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14.12.2021 | Case Reports

NUT Carcinoma of the Submandibular Gland: A Case at This Uncommon Site with Review of the Literature

verfasst von: Vanessa Moreno, Christopher A. French, Tianhua Guo, Hui Zhu, Songling Zhang, Darryl Duncan, Ron J. Karni, Angel I. Blanco, Syed H. Jafri, Karan Saluja

Erschienen in: Head and Neck Pathology | Ausgabe 3/2022

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Abstract

Nuclear protein in testis (NUT) carcinoma is a rare, highly aggressive, undifferentiated carcinoma that harbors a characteristic rearrangement of the NUTM1 gene. The majority arise in adolescents and young adults especially from the midline structures of the thorax, head, and neck. Until the present, there have only been three reported cases of NUT carcinoma of the submandibular gland, two of which were reported in children and another one in an adult from Korea. Here, we report the first case of NUT carcinoma arising in the submandibular gland of an adult female in the United States, representing the fourth case worldwide. A fine needle aspiration and biopsy was performed, and the diagnosis was confirmed by NUT immunohistochemical staining and fusion of the BRD4 (19p13.12) and NUTM1 (15q14) gene loci by fluorescence in-situ hybridization on the resection specimen. Salivary gland is an unusual site for NUT carcinoma and is rarely described in submandibular gland. We reviewed the clinicopathologic features of this entity at this site along with role of NUTM1 gene rearrangements in NUT tumorigenesis.

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Titel: NUT Carcinoma of the Submandibular Gland: A Case at This Uncommon Site with Review of the Literature
verfasst von: Vanessa Moreno
Christopher A. French
Tianhua Guo
Hui Zhu
Songling Zhang
Darryl Duncan
Ron J. Karni
Angel I. Blanco
Syed H. Jafri
Karan Saluja
Publikationsdatum: 14.12.2021
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 3/2022
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-021-01400-x

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

NUT Carcinoma of the Submandibular Gland: A Case at This Uncommon Site with Review of the Literature

Abstract

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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