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07.03.2022 | Original Article

Radiomics analysis of [¹⁸F]-fluoro-2-deoxyglucose positron emission tomography for the prediction of cervical lymph node metastasis in tongue squamous cell carcinoma

verfasst von: Takaharu Kudoh, Akihiro Haga, Keiko Kudoh, Akira Takahashi, Motoharu Sasaki, Yasusei Kudo, Hitoshi Ikushima, Youji Miyamoto

Erschienen in: Oral Radiology | Ausgabe 1/2023

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Abstract

Objectives

This study aimed to create a predictive model for cervical lymph node metastasis (CLNM) in patients with tongue squamous cell carcinoma (SCC) based on radiomics features detected by [¹⁸F]-fluoro-2-deoxyglucose (¹⁸F-FDG) positron emission tomography (PET).

Methods

A total of 40 patients with tongue SCC who underwent ¹⁸F-FDG PET imaging during their first medical examination were enrolled. During the follow-up period (mean 28 months), 20 patients had CLNM, including six with late CLNM, whereas the remaining 20 patients did not have CLNM. Radiomics features were extracted from ¹⁸F-FDG PET images of all patients irrespective of metal artifact, and clinicopathological factors were obtained from the medical records. Late CLNM was defined as the CLNM that occurred after major treatment. The least absolute shrinkage and selection operator (LASSO) model was used for radiomics feature selection and sequential data fitting. The receiver operating characteristic curve analysis was used to assess the predictive performance of the ¹⁸F-FDG PET-based model and clinicopathological factors model (CFM) for CLNM.

Results

Six radiomics features were selected from LASSO analysis. The average values of the area under the curve (AUC), accuracy, sensitivity, and specificity of radiomics analysis for predicting CLNM from ¹⁸F-FDG PET images were 0.79, 0.68, 0.65, and 0.70, respectively. In contrast, those of the CFM were 0.54, 0.60, 0.60, and 0.60, respectively. The ¹⁸F-FDG PET-based model showed significantly higher AUC than that of the CFM.

Conclusions

The ¹⁸F-FDG PET-based model has better potential for diagnosing CLNM and predicting late CLNM in patients with tongue SCC than the CFM.

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Titel: Radiomics analysis of [18F]-fluoro-2-deoxyglucose positron emission tomography for the prediction of cervical lymph node metastasis in tongue squamous cell carcinoma
verfasst von: Takaharu Kudoh
Akihiro Haga
Keiko Kudoh
Akira Takahashi
Motoharu Sasaki
Yasusei Kudo
Hitoshi Ikushima
Youji Miyamoto
Publikationsdatum: 07.03.2022
Verlag: Springer Nature Singapore
Erschienen in: Oral Radiology / Ausgabe 1/2023
Print ISSN: 0911-6028
Elektronische ISSN: 1613-9674
DOI: https://doi.org/10.1007/s11282-022-00600-7

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Radiomics analysis of [¹⁸F]-fluoro-2-deoxyglucose positron emission tomography for the prediction of cervical lymph node metastasis in tongue squamous cell carcinoma