Erschienen in:
26.07.2023
Recent updates in autonomic research: orthostatic hypotension and cognitive function in Parkinson disease and multiple system atrophy, the skin as a window into synuclein pathology, and RFC1 repeat expansions in hereditary sensory autonomic neuropathies
verfasst von:
Pitcha Chompoopong, Sandra Reiter-Campeau
Erschienen in:
Clinical Autonomic Research
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Ausgabe 4/2023
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Excerpt
Orthostatic hypotension (OH) reflects insufficient hemodynamic adjustment to postural changes, which may exceed the threshold of cerebral autoregulation resulting in decreased cerebral perfusion during orthostatic stress. Cognitive testing during upright position in Parkinson disease (PD) patients with OH demonstrated transient impairment in cognition with more pronounced deficits in executive function, memory, and visuospatial domains [
1]. Patients who experience repeated bouts of OH may be predisposed to chronic brain hypoxia leading to progressive cognitive decline and dementia, especially in the setting of synergistic neurodegenerative processes. Multiple studies have shown the association between OH and dementia as well as cognitive impairment progression to dementia, even when OH was asymptomatic [
2,
3]. …