Introduction
Methods
Results
Characteristic | DCB, N = 544 | DES, N = 693 | p value |
---|---|---|---|
Age, median (IQR) | 69 (61–75) | 69 (61–75) | 0.611 |
Male, n (%) | 429 (79) | 541 (78) | 0.742 |
Current/ex-smoker, n (%) | 336 (62) | 455 (66) | 0.112 |
Hypercholesterolaemia, n (%) | 186 (34) | 224 (32) | 0.492 |
Hypertension, n (%) | 307 (56) | 397 (57) | 0.762 |
Peripheral vascular disease, n (%) | 24 (4.4) | 33 (4.8) | 0.772 |
Cerebrovascular disease, n (%) | 42 (7.7) | 37 (5.3) | 0.0892 |
Myocardial infarction, n (%) | 93 (17) | 123 (18) | 0.762 |
Percutaneous coronary intervention, n (%) | 79 (15) | 86 (12) | 0.282 |
Coronary artery bypass graft, n (%) | 47 (8.6) | 56 (8.1) | 0.722 |
Atrial fibrillation, n (%) | 56 (10) | 52 (7.5) | 0.0842 |
Heart failure, n (%) | 18 (3.3) | 20 (2.9) | 0.672 |
Chronic obstructive pulmonary disease, n (%) | 18 (3.3) | 44 (6.3) | 0.0152 |
Diabetes, n (%) | 125 (23) | 153 (22) | 0.712 |
Family history, n (%) | 148 (27) | 174 (25) | 0.402 |
eGFR (ml/min/1.73 m2) median (IQR) | 79 (66–91) | 78 (67–91) | 0.851 |
Frailty, n (%) | > 0.993 | ||
Low | 541 (99) | 688 (99) | |
Intermediate | 3 (0.6) | 5 (0.7) | |
High | 0 (0) | 0 (0) |
Characteristic | DCB, N = 544 | DES, N = 693 | p value |
---|---|---|---|
Vessels treated, n (%) | 0.0062 | ||
LMS | 15 (2.8) | 27 (3.9) | |
LAD | 309 (57) | 376 (54) | |
LCx | 104 (19) | 98 (14) | |
RCA | 111 (20) | 172 (25) | |
Graft | 5 (0.9) | 20 (2.9) | |
Multivessel PCI, n (%) | 51 (9.4) | 83 (12) | 0.142 |
Patients with true bifurcation disease, n (%) | 63 (12) | 56 (8.1) | 0.0382 |
Patients with vessel treated ≥ 3 mm | 398 (73) | 594 (86) | < 0.0012 |
Dual antiplatelet therapy | 518 (95.2%) | 681 (98.3%) | < 0.0022 |
Duration of dual antiplatelet therapy, Median (IQR) days | 30 (29, 31) | 365 (364, 365) | < 0.0011 |
Lesions | |||
De novo lesions treated | DCB (640) | DES (831) | |
True bifurcation, n (%) | 64 (10) | 55 (6.6) | 0.022 |
Vessel diameter (mm), Median (IQR) | 3.00 (2.75–3.50) | 3.50 (3.00–3.75) | < 0.0011 |
Lesion length (mm), median (IQR) | 20 (20–30) | 24 (18–38) | 0.0431 |
Dissection grade post-DCB [14] | |||
A | 20 (3.1%) | n/a | |
B | 278 (43.4%) | n/a | |
C | 5 (0.8%) | n/a | |
D | 3 (0.5%) | n/a |
Mortality (Univariate) | N | Forest Plot | HR (95% CI) | p value |
---|---|---|---|---|
DCB/DES [DES] | 1237 | 1.28 (0.84 to 1.95) | 0.24 | |
Age | 1237 | 1.10 (1.07 to 1.12) | < 0.001 | |
Gender [female] | 1237 | 1.56 (1.00 to 2.45) | 0.050 | |
Smoking status [current/ex-smoker] | 1230 | 1.26 (0.81 to 1.95) | 0.31 | |
Hypercholesterolaemia | 1237 | 0.44 (0.26 to 0.74) | 0.002 | |
Hypertension | 1237 | 1.42 (0.93 to 2.17) | 0.11 | |
Peripheral vascular disease | 1237 | 1.51 (0.66 to 3.45) | 0.33 | |
Cerebrovascular event | 1237 | 1.22 (0.56 to 2.63) | 0.62 | |
Myocardial infarction | 1237 | 1.32 (0.81 to 2.15) | 0.26 | |
PCI | 1237 | 1.29 (0.75 to 2.21) | 0.35 | |
CABG | 1237 | 2.02 (1.15 to 3.57) | 0.015 | |
Atrial fibrillation | 1237 | 2.29 (1.31 to 3.98) | 0.003 | |
Heart failure | 1237 | 3.98 (1.92 to 8.24) | < 0.001 | |
COPD | 1237 | 2.01 (0.97 to 4.14) | 0.060 | |
Diabetes mellitus | 1237 | 1.58 (1.02 to 2.45) | 0.040 | |
Family history of CAD | 1237 | 0.60 (0.36 to 1.01) | 0.055 | |
eGFR | 1237 | 0.98 (0.97 to 0.99) | < 0.001 | |
Frailty score | 1237 | 1.50 (1.36 to 1.65) | < 0.001 | |
PCI to multiple vessels | 1237 | 0.84 (0.42 to 1.66) | 0.61 | |
Bifurcation disease | 1237 | 1.27 (0.68 to 2.39) | 0.45 | |
Average Vessel Diameter | 1231 | 0.91 (0.64 to 1.27) | 0.57 | |
Vessel Diameter ≥ 3 mm | 1237 | 1.10 (0.65 to 1.83) | 0.73 |
All-cause mortality (multivariate) | N | HR (95% CI) | p value |
---|---|---|---|
Age | 1237 | 1.07 (1.05 to 1.10) | < 0.001 |
Hypercholesterolaemia | 1237 | 0.59 (0.35 to 1.02) | 0.057 |
Coronary artery bypass graft | 1237 | 1.46 (0.82 to 2.58) | 0.20 |
Atrial fibrillation | 1237 | 1.24 (0.69 to 2.24) | 0.47 |
Heart failure | 1237 | 1.71 (0.77 to 3.80) | 0.19 |
Diabetes mellitus | 1237 | 1.35 (0.86 to 2.12) | 0.19 |
eGFR | 1237 | 1.00 (0.98 to 1.01) | 0.38 |
Frailty score | 1237 | 1.34 (1.21 to 1.49) | < 0.001 |