 19.0 ± 4.9 | − 17.5 ± 5.1 | −19.5 ± 3.8 | −17.9 ± 5.5 |
p-value | 0.10 | 0.25 | |||
TLS - RCA, % | Mean ± SD | − 16.2 ± 4.7 | −16.2 ± 5.2 | −16.9 ± 4.8 | −15.6 ± 5.1 |
p-value | 0.97 | 0.35 |