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Current Treatment Options in Gastroenterology

26.04.2024

Pancreatic Cyst Fluid Assessment: Updates in Genetic Analysis and Risk for Progression

verfasst von: Muaz Aijazi, MD, Rohit Das, MD

Erschienen in: Current Treatment Options in Gastroenterology

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Abstract

Purpose of Review

Given some pancreatic cysts require surveillance due to established malignant potential, efforts are being made to develop precise methods of early detection of advanced pancreatic neoplasia. This review focuses on genetic analysis of pancreatic cyst fluid for early detection of pancreatic cysts at high risk for neoplastic progression.

Recent Findings

Expanded, targeted next generation sequencing pathways, such as PancreaSeq, are highly sensitive and specific not just for cyst type, but also prognosticating progression to advanced neoplasia. Currently published guidelines aiding in management of pancreatic cyst surveillance have been shown to have inferior diagnostic performance when compared to algorithms involving next-generation sequencing.

Summary

Recent developments in novel next-generation sequencing pathways involving DNA/RNA based assays have increasingly allowed practitioners highly sensitive and specific modalities for early detection of advanced pancreatic neoplasia.

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Titel: Pancreatic Cyst Fluid Assessment: Updates in Genetic Analysis and Risk for Progression
verfasst von: Muaz Aijazi, MD
Rohit Das, MD
Publikationsdatum: 26.04.2024
Verlag: Springer US
Erschienen in: Current Treatment Options in Gastroenterology
Print ISSN: 1092-8472
Elektronische ISSN: 1534-309X
DOI: https://doi.org/10.1007/s11938-024-00446-4

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