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02.04.2024 | REVIEW

Prostate Cancer Diagnosis and Treatment for Patients with Neurogenic Bladder: Does the Literature Support a Different Approach?

verfasst von: M. P. Bigarella, K. A. Richards

Erschienen in: Current Bladder Dysfunction Reports

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Abstract

Purpose of Review

In this review, the current literature available to patients and providers on the diagnosis and management of prostate cancer in patients with neurogenic bladder will be discussed. Topics include prostate cancer screening and diagnosis, radical prostatectomy and radiotherapy for prostate cancer, as well as surveillance.

Recent Findings

Neurogenic lower urinary tract dysfunction (NLUTD) patients are living longer due to better care, and cancer is becoming more frequent. This is partly due to the aging of this population, as well as intrinsic factors related to the underlying condition or urinary diversion, which poses them a greater risk of developing genitourinary malignancies. Although multiple studies have investigated this patient population, most are derived from large cohorts of spinal cord injury patients.

Summary

Many studies reported how PSA changes for different NGB patients. Few studies have investigated the management of prostate cancer, and good quality evidence for tailoring the care of this population is lacking. Although more evidence is available, improvement is still needed in using biomarkers for early diagnosis, specific screening protocols for different underlying conditions and urinary diversion, and standardized treatment recommendations based on long-term follow-up and surveillance.
Literatur
1.
Zurück zum Zitat Hartkopp A, et al. Survival and cause of death after traumatic spinal cord injury. A long-term epidemiological survey from Denmark. Spinal Cord. 1997;35(2):76–85.CrossRefPubMed Hartkopp A, et al. Survival and cause of death after traumatic spinal cord injury. A long-term epidemiological survey from Denmark. Spinal Cord. 1997;35(2):76–85.CrossRefPubMed
2.
Zurück zum Zitat Brandes SB, et al. Renal cell carcinoma in patients with prior spinal cord injury. J Spinal Cord Med. 2001;24(4):251–6.CrossRefPubMed Brandes SB, et al. Renal cell carcinoma in patients with prior spinal cord injury. J Spinal Cord Med. 2001;24(4):251–6.CrossRefPubMed
3.
Zurück zum Zitat Ismail S, et al. Prevalence, management, and prognosis of bladder cancer in patients with neurogenic bladder: a systematic review. Neurourol Urodyn. 2018;37(4):1386–95.CrossRefPubMed Ismail S, et al. Prevalence, management, and prognosis of bladder cancer in patients with neurogenic bladder: a systematic review. Neurourol Urodyn. 2018;37(4):1386–95.CrossRefPubMed
4.
Zurück zum Zitat Nahm LS, et al. Bladder cancer mortality after spinal cord injury over 4 decades. J Urol. 2015;193(6):1923–8.CrossRefPubMed Nahm LS, et al. Bladder cancer mortality after spinal cord injury over 4 decades. J Urol. 2015;193(6):1923–8.CrossRefPubMed
6.
Zurück zum Zitat Scott PA Sr, et al. Prostate cancer diagnosed in spinal cord-injured patients is more commonly advanced stage than in able-bodied patients. Urology. 2004;63(3):509–12.CrossRefPubMed Scott PA Sr, et al. Prostate cancer diagnosed in spinal cord-injured patients is more commonly advanced stage than in able-bodied patients. Urology. 2004;63(3):509–12.CrossRefPubMed
7.
Zurück zum Zitat Strauss DJ, et al. Trends in life expectancy after spinal cord injury. Arch Phys Med Rehabil. 2006;87(8):1079–85.CrossRefPubMed Strauss DJ, et al. Trends in life expectancy after spinal cord injury. Arch Phys Med Rehabil. 2006;87(8):1079–85.CrossRefPubMed
8.
Zurück zum Zitat Dennis LK, Lynch CF, Torner JC. Epidemiologic association between prostatitis and prostate cancer. Urology. 2002;60(1):78–83.CrossRefPubMed Dennis LK, Lynch CF, Torner JC. Epidemiologic association between prostatitis and prostate cancer. Urology. 2002;60(1):78–83.CrossRefPubMed
9.
Zurück zum Zitat Frisbie JH, Binard J. Low prevalence of prostatic cancer among myelopathy patients. J Am Paraplegia Soc. 1994;17(3):148–9.CrossRefPubMed Frisbie JH, Binard J. Low prevalence of prostatic cancer among myelopathy patients. J Am Paraplegia Soc. 1994;17(3):148–9.CrossRefPubMed
10.••
Zurück zum Zitat Barbonetti A, et al. Risk of prostate cancer in men with spinal cord injury: a systematic review and meta-analysis. Asian J Androl. 2018;20(6):555–60. Recent Meta-analysis of prostate cancer risk in SCI. Highlights rates of cancer detection, and characteristics of disease staging for this subset of patients. It showed a reduction in prostate cancer risk in SCI than controls.CrossRefPubMedPubMedCentral Barbonetti A, et al. Risk of prostate cancer in men with spinal cord injury: a systematic review and meta-analysis. Asian J Androl. 2018;20(6):555–60. Recent Meta-analysis of prostate cancer risk in SCI. Highlights rates of cancer detection, and characteristics of disease staging for this subset of patients. It showed a reduction in prostate cancer risk in SCI than controls.CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Bauman WA, et al. Metabolic and endocrine changes in persons aging with spinal cord injury. Assist Technol. 1999;11(2):88–96.CrossRefPubMed Bauman WA, et al. Metabolic and endocrine changes in persons aging with spinal cord injury. Assist Technol. 1999;11(2):88–96.CrossRefPubMed
12.
Zurück zum Zitat Huang TS, et al. Impaired hypothalamus-pituitary-adrenal axis in men with spinal cord injuries. Am J Phys Med Rehabil. 1998;77(2):108–12.CrossRefPubMed Huang TS, et al. Impaired hypothalamus-pituitary-adrenal axis in men with spinal cord injuries. Am J Phys Med Rehabil. 1998;77(2):108–12.CrossRefPubMed
13.
Zurück zum Zitat Safarinejad MR. Level of injury and hormone profiles in spinal cord-injured men. Urology. 2001;58(5):671–6.CrossRefPubMed Safarinejad MR. Level of injury and hormone profiles in spinal cord-injured men. Urology. 2001;58(5):671–6.CrossRefPubMed
14.
Zurück zum Zitat Bartoletti R, et al. Prostate growth and prevalence of prostate diseases in early onset spinal cord injuries. Eur Urol. 2009;56(1):142–8.CrossRefPubMed Bartoletti R, et al. Prostate growth and prevalence of prostate diseases in early onset spinal cord injuries. Eur Urol. 2009;56(1):142–8.CrossRefPubMed
15.
Zurück zum Zitat Hvarness H, Jakobsen H, Biering-Sorensen F. Men with spinal cord injury have a smaller prostate than men without. Scand J Urol Nephrol. 2007;41(2):120–3.CrossRefPubMed Hvarness H, Jakobsen H, Biering-Sorensen F. Men with spinal cord injury have a smaller prostate than men without. Scand J Urol Nephrol. 2007;41(2):120–3.CrossRefPubMed
16.
Zurück zum Zitat Lee WY, et al. Risk of prostate and bladder cancers in patients with spinal cord injury: a population-based cohort study. Urol Oncol. 2014;32(1):51-e1-7.CrossRef Lee WY, et al. Risk of prostate and bladder cancers in patients with spinal cord injury: a population-based cohort study. Urol Oncol. 2014;32(1):51-e1-7.CrossRef
17.
Zurück zum Zitat Pannek J, et al. Prostate volume in male patients with spinal cord injury: a question of nerves? BJU Int. 2013;112(4):495–500.CrossRefPubMed Pannek J, et al. Prostate volume in male patients with spinal cord injury: a question of nerves? BJU Int. 2013;112(4):495–500.CrossRefPubMed
18.
Zurück zum Zitat Zermann DH, et al. Central nervous system neurons labeled following the injection of pseudorabies virus into the rat prostate gland. Prostate. 2000;44(3):240–7.CrossRefPubMed Zermann DH, et al. Central nervous system neurons labeled following the injection of pseudorabies virus into the rat prostate gland. Prostate. 2000;44(3):240–7.CrossRefPubMed
19.
Zurück zum Zitat Shin YS, et al. Prostate volume and prostate-specific antigen in men with Parkinson’s disease are not different compared to age-matched control group: a prospective, case-controlled multicenter study. Prostate Int. 2015;3(2):62–4.CrossRefPubMedPubMedCentral Shin YS, et al. Prostate volume and prostate-specific antigen in men with Parkinson’s disease are not different compared to age-matched control group: a prospective, case-controlled multicenter study. Prostate Int. 2015;3(2):62–4.CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Bowman RM, et al. Spina bifida outcome: a 25-year prospective. Pediatr Neurosurg. 2001;34(3):114–20.CrossRefPubMed Bowman RM, et al. Spina bifida outcome: a 25-year prospective. Pediatr Neurosurg. 2001;34(3):114–20.CrossRefPubMed
22.•
Zurück zum Zitat Johnston AW, et al. Patterns of inpatient care for prostate cancer in men with spina bifida. Disabil Health J. 2020;13(2):100866. Clinical database analysis of prostate cancer in spina bifida patients, showing the trends of care in the care of SB population (from 1998 to 2014, extracted from National Inpatient Sample from the Healthcare Cost and Utilization Project. Johnston AW, et al. Patterns of inpatient care for prostate cancer in men with spina bifida. Disabil Health J. 2020;13(2):100866. Clinical database analysis of prostate cancer in spina bifida patients, showing the trends of care in the care of SB population (from 1998 to 2014, extracted from National Inpatient Sample from the Healthcare Cost and Utilization Project. 
23.
Zurück zum Zitat Wiener JS, Frimberger DC, Wood H. Spina Bifida health-care guidelines for men’s health. Urology. 2018;116:218–26.CrossRefPubMed Wiener JS, Frimberger DC, Wood H. Spina Bifida health-care guidelines for men’s health. Urology. 2018;116:218–26.CrossRefPubMed
24.
Zurück zum Zitat Eastham JA, et al. Clinically localized prostate cancer: AUA/ASTRO guideline, part II: principles of Active surveillance, principles of surgery, and follow-up. J Urol. 2022;208(1):19–25.CrossRefPubMed Eastham JA, et al. Clinically localized prostate cancer: AUA/ASTRO guideline, part II: principles of Active surveillance, principles of surgery, and follow-up. J Urol. 2022;208(1):19–25.CrossRefPubMed
25.
Zurück zum Zitat Eastham JA, et al. Clinically localized prostate cancer: AUA/ASTRO guideline, part I: introduction, risk assessment, staging, and risk-based management. J Urol. 2022;208(1):10–8.CrossRefPubMed Eastham JA, et al. Clinically localized prostate cancer: AUA/ASTRO guideline, part I: introduction, risk assessment, staging, and risk-based management. J Urol. 2022;208(1):10–8.CrossRefPubMed
26.
Zurück zum Zitat Eastham JA, et al. Clinically localized prostate cancer: AUA/ASTRO guideline. Part III: Principles of radiation and future directions. J Urol. 2022;208(1):26–33.CrossRefPubMed Eastham JA, et al. Clinically localized prostate cancer: AUA/ASTRO guideline. Part III: Principles of radiation and future directions. J Urol. 2022;208(1):26–33.CrossRefPubMed
27.
Zurück zum Zitat Eastham JA, Boorjian SA, Kirkby E. Clinically localized prostate cancer: AUA/ASTRO guideline. J Urol. 2022;208(3):505–7.CrossRefPubMed Eastham JA, Boorjian SA, Kirkby E. Clinically localized prostate cancer: AUA/ASTRO guideline. J Urol. 2022;208(3):505–7.CrossRefPubMed
28.
Zurück zum Zitat Lowrance W, et al. Updates to advanced prostate cancer: AUA/SUO guideline (2023). J Urol. 2023;209(6):1082–90.CrossRefPubMed Lowrance W, et al. Updates to advanced prostate cancer: AUA/SUO guideline (2023). J Urol. 2023;209(6):1082–90.CrossRefPubMed
29.••
Zurück zum Zitat Schaeffer EM, et al. Prostate cancer, version 42023, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2023;21(10):1067–96. Most recent prostate cancer guidelines for prostate cancer care according to The National Comprehensive Cancer Network. CrossRefPubMed Schaeffer EM, et al. Prostate cancer, version 42023, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2023;21(10):1067–96. Most recent prostate cancer guidelines for prostate cancer care according to The National Comprehensive Cancer Network. CrossRefPubMed
30.
Zurück zum Zitat Wei JT, et al. Early detection of prostate cancer: AUA/SUO guideline part I: prostate cancer screening. J Urol. 2023;210(1):46–53.CrossRefPubMed Wei JT, et al. Early detection of prostate cancer: AUA/SUO guideline part I: prostate cancer screening. J Urol. 2023;210(1):46–53.CrossRefPubMed
31.
Zurück zum Zitat Wei JT, et al. Early detection of prostate cancer: AUA/SUO guideline part II: considerations for a prostate biopsy. J Urol. 2023;210(1):54–63.CrossRefPubMed Wei JT, et al. Early detection of prostate cancer: AUA/SUO guideline part II: considerations for a prostate biopsy. J Urol. 2023;210(1):54–63.CrossRefPubMed
32.
Zurück zum Zitat Crawford ED, et al. Comorbidity and mortality results from a randomized prostate cancer screening trial. J Clin Oncol. 2011;29(4):355–61.CrossRefPubMed Crawford ED, et al. Comorbidity and mortality results from a randomized prostate cancer screening trial. J Clin Oncol. 2011;29(4):355–61.CrossRefPubMed
33.
Zurück zum Zitat Chen RC, et al. Association between choice of radical prostatectomy, external beam radiotherapy, brachytherapy, or active surveillance and patient-reported quality of life among men with localized prostate cancer. JAMA. 2017;317(11):1141–50.CrossRefPubMedPubMedCentral Chen RC, et al. Association between choice of radical prostatectomy, external beam radiotherapy, brachytherapy, or active surveillance and patient-reported quality of life among men with localized prostate cancer. JAMA. 2017;317(11):1141–50.CrossRefPubMedPubMedCentral
34.
Zurück zum Zitat Gammon SR, et al. Surgical treatment for prostate cancer in patients with prior spinal cord injury. Ann Surg Oncol. 2005;12(8):674–8.CrossRefPubMed Gammon SR, et al. Surgical treatment for prostate cancer in patients with prior spinal cord injury. Ann Surg Oncol. 2005;12(8):674–8.CrossRefPubMed
35.
Zurück zum Zitat Leach GE, et al. Post-prostatectomy incontinence: urodynamic findings and treatment outcomes. J Urol. 1996;155(4):1256–9.CrossRefPubMed Leach GE, et al. Post-prostatectomy incontinence: urodynamic findings and treatment outcomes. J Urol. 1996;155(4):1256–9.CrossRefPubMed
36.
Zurück zum Zitat Smith CP, Chancellor MB. Emerging role of botulinum toxin in the management of voiding dysfunction. J Urol. 2004;171(6 Pt 1):2128–37.CrossRefPubMed Smith CP, Chancellor MB. Emerging role of botulinum toxin in the management of voiding dysfunction. J Urol. 2004;171(6 Pt 1):2128–37.CrossRefPubMed
37.
Zurück zum Zitat Widmark A, Fransson P, Tavelin B. Self-assessment questionnaire for evaluating urinary and intestinal late side effects after pelvic radiotherapy in patients with prostate cancer compared with an age-matched control population. Cancer. 1994;74(9):2520–32.CrossRefPubMed Widmark A, Fransson P, Tavelin B. Self-assessment questionnaire for evaluating urinary and intestinal late side effects after pelvic radiotherapy in patients with prostate cancer compared with an age-matched control population. Cancer. 1994;74(9):2520–32.CrossRefPubMed
38.
Zurück zum Zitat Quek ML, et al. Combined radical prostatectomy and bladder augmentation for concomitant prostate cancer and detrusor instability. Urology. 2005;65(5):964–7.CrossRefPubMed Quek ML, et al. Combined radical prostatectomy and bladder augmentation for concomitant prostate cancer and detrusor instability. Urology. 2005;65(5):964–7.CrossRefPubMed
39.
Zurück zum Zitat Harper ME, Pierrepoint CG, Griffiths K. Carcinoma of the prostate: relationship of pretreatment hormone levels to survival. Eur J Cancer Clin Oncol. 1984;20(4):477–82.CrossRefPubMed Harper ME, Pierrepoint CG, Griffiths K. Carcinoma of the prostate: relationship of pretreatment hormone levels to survival. Eur J Cancer Clin Oncol. 1984;20(4):477–82.CrossRefPubMed
40.
Zurück zum Zitat Ribeiro M, Ruff P, Falkson G. Low serum testosterone and a younger age predict for a poor outcome in metastatic prostate cancer. Am J Clin Oncol. 1997;20(6):605–8.CrossRefPubMed Ribeiro M, Ruff P, Falkson G. Low serum testosterone and a younger age predict for a poor outcome in metastatic prostate cancer. Am J Clin Oncol. 1997;20(6):605–8.CrossRefPubMed
41.••
Zurück zum Zitat National Spinal Cord Injury Statistical Center. Spinal cord injury facts and figures at a glance. J Spinal Cord Med. 2013:36(1):1-2. https://doi.org/10.1179/1079026813Z.000000000136. Most updated statistics for SCI patients in the US, with median age of presentation, overall survival. This data sheet is a quick reference on demographic and condition status for 36,275 person with tSCI collected through 2022 by 31 federally funded SCI Model Systems National Spinal Cord Injury Statistical Center. Spinal cord injury facts and figures at a glance. J Spinal Cord Med. 2013:36(1):1-2. https://​doi.​org/​10.​1179/​1079026813Z.​000000000136. Most updated statistics for SCI patients in the US, with median age of presentation, overall survival. This data sheet is a quick reference on demographic and condition status for 36,275 person with tSCI collected through 2022 by 31 federally funded SCI Model Systems
Metadaten
Titel
Prostate Cancer Diagnosis and Treatment for Patients with Neurogenic Bladder: Does the Literature Support a Different Approach?
verfasst von
M. P. Bigarella
K. A. Richards
Publikationsdatum
02.04.2024
Verlag
Springer US
Erschienen in
Current Bladder Dysfunction Reports
Print ISSN: 1931-7212
Elektronische ISSN: 1931-7220
DOI
https://doi.org/10.1007/s11884-024-00746-6

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