Highlights
Introduction
Materials and methods
Ethical statement
Subjects and baseline characteristics
FNHTR and ATR definition
Data classification
Blood collection and real-time RT-PCR analysis
Statistical analysis
Results
Demographic characteristics
Variable | Number of patients/transfusion | Number of ATRs | P |
---|---|---|---|
Sex | n = 20,230 | n = 117 | 0.514 |
-Female | 9161 | 49 (0.53%) | |
-Male | 11,069 | 68 (0.62%) | |
Age | n = 20,230 | n = 117 | < 0.0001 |
- < 3 years | 9332 | 18 (0.19%) | |
-3-6 years | 8350 | 55 (0.66%) | |
-6 − 12 years | 1364 | 29 (2.13%) | |
−12-18 years | 1184 | 15 (1.27%) | |
Allergic history | n = 20,230 | n = 117 | 0.134 |
-None | 18,395 | 102 (0.55%) | |
-Drug | 651 | 7 (1.08%) | |
-Food, Rhinitis, pollen and others | 1184 | 8 (0.68%) | |
Number of transfusion per patient | n = 20,230 | n = 117 | < 0.0001 |
-1 | 7816 | 21 (0.27%) | |
−2-5 | 9751 | 56 (0.57%) | |
−6-10 | 2195 | 61 (2.78%) | |
- > 11 | 468 | 13 (2.78%) | |
Products | n = 28,840 | n = 236 | < 0.0001 |
-PC | 4292 | 142 (3.31%) | |
-SLRBC | 11,571 | 26 (0.22%) | |
-FFP | 12,801 | 64 (0.45%) | |
-Cryoprecipitate | 176 | 4 (2.27%) | |
Department | n = 28,840 | n = 236 | < 0.0001 |
-Hematology-Oncology | 6814 | 109 (1.59%) | |
-Surgical ICU | 2162 | 19 (0.88%) | |
-Pediatric ICU | 1876 | 5 (0.27%) | |
-Cardiothoracic surgery | 3139 | 18 (0.57%) | |
-General surgery | 2697 | 21 (0.78%) | |
-Outpatient | 9321 | 47 (0.50%) | |
-Other | 2831 | 17 (0.60%) | |
ATR type | n = 236 | ||
-urticaria | / | 162 (68.64%) | |
-FNHTR | / | 14 (5.93%) | |
-rash | / | 16 (6.78%) | |
-erythema | / | 16 (6.78%) | |
-skin itching | / | 8 (3.39%) | |
-Others | / | 20 (8.47%) |
The different expression level of IL1R2 in patients with and without ATR
Identification of risk factors for ATR
Variable | β | Univariate OR (95% CI) | P | β | Multivariate OR (95% CI) | P |
---|---|---|---|---|---|---|
Sex | −0.342 | 0.710 (0.421,1.198) | 0.200 | |||
PC | 3.004 | 20.175 (10.635, 38.275) | < 0.0001 | 3.476 | 32.318 (3.555, 293.782) | 0.002 |
Number of transfusion | 0.499 | 1.648 (1.426, 1.904) | < 0.0001 | 0.152 | 1.164 (0.646, 2.099) | 0.613 |
Age | 0.073 | 1.076 (1.016, 1.139) | 0.013 | 0.085 | 1.089 (0.877, 1.352) | 0.440 |
IL1R2 expression | 8.255 | 5.574 × 103 (2.569 × 102, 5.756 × 104) | < 0.0001 | 7.187 | 1.322 × 103 (1.171 × 102, 1.494 × 104) | < 0.0001 |