Skip to main content
Erschienen in: Journal of Pediatric Neuropsychology 1/2023

01.03.2023 | Case Study

Neurodevelopmental Trajectory in a Child with Congenital Heart Disease

verfasst von: Hannah Greenbaum, Jacqueline H. Sanz, Mary T. Donofrio, Patrick Callahan

Erschienen in: Journal of Pediatric Neuropsychology | Ausgabe 1/2023

Einloggen, um Zugang zu erhalten

Abstract

Children with congenital heart disease are at high risk for neurodevelopmental challenges. There is little known, however, about possible effects of changing cardiac status on neurodevelopmental profiles over time. We examined the developmental trajectory of neuropsychological skills in a child with congenital heart disease who underwent multiple procedures over the course of childhood and adolescence. Serial neuropsychological evaluation (ages 8, 10, 11, and 14), was used to determine how cognitive skills varied as a result of changing cardiac status, and showed a stable pattern of strengths, including reasoning, learning and memory, with weaknesses in attention/executive skills, processing speed, and fine motor skills. There was a steady, downward trend in some areas, such as sustained attention and flexibility, suggesting a slower trajectory of development. In other areas, including aspects of executive function, processing speed, and verbal retrieval, there was fluctuation of scores with changing cardiac status that recovered following intervention. The clinical utility of serial neuropsychological evaluation in monitoring the effects of changing cardiac status is discussed.
Literatur
Zurück zum Zitat American Academy of Pediatrics. (2016). Pediatric clinical practice guidelines & policies, 16th edition: A compendium of evidence-based research for pediatric practice. American Academy of Pediatrics.CrossRef American Academy of Pediatrics. (2016). Pediatric clinical practice guidelines & policies, 16th edition: A compendium of evidence-based research for pediatric practice. American Academy of Pediatrics.CrossRef
Zurück zum Zitat Bellinger, D. C., Jonas, R. A., Rappaport, L. A., Wypij, D., Wernovsky, G., Kuban, K. C., & Strand, R. D. (1995). Developmental and neurologic status of children after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass. The New England Journal of Medicine, 332(9), 549–555. https://doi.org/10.1056/NEJM199503023320901CrossRefPubMed Bellinger, D. C., Jonas, R. A., Rappaport, L. A., Wypij, D., Wernovsky, G., Kuban, K. C., & Strand, R. D. (1995). Developmental and neurologic status of children after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass. The New England Journal of Medicine, 332(9), 549–555. https://​doi.​org/​10.​1056/​NEJM199503023320​901CrossRefPubMed
Zurück zum Zitat Bellinger, D. C., Wypij, D., Kuban, K. C. K., Rappaport, L. A., Hickey, P. R., Wernovsky, G., & Newburger, J. W. (1999). Developmental and neurological status of children at 4 years of age after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass. Circulation, 100(5), 526–532. https://doi.org/10.1161/01.CIR.100.5.526CrossRefPubMed Bellinger, D. C., Wypij, D., Kuban, K. C. K., Rappaport, L. A., Hickey, P. R., Wernovsky, G., & Newburger, J. W. (1999). Developmental and neurological status of children at 4 years of age after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass. Circulation, 100(5), 526–532. https://​doi.​org/​10.​1161/​01.​CIR.​100.​5.​526CrossRefPubMed
Zurück zum Zitat Calderon, J., Bonnet, D., Courtin, C., Concordet, S., Plumet, M.-H., & Angeard, N. (2010). Executive function and theory of mind in school-aged children after neonatal corrective cardiac surgery for transposition of the great arteries. Developmental Medicine and Child Neurology, 52(12), 1139–1144.CrossRefPubMed Calderon, J., Bonnet, D., Courtin, C., Concordet, S., Plumet, M.-H., & Angeard, N. (2010). Executive function and theory of mind in school-aged children after neonatal corrective cardiac surgery for transposition of the great arteries. Developmental Medicine and Child Neurology, 52(12), 1139–1144.CrossRefPubMed
Zurück zum Zitat Cassidy, A. R., White, M. T., DeMaso, D. R., Newburger, J. W., & Bellinger, D. C. (2016). Processing speed, executive function, and academic achievement in children with dextro-transposition of the great arteries: Testing a longitudinal developmental cascade model. Neuropsychology, 30(7), 874–885.CrossRefPubMedPubMedCentral Cassidy, A. R., White, M. T., DeMaso, D. R., Newburger, J. W., & Bellinger, D. C. (2016). Processing speed, executive function, and academic achievement in children with dextro-transposition of the great arteries: Testing a longitudinal developmental cascade model. Neuropsychology, 30(7), 874–885.CrossRefPubMedPubMedCentral
Zurück zum Zitat Cassidy, A. R., Ilardi, D., Bowen, S. R., et al. (2017a). Congenital heart disease: A primer for the pediatric neuropsychologist. Child Neuropsychology Journal on Normal and Abnormal Development in Childhood and Adolescence, 24, 1–44. Cassidy, A. R., Ilardi, D., Bowen, S. R., et al. (2017a). Congenital heart disease: A primer for the pediatric neuropsychologist. Child Neuropsychology Journal on Normal and Abnormal Development in Childhood and Adolescence, 24, 1–44.
Zurück zum Zitat Cassidy, A. R., Newburger, J. W., & Bellinger, D. C. (2017b). Learning and memory in adolescents with critical biventricular congenital heart disease. Journal of The International Neuropsychological Society, 23, 627–639.CrossRefPubMed Cassidy, A. R., Newburger, J. W., & Bellinger, D. C. (2017b). Learning and memory in adolescents with critical biventricular congenital heart disease. Journal of The International Neuropsychological Society, 23, 627–639.CrossRefPubMed
Zurück zum Zitat Friedman, T., Choen, O., Ziser, A., Kerner, A., Bitton-Worms, K., & Bolotin, G. (2017). Emboli and cognitive state in surgical vs. transcatheter aortic valve replacement. Asian Cardiovascular and Thoracic Annals, 25(6), 425–431.CrossRefPubMed Friedman, T., Choen, O., Ziser, A., Kerner, A., Bitton-Worms, K., & Bolotin, G. (2017). Emboli and cognitive state in surgical vs. transcatheter aortic valve replacement. Asian Cardiovascular and Thoracic Annals, 25(6), 425–431.CrossRefPubMed
Zurück zum Zitat Hoffman, G. M., Brosig, C. L., Bear, L. M., Tweddell, J. S., & Mussatto, K. A. (2016). Effect of intercurrent operation and cerebral oxygenation on developmental trajectory in congenital heart disease. Annals and Thoracic Surgery, 101(2), 708–716.CrossRef Hoffman, G. M., Brosig, C. L., Bear, L. M., Tweddell, J. S., & Mussatto, K. A. (2016). Effect of intercurrent operation and cerebral oxygenation on developmental trajectory in congenital heart disease. Annals and Thoracic Surgery, 101(2), 708–716.CrossRef
Zurück zum Zitat Hövels-Gürich, H. H., Bauer, S. B., Schnitker, R., Hinckeldey, K. W.-v., Messmer, B. J., Seghaye, M.-C., & Huber, W. (2008). Long-term outcome of speech and language in children after corrective surgery for cyanotic or acyanotic cardiac defects in infancy. European Journal of Paediatric Neurology, 12(5), 378–386. https://doi.org/10.1016/j.ejpn.2007.10.004CrossRefPubMed Hövels-Gürich, H. H., Bauer, S. B., Schnitker, R., Hinckeldey, K. W.-v., Messmer, B. J., Seghaye, M.-C., & Huber, W. (2008). Long-term outcome of speech and language in children after corrective surgery for cyanotic or acyanotic cardiac defects in infancy. European Journal of Paediatric Neurology, 12(5), 378–386. https://​doi.​org/​10.​1016/​j.​ejpn.​2007.​10.​004CrossRefPubMed
Zurück zum Zitat Marino, B., Likpkin, P. H., Newburger, J. W., Peacock, G., Gerdes, M., Gaynor, J. W., Mussatto, K. A., … Mahle, W. T. (2012). Neurodevelopmental outcomes in children with congenital heart disease: Evaluation and management: A scientific statement from the American heart association. Circulation, 126(3), 1143-1172. Marino, B., Likpkin, P. H., Newburger, J. W., Peacock, G., Gerdes, M., Gaynor, J. W., Mussatto, K. A., … Mahle, W. T. (2012). Neurodevelopmental outcomes in children with congenital heart disease: Evaluation and management: A scientific statement from the American heart association. Circulation, 126(3), 1143-1172.
Zurück zum Zitat Schaefer, C., von Rhein, M., Knirsch, W., Huber, R., Natalucci, G., Caflisch, J., Landolt, M. A., & Latal, B. (2013). Neurodevelopmental outcome psychological adjustment and quality of life in adolescents with congenitalheart disease. Developmental Medicine & Child Neurology, 55(12), 1143–1149. https://doi.org/10.1111/dmcn.12242CrossRef Schaefer, C., von Rhein, M., Knirsch, W., Huber, R., Natalucci, G., Caflisch, J., Landolt, M. A., & Latal, B. (2013). Neurodevelopmental outcome psychological adjustment and quality of life in adolescents with congenitalheart disease. Developmental Medicine & Child Neurology, 55(12), 1143–1149. https://​doi.​org/​10.​1111/​dmcn.​12242CrossRef
Metadaten
Titel
Neurodevelopmental Trajectory in a Child with Congenital Heart Disease
verfasst von
Hannah Greenbaum
Jacqueline H. Sanz
Mary T. Donofrio
Patrick Callahan
Publikationsdatum
01.03.2023
Verlag
Springer International Publishing
Erschienen in
Journal of Pediatric Neuropsychology / Ausgabe 1/2023
Print ISSN: 2199-2681
Elektronische ISSN: 2199-2673
DOI
https://doi.org/10.1007/s40817-022-00121-5

Weitere Artikel der Ausgabe 1/2023

Journal of Pediatric Neuropsychology 1/2023 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Nicht Creutzfeldt Jakob, sondern Abführtee-Vergiftung

29.05.2024 Hyponatriämie Nachrichten

Eine ältere Frau trinkt regelmäßig Sennesblättertee gegen ihre Verstopfung. Der scheint plötzlich gut zu wirken. Auf Durchfall und Erbrechen folgt allerdings eine Hyponatriämie. Nach deren Korrektur kommt es plötzlich zu progredienten Kognitions- und Verhaltensstörungen.

Schutz der Synapsen bei Alzheimer

29.05.2024 Morbus Alzheimer Nachrichten

Mit einem Neurotrophin-Rezeptor-Modulator lässt sich möglicherweise eine bestehende Alzheimerdemenz etwas abschwächen: Erste Phase-2-Daten deuten auf einen verbesserten Synapsenschutz.

Sozialer Aufstieg verringert Demenzgefahr

24.05.2024 Demenz Nachrichten

Ein hohes soziales Niveau ist mit die beste Versicherung gegen eine Demenz. Noch geringer ist das Demenzrisiko für Menschen, die sozial aufsteigen: Sie gewinnen fast zwei demenzfreie Lebensjahre. Umgekehrt steigt die Demenzgefahr beim sozialen Abstieg.

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.