nach oben

European Archives of Psychiatry and Clinical Neuroscience

Erschienen in:

08.10.2022 | Original Paper

Psychological trauma as a transdiagnostic risk factor for mental disorder: an umbrella meta-analysis

verfasst von: Bridget Hogg, Itxaso Gardoki-Souto, Alicia Valiente-Gómez, Adriane Ribeiro Rosa, Lydia Fortea, Joaquim Radua, Benedikt L. Amann, Ana Moreno-Alcázar

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 2/2023

Einloggen, um Zugang zu erhalten

Abstract

This umbrella review is the first to systematically examine psychological trauma as a transdiagnostic risk factor across psychiatric conditions. We searched Pubmed, Scopus, and PsycNET databases from inception until 01/05/2021 for systematic reviews/meta-analyses evaluating the association between psychological trauma and at least one diagnosed mental disorder. We re-calculated the odds ratio (OR), then classified the association as convincing, highly suggestive, suggestive, or weak, based on the number of cases and controls with and without psychological trauma, random-effects p value, the 95% confidence interval of the largest study, heterogeneity between studies, 95% prediction interval, small-study effect, and excess significance bias. Additional outcomes were the association between specific trauma types and specific mental disorders, and a sensitivity analysis for childhood trauma. Transdiagnosticity was assessed using TRANSD criteria. The review was pre-registered in Prospero CRD42020157308 and followed PRISMA/MOOSE guidelines. Fourteen reviews met inclusion criteria, comprising 16,277 cases and 77,586 controls. Psychological trauma met TRANSD criteria as a transdiagnostic factor across different diagnostic criteria and spectra. There was highly suggestive evidence of an association between psychological trauma at any time-point and any mental disorder (OR = 2.92) and between childhood trauma and any mental disorder (OR = 2.90). Regarding specific trauma types, convincing evidence linked physical abuse (OR = 2.36) and highly suggestive evidence linked sexual abuse (OR = 3.47) with a range of mental disorders, and convincing evidence linked emotional abuse to anxiety disorders (OR = 3.05); there were no data for emotional abuse with other disorders. These findings highlight the importance of preventing early traumatic events and providing trauma-informed care in early intervention and psychiatric services.

Nur mit Berechtigung zugänglich

Tyrer P (2015) Mental Illness, Etiology of. International Encyclopedia of the Social & Behavioral Sciences, 2nd edn. Elsevier Inc, Amsterdam, pp 204–208CrossRef

Huang L, Flatow R, Tenly B, et al (2014) SAMHSA’s concept of trauma and guidance for a trauma-informed approach. HHS Publication No. (SMA) 14–4884. Subst Abus Ment Heal Serv Adm US Dep Heal Hum Serv 1–27

Varese F, Smeets F, Drukker M et al (2012) Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective-and cross-sectional cohort studies. Schizophr Bull 38:661–671. https://doi.org/10.1093/schbul/sbs050CrossRefPubMedPubMedCentral

Frazier PA (2012) Trauma psychology. In Altmaier EM, Hansen J-IC (eds) The Oxford handbook of counselling psychology. Oxford University Press, p 807–836

Friedman MJ, Resick PA, Bryant RA et al (2011) Classification of trauma and stressor-related disorders in DSM-5. Depress Anxiety 28:737–749. https://doi.org/10.1002/da.20845CrossRefPubMed

Green JG, McLaughlin KA, Berglund PA et al (2010) Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders. Arch Gen Psychiatry 67:113–123. https://doi.org/10.1001/archgenpsychiatry.2009.186CrossRefPubMedPubMedCentral

Hughes K, Bellis MA, Hardcastle KA et al (2017) The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis. Lancet Public Heal 2:e356–e366. https://doi.org/10.1016/S2468-2667(17)30118-4CrossRef

McGrath JJ, Saha S, Lim CCW et al (2017) Trauma and psychotic experiences: transnational data from the world mental health survey. Br J Psychiatry 211:373–380. https://doi.org/10.1192/bjp.bp.117.205955CrossRefPubMedPubMedCentral

McLaughlin KA, Green JG, Gruber MJ et al (2012) Childhood adversities and first onset of psychiatric disorders in a national sample of US adolescents. Arch Gen Psychiatry 69:1151–1160. https://doi.org/10.1001/archgenpsychiatry.2011.2277CrossRefPubMedPubMedCentral

10.

Copeland WE, Shanahan L, Hinesley J et al (2018) Association of childhood trauma exposure with adult psychiatric disorders and functional outcomes. JAMA Netw Open. https://doi.org/10.1001/jamanetworkopen.2018.4493CrossRefPubMedPubMedCentral

11.

Mauritz MW, Goossens PJJ, Draijer N, van Achterberg T (2013) Prevalence of interpersonal trauma exposure and trauma-related disorders in severe mental illness. Eur J Psychotraumatol. https://doi.org/10.3402/ejpt.v4i0.19985CrossRefPubMedPubMedCentral

12.

Cuijpers P, Smit F, Unger F et al (2011) The disease burden of childhood adversities in adults: a population-based study. Child Abus Negl 35:937–945. https://doi.org/10.1016/j.chiabu.2011.06.005CrossRef

13.

Bellis MA, Hughes K, Ford K et al (2019) Life course health consequences and associated annual costs of adverse childhood experiences across Europe and North America: a systematic review and meta-analysis. Lancet Public Heal 4:e517–e528. https://doi.org/10.1016/S2468-2667(19)30145-8CrossRef

14.

Benjet C, Bromet E, Karam EG et al (2016) The epidemiology of traumatic event exposure worldwide: results from the world mental health survey consortium. Psychol Med 46:327–343. https://doi.org/10.1017/S0033291715001981CrossRefPubMed

15.

Kilpatrick DG, Resnick HS, Milanak ME et al (2013) National estimates of exposure to traumatic events and PTSD prevalence using DSM-IV and DSM-5 criteria. J Trauma Stress 26:537–547. https://doi.org/10.1002/jts.21848CrossRefPubMedPubMedCentral

16.

Kessler RC, McLaughlin KA, Green JG et al (2010) Childhood adversities and adult psychopathology in the WHO world mental health surveys. Br J Psychiatry 197:378–385. https://doi.org/10.1192/bjp.bp.110.080499CrossRefPubMedPubMedCentral

17.

Maj M (2005) “Psychiatric comorbidity”: an artefact of current diagnostic systems? Br J Psychiatry 186:182–184. https://doi.org/10.1192/bjp.186.3.182CrossRefPubMed

18.

Dalgleish T, Black M, Johnston D, Bevan A (2020) Transdiagnostic approaches to mental health problems: current status and future directions. J Consult Clin Psychol 88:179. https://doi.org/10.1037/CCP0000482CrossRefPubMedPubMedCentral

19.

Nolen-Hoeksema S, Watkins ER (2011) A heuristic for developing transdiagnostic models of psychopathology: explaining multifinality and divergent trajectories. Perspect Psychol Sci 6:589–609. https://doi.org/10.1177/1745691611419672CrossRefPubMed

20.

McLaughlin KA, Colich NL, Rodman AM, Weissman DG (2020) Mechanisms linking childhood trauma exposure and psychopathology: a transdiagnostic model of risk and resilience. BMC Med 18:1–11. https://doi.org/10.1186/s12916-020-01561-6CrossRef

21.

Fusar-Poli P, Solmi M, Brondino N et al (2019) Transdiagnostic psychiatry: a systematic review. World Psychiatry 18:192–207. https://doi.org/10.1002/wps.20631CrossRefPubMedPubMedCentral

22.

Fusar-Poli P (2019) TRANSD recommendations: improving transdiagnostic research in psychiatry. World Psychiatry 18:361–362. https://doi.org/10.1002/wps.20681CrossRefPubMedPubMedCentral

23.

American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, Arlington, VACrossRef

24.

World Health Organization (2022) International Classification of Diseases, Eleventh Revision (ICD-11). https://icd.who.int/browse11. Accessed 27 Jul 2022

25.

Fusar-Poli P, Radua J (2018) Ten simple rules for conducting umbrella reviews. Evid Based Ment Health 21:95–100. https://doi.org/10.1136/ebmental-2018-300014CrossRefPubMed

26.

Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339:332–336. https://doi.org/10.1136/bmj.b2535CrossRef

27.

Stroup DF, Berlin JA, Morton SC et al (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. J Am Med Assoc 283:2008–2012. https://doi.org/10.1001/jama.283.15.2008CrossRef

28.

Shea BJ, Grimshaw JM, Wells GA et al (2007) Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol 7:10. https://doi.org/10.1186/1471-2288-7-10CrossRefPubMedPubMedCentral

29.

Higgins JPT, Green S (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration

30.

Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. Br Med J 315:629–634. https://doi.org/10.1136/bmj.315.7109.629CrossRef

31.

Radua J, Ramella-Cravaro V, Ioannidis JPA et al (2018) What causes psychosis? An umbrella review of risk and protective factors. World Psychiatry 17:49–66. https://doi.org/10.1002/wps.20490CrossRefPubMedPubMedCentral

32.

Ioannidis JPA (2009) Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analyses. CMAJ 181:488–493. https://doi.org/10.1503/cmaj.081086CrossRefPubMedPubMedCentral

33.

Petereit-Haack G, Bolm-Audorff U, Romero Starke K, Seidler A (2020) Occupational risk for post-traumatic stress disorder and trauma-related depression: a systematic review with meta-analysis. Int J Environ Res Public Health. https://doi.org/10.3390/ijerph17249369CrossRefPubMedPubMedCentral

34.

Wang C-W, Chan CLW, Ho RTH (2013) Prevalence and trajectory of psychopathology among child and adolescent survivors of disasters: a systematic review of epidemiological studies across 1987–2011. Soc Psychiatry Psychiatr Epidemiol 48:1697–1720. https://doi.org/10.1007/s00127-013-0731-xCrossRefPubMed

35.

van Denderen M, de Keijser J, Kleen M, Boelen PA (2015) Psychopathology among homicidally bereaved individuals: a systematic review. Trauma Violence Abuse 16:70–80. https://doi.org/10.1177/1524838013515757CrossRefPubMed

36.

Spencer AE, Faraone SV, Bogucki OE et al (2016) Examining the association between posttraumatic stress disorder and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis. J Clin Psychiatry 77:72–83. https://doi.org/10.4088/JCP.14r09479CrossRefPubMed

37.

Bendall S, Jackson HJ, Hulbert CA, McGorry PD (2008) Childhood trauma and psychotic disorders: a systematic, critical review of the evidence. Schizophr Bull 34:568–579. https://doi.org/10.1093/schbul/sbm121CrossRefPubMed

38.

Martins CMS, de Tofoli SM, von BaesJuruena CWM (2011) Analysis of the occurrence of early life stress in adult psychiatric patients: a systematic review. Psychol Neurosci 4:219–227. https://doi.org/10.3922/j.psns.2011.2.007CrossRef

39.

Palmier-Claus JE, Berry K, Bucci S et al (2016) Relationship between childhood adversity and bipolar affective disorder: systematic review and meta-analysis. Br J Psychiatry 209:454–459. https://doi.org/10.1192/bjp.bp.115.179655CrossRefPubMed

40.

Brander G, Pérez-Vigil A, Larsson H, Mataix-Cols D (2016) Systematic review of environmental risk factors for obsessive-compulsive disorder: a proposed roadmap from association to causation. Neurosci Biobehav Rev 65:36–62. https://doi.org/10.1016/j.neubiorev.2016.03.011CrossRefPubMed

41.

Cabizuca M, Marques-Portella C, Mendlowicz MV et al (2009) Posttraumatic stress disorder in parents of children with chronic illnesses: a meta-analysis. Heal Psychol 28:379–388. https://doi.org/10.1037/a0014512CrossRef

42.

Cunningham T, Hoy K, Shannon C (2016) Does childhood bullying lead to the development of psychotic symptoms? A meta-analysis and review of prospective studies. Psychosis 8:48–59. https://doi.org/10.1080/17522439.2015.1053969CrossRef

43.

de Aquino Ferreira LF, Queiroz Pereira FH, Neri Benevides AML, Aguiar Melo MC (2018) Borderline personality disorder and sexual abuse: a systematic review. Psychiatry Res 262:70–77. https://doi.org/10.1016/j.psychres.2018.01.043CrossRefPubMed

44.

Fernandes V, Osorio FL (2015) Are there associations between early emotional trauma and anxiety disorders? Evidence from a systematic literature review and meta-analysis. Eur Psychiatry 30:756–764. https://doi.org/10.1016/j.eurpsy.2015.06.004CrossRefPubMed

45.

Swartzman S, Booth JN, Munro A, Sani F (2017) Posttraumatic stress disorder after cancer diagnosis in adults: a meta-analysis. Depress Anxiety 34:327–339. https://doi.org/10.1002/da.22542CrossRefPubMed

46.

Teicher MH, Samson JA, Anderson CM, Ohashi K (2016) The effects of childhood maltreatment on brain structure, function and connectivity. Nat Rev Neurosci 1710(17):652–666. https://doi.org/10.1038/nrn.2016.111CrossRef

47.

Cross D, Fani N, Powers A, Bradley B (2017) Neurobiological development in the context of childhood trauma. Clin Psychol Sci Pract 24:111–124. https://doi.org/10.1111/cpsp.12198CrossRef

48.

Miller AH, Haroon E, Raison CL, Felger JC (2013) Cytokine targets in the brain: impact on neurotransmitters and neurocircuits. Depress Anxiety 30:297–306. https://doi.org/10.1002/da.22084CrossRefPubMedPubMedCentral

49.

Houtepen LC, Vinkers CH, Carrillo-Roa T et al (2016) Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nat Commun 7:10967. https://doi.org/10.1038/ncomms10967CrossRefPubMedPubMedCentral

50.

Fries GR, Vasconcelos-Moreno MP, Gubert C et al (2015) Hypothalamic-pituitary-adrenal axis dysfunction and illness progression in bipolar disorder. Int J Neuropsychopharmacol 18:pyu043. https://doi.org/10.1093/ijnp/pyu043CrossRef

51.

Wright CE, Strike PC, Brydon L, Steptoe A (2005) Acute inflammation and negative mood: Mediation by cytokine activation. Brain Behav Immun 19:345–350. https://doi.org/10.1016/j.bbi.2004.10.003CrossRefPubMed

52.

Dziurkowska E, Wesolowski M (2021) Cortisol as a biomarker of mental disorder severity. J Clin Med 10:5204. https://doi.org/10.3390/jcm10215204CrossRefPubMedPubMedCentral

53.

Faravelli C, Lo SC, Godini L et al (2012) Childhood stressful events, HPA axis and anxiety disorders. World J Psychiatry 2:13. https://doi.org/10.5498/WJP.V2.I1.13CrossRefPubMedPubMedCentral

54.

Thomas N, Gurvich C, Kulkarni J (2019) Borderline personality disorder, trauma, and the hypothalamus-pituitary-adrenal axis. Neuropsychiatr Dis Treat 15:2601–2612. https://doi.org/10.2147/NDT.S198804CrossRefPubMedPubMedCentral

55.

Masten CL, Guyer AE, Hodgdon HB et al (2008) Recognition of facial emotions among maltreated children with high rates of post-traumatic stress disorder. Child Abus Negl 32:139–153. https://doi.org/10.1016/j.chiabu.2007.09.006CrossRef

56.

Stanton KJ, Denietolis B, Goodwin BJ, Dvir Y (2020) Childhood trauma and psychosis: an updated review. Child Adolesc Psychiatr Clin N Am 29:115–129. https://doi.org/10.1016/j.chc.2019.08.004CrossRefPubMed

57.

Misiak B, Stramecki F, Gawęda Ł et al (2018) Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder: a systematic review. Mol Neurobiol 55:5075–5100. https://doi.org/10.1007/s12035-017-0708-yCrossRefPubMed

58.

Cattane N, Rossi R, Lanfredi M, Cattaneo A (2017) Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms. BMC Psychiatry 17:221. https://doi.org/10.1186/s12888-017-1383-2CrossRefPubMedPubMedCentral

59.

Lopizzo N, Chiavetto LB, Cattane N et al (2015) Gene-environment interaction in major depression: focus on experience-dependent biological systems. Front Psychiatry. https://doi.org/10.3389/fpsyt.2015.00068CrossRefPubMedPubMedCentral

60.

Witt SH, Streit F, Jungkunz M et al (2017) Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. Transl Psychiatry 7:e1155. https://doi.org/10.1038/tp.2017.115CrossRefPubMedPubMedCentral

61.

Ji D, Francesconi M, Flouri E, Papachristou E (2022) The role of inflammatory markers and cortisol in the association between early social cognition abilities and later internalising or externalising problems: evidence from a U.K. birth cohort. Brain Behav Immun. https://doi.org/10.1016/J.BBI.2022.07.002CrossRefPubMed

62.

Révész D, Verhoeven JE, Milaneschi Y et al (2014) Dysregulated physiological stress systems and accelerated cellular aging. Neurobiol Aging 35:1422–1430. https://doi.org/10.1016/j.neurobiolaging.2013.12.027CrossRefPubMed

63.

Tomiyama AJ, O’Donovan A, Lin J et al (2012) Does cellular aging relate to patterns of allostasis?. An examination of basal and stress reactive HPA axis activity and telomere length. Physiol Behav 106:40–45. https://doi.org/10.1016/j.physbeh.2011.11.016CrossRefPubMed

64.

Porter C, Palmier-Claus J, Branitsky A et al (2020) Childhood adversity and borderline personality disorder: a meta-analysis. Acta Psychiatr Scand 141:6–20. https://doi.org/10.1111/ACPS.13118CrossRefPubMed

65.

Bozzatello P, Rocca P, Baldassarri L et al (2021) The role of trauma in early onset borderline personality disorder: a biopsychosocial perspective. Front Psychiatry 12:1512CrossRef

66.

Cattane N, Rossi R, Lanfredi M, Cattaneo A (2017) Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms. BMC Psychiatry 17:1–14. https://doi.org/10.1186/s12888-017-1383-2CrossRef

67.

Stoltenborgh M, Bakermans-Kranenburg MJ, Van Ijzendoorn MH (2013) The neglect of child neglect: a meta-analytic review of the prevalence of neglect. Soc Psychiatry Psychiatr Epidemiol 48:345–355. https://doi.org/10.1007/s00127-012-0549-yCrossRefPubMed

68.

Kessler RC, Ruscio AM, Shear K, Wittchen HU (2010) Epidemiology of anxiety disorders. Curr Top Behav Neurosci 2:21–35CrossRefPubMed

69.

Choi J, Jeong B, Rohan ML et al (2009) Preliminary evidence for white matter tract abnormalities in young adults exposed to parental verbal abuse. Biol Psychiatry 65:227–234. https://doi.org/10.1016/j.biopsych.2008.06.022CrossRefPubMed

70.

Heim CM, Mayberg HS, Mletzko T et al (2013) Decreased cortical representation of genital somatosensory field after childhood sexual abuse. Am J Psychiatry 170:616–623. https://doi.org/10.1176/appi.ajp.2013.12070950CrossRefPubMed

71.

Kleber RJ (2019) Trauma and public mental health: a focused review. Front Psychiatry. https://doi.org/10.3389/FPSYT.2019.00451CrossRefPubMedPubMedCentral

72.

Sweeney A, Filson B, Kennedy A et al (2018) A paradigm shift: relationships in trauma-informed mental health services. BJPsych Adv 24:319–333. https://doi.org/10.1192/bja.2018.29CrossRefPubMedPubMedCentral

73.

Fredrickson R (2019) Trauma-informed care for infant and early childhood abuse. J Aggress Maltreatment Trauma 28:389–406. https://doi.org/10.1080/10926771.2019.1601143CrossRef

74.

Purgato M, Gross AL, Betancourt T et al (2018) Focused psychosocial interventions for children in low-resource humanitarian settings: a systematic review and individual participant data meta-analysis. Lancet Glob Heal 6:e390–e400. https://doi.org/10.1016/S2214-109X(18)30046-9CrossRef

75.

Marie-Mitchell A, Kostolansky R (2019) A systematic review of trials to improve child outcomes associated with adverse childhood experiences. Am J Prev Med 56:756–764. https://doi.org/10.1016/j.amepre.2018.11.030CrossRefPubMed

76.

Barlow DH, Harris BA, Eustis EH, Farchione TJ (2020) The unified protocol for transdiagnostic treatment of emotional disorders. World Psychiatry 19:245–246. https://doi.org/10.1002/wps.20748CrossRefPubMedPubMedCentral

77.

Keen N, Hunter ECM, Peters E (2017) Integrated trauma-focused cognitive-behavioural therapy for post-traumatic stress and psychotic symptoms: a case-series study using imaginal reprocessing strategies. Front Psychiatry 8:1. https://doi.org/10.3389/fpsyt.2017.00092CrossRef

78.

Valiente-Gómez A, Moreno-Alcázar A, Treen D et al (2017) EMDR beyond PTSD: a systematic literature review. Front Psychol 8:1668. https://doi.org/10.3389/fpsyg.2017.01668CrossRefPubMedPubMedCentral

79.

Novo P, Landin-Romero R, Radua J et al (2014) Eye movement desensitization and reprocessing therapy in subsyndromal bipolar patients with a history of traumatic events: a randomized, controlled pilot-study. Psychiatry Res 219:122–128. https://doi.org/10.1016/j.psychres.2014.05.012CrossRefPubMed

80.

Faretta E, Farra MD (2019) Efficacy of EMDR therapy for anxiety disorders. J EMDR Pract Res 13:325–332. https://doi.org/10.1891/1933-3196.13.4.325CrossRef

81.

Marsden Z, Lovell K, Blore D et al (2018) A randomized controlled trial comparing EMDR and CBT for obsessive–compulsive disorder. Clin Psychol Psychother 25:e10–e18. https://doi.org/10.1002/cpp.2120CrossRefPubMed

82.

Carletto S, Malandrone F, Berchialla P et al (2021) Eye movement desensitization and reprocessing for depression: a systematic review and meta-analysis. Eur J Psychotraumatol. https://doi.org/10.1080/20008198.2021.1894736CrossRefPubMedPubMedCentral

83.

Peters E, Hardy A, Dudley R et al (2022) Multisite randomised controlled trial of trauma-focused cognitive behaviour therapy for psychosis to reduce post-traumatic stress symptoms in people with co-morbid post-traumatic stress disorder and psychosis, compared to treatment as usual: study protoco. Trials. https://doi.org/10.1186/s13063-022-06215-xCrossRefPubMedPubMedCentral

84.

Valiente-Gómez A, Pujol N, Moreno-Alcázar A et al (2020) A Multicenter phase II RCT to compare the effectiveness of EMDR versus TAU in patients with a first-episode psychosis and psychological trauma: a protocol design. Front Psychiatry 10:1023. https://doi.org/10.3389/fpsyt.2019.01023CrossRefPubMedPubMedCentral

85.

Moreno-Alcázar A, Radua J, Landín-Romero R et al (2017) Eye movement desensitization and reprocessing therapy versus supportive therapy in affective relapse prevention in bipolar patients with a history of trauma: study protocol for a randomized controlled trial. Trials 18:160. https://doi.org/10.1186/s13063-017-1910-yCrossRefPubMedPubMedCentral

86.

Frissa S, Hatch SL, Fear NT et al (2016) Challenges in the retrospective assessment of trauma: comparing a checklist approach to a single item trauma experience screening question. BMC Psychiatry 16:20. https://doi.org/10.1186/s12888-016-0720-1CrossRefPubMedPubMedCentral

87.

Danese A, Widom CS (2020) Objective and subjective experiences of child maltreatment and their relationships with psychopathology. Nat Hum Behav 4:811–818. https://doi.org/10.1038/s41562-020-0880-3CrossRefPubMed

88.

Blanco L, Sió A, Hogg B et al (2020) Traumatic events in dual disorders: prevalence and clinical characteristics. J Clin Med 9:1–14. https://doi.org/10.3390/jcm9082553CrossRef

Titel: Psychological trauma as a transdiagnostic risk factor for mental disorder: an umbrella meta-analysis
verfasst von: Bridget Hogg
Itxaso Gardoki-Souto
Alicia Valiente-Gómez
Adriane Ribeiro Rosa
Lydia Fortea
Joaquim Radua
Benedikt L. Amann
Ana Moreno-Alcázar
Publikationsdatum: 08.10.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 2/2023
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-022-01495-5

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Psychological trauma as a transdiagnostic risk factor for mental disorder: an umbrella meta-analysis

Abstract

Neu im Fachgebiet Psychiatrie

Hörschwäche erhöht Demenzrisiko unabhängig von Beta-Amyloid

So wirken verschiedene Alkoholika auf den Blutdruck

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

ADHS-Medikation erhöht das kardiovaskuläre Risiko

Update Psychiatrie

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2023

One year after the COVID-19 outbreak in Germany: long-term changes in depression, anxiety, loneliness, distress and life satisfaction

Suicidality in psychiatric emergency department situations during the first and the second wave of COVID-19 pandemic

Changes in the pattern of suicides and suicide attempt admissions in relation to the COVID-19 pandemic

Maternal smoking around birth may lower the protective effects of breastfeeding on anxiety, depression and neuroticism in adult offspring: a UK biobank study

Analysis of malingered psychological symptoms in a clinical sample for early detection in initial interviews

Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea

Neu im Fachgebiet Psychiatrie

Hörschwäche erhöht Demenzrisiko unabhängig von Beta-Amyloid

So wirken verschiedene Alkoholika auf den Blutdruck

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

ADHS-Medikation erhöht das kardiovaskuläre Risiko

Update Psychiatrie