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Clinical Research in Cardiology
Erschienen in: Clinical Research in Cardiology 4/2024

24.04.2023 | Original Paper

Prognosis of cardiogenic shock with and without acute myocardial infarction: results from a prospective, monocentric registry

verfasst von: Tobias Schupp, Jonas Rusnak, Sascha Egner-Walter, Marinela Ruka, Jonas Dudda, Thomas Bertsch, Julian Müller, Kambis Mashayekhi, Péter Tajti, Mohammed Ayoub, Ibrahim Akin, Michael Behnes

Erschienen in: Clinical Research in Cardiology | Ausgabe 4/2024

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Abstract

Objective

The study investigates the prognostic impact of cardiogenic shock (CS) stratified by the presence or absence of acute myocardial infarction (AMI).

Background

Intensive care unit (ICU) related mortality in CS patients remains unacceptably high despite improvement concerning the treatment of CS patients.

Methods

Consecutive patients with CS from 2019 to 2021 were included monocentrically. The prognostic impact of CS related to AMI was compared to patients without AMI-related CS. The primary endpoint was 30-day all-cause mortality. Statistical analyses included Kaplan–Meier analyses, multivariable Cox proportional regression analyses and propensity score matching.

Results

273 CS patients were included (AMI-related CS: 49%; non-AMI-related CS: 51%). The risk of 30-day all-cause mortality was increased in patients with AMI-related CS (64% vs. 47%; HR = 1.653; 95% CI 1.199–2.281; p = 0.002), which was still observed after multivariable adjustment (HR = 1.696; 95% CI 1.153–2.494; p = 0.007). Even after propensity score matching (i.e., 87 matched pairs), AMI was still an independent predictor of 30-day mortality (HR = 1.524; 95% CI 1.020–2.276; p = 0.040). In contrast, non-ST-segment AMI (NSTEMI) and STEMI were associated with comparable prognosis (log-rank p = 0.528).

Conclusion

AMI-related CS was associated with increased 30-day all-cause mortality compared to patients with CS not related to AMI. In contrast, the prognosis of STEMI- and NSTEMI-CS patients was comparable.

Graphical abstract

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Metadaten
Titel
Prognosis of cardiogenic shock with and without acute myocardial infarction: results from a prospective, monocentric registry
verfasst von
Tobias Schupp
Jonas Rusnak
Sascha Egner-Walter
Marinela Ruka
Jonas Dudda
Thomas Bertsch
Julian Müller
Kambis Mashayekhi
Péter Tajti
Mohammed Ayoub
Ibrahim Akin
Michael Behnes
Publikationsdatum
24.04.2023
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Research in Cardiology / Ausgabe 4/2024
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI
https://doi.org/10.1007/s00392-023-02196-2

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