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Inflammation
Erschienen in: Inflammation 5/2023

24.06.2023 | REVIEW

Role of Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) in Immune and Inflammatory Diseases

verfasst von: Xixi Bian, Honglu Xue, Dehuai Jing, Yan Wang, Guangxi Zhou, Fengqin Zhu

Erschienen in: Inflammation | Ausgabe 5/2023

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Abstract

Serum/glucocorticoid-regulated kinase 1 (SGK1), a member of the serine/threonine protein kinase gene family, is primarily regulated by serum and glucocorticoids. SGK1 is involved in the development of tumors and fibrotic diseases. However, relatively little research has been conducted on their role in immune and inflammatory diseases. SGK1 may act as a pivotal immune regulatory gene by modulating immune cells (e.g., T cells, macrophages, dendritic cells, and neutrophils) and functions and is involved in the pathogenesis of some immune and inflammatory diseases, such as inflammatory bowel disease, multiple sclerosis, allergic diseases, sepsis, and major depressive disorder. This review aims to provide an overview of the latest research focusing on the immune and inflammatory regulatory roles of SGK1 and provide new insights into diagnostic and therapeutic approaches for immune and inflammatory diseases.
Literatur
1.
Webster, M.K., L. Goya, Y. Ge, et al. 1993. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Molecular and Cellular Biology 13 (4): 2031–2040.PubMedPubMedCentral
2.
Elahi, M., Y. Motoi, S. Shimonaka, et al. 2021. High-fat diet-induced activation of SGK1 promotes Alzheimer’s disease-associated tau pathology. Human Molecular Genetics 30 (18): 1693–1710.PubMedPubMedCentral
3.
Xu, H., J. Li, L. Jin, et al. 2022. Intrauterine hyperglycemia impairs endometrial receptivity via up-regulating SGK1 in diabetes. Science China Life Sciences 65 (8): 1578–1589.PubMed
4.
Yang, X., N. Niu, C. Liang, et al. 2020. Stimulation of epithelial sodium channels in endothelial cells by bone morphogenetic protein-4 contributes to salt-sensitive hypertension in rats. Oxidative Medicine and Cellular Longevity 2020: 3921897.PubMedPubMedCentral
5.
Zhou, X., B. Packialakshmi, Y. Xiao, et al. 2017. Progression of experimental autoimmune encephalomyelitis is associated with up-regulation of major sodium transporters in the mouse kidney cortex under a normal salt diet. Cellular Immunology 317: 18–25.PubMed
6.
Guo, H.X., N. Ye, P. Yan, et al. 2018. Sodium chloride exacerbates dextran sulfate sodium-induced colitis by tuning proinflammatory and antiinflammatory lamina propria mononuclear cells through p38/MAPK pathway in mice. World Journal of Gastroenterology 24 (16): 1779–1794.PubMedPubMedCentral
7.
Schmid, E., N.T. Xuan, N. Zahir, et al. 2014. Serum- and glucocorticoid-inducible kinase 1 sensitive NF-κB signaling in dendritic cells. Cellular Physiology and Biochemistry 34 (3): 943–954.PubMed
8.
Wu, C., N. Yosef, T. Thalhamer, et al. 2013. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 496 (7446): 513–517.PubMedPubMedCentral
9.
Kobayashi, T., M. Deak, N. Morrice, et al. 1999. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Journal of Biochemistry 344 Pt 1 (Pt 1): 189–97.
10.
Coric, T., N. Hernandez, D. Alvarez de la Rosa, et al. 2004. Expression of ENaC and serum- and glucocorticoid-induced kinase 1 in the rat intestinal epithelium. American Journal of Physiology-Gastrointestinal and Liver Physiology 286(4):G663–70.
11.
Lang, F., and P. Cohen. 2001. Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Science's Signal Transduction Knowledge Environment 2001 (108): re17.
12.
Lang, F., C. Böhmer, M. Palmada, et al. 2006. (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiological Reviews 86 (4): 1151–1178.PubMed
13.
Waldegger, S., M. Erdel, U.O. Nagl, et al. 1998. Genomic organization and chromosomal localization of the human SGK protein kinase gene. Genomics 51 (2): 299–302.PubMed
14.
Dattilo, V., R. Amato, N. Perrotti, et al. 2020. The emerging role of SGK1 (serum- and glucocorticoid-regulated kinase 1) in major depressive disorder: Hypothesis and mechanisms. Frontiers in Genetics 11: 826.PubMedPubMedCentral
15.
Zhou, R., and P.M. Snyder. 2005. Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation. Journal of Biological Chemistry 280 (6): 4518–4523.PubMed
16.
Bai, J.A., G.F. Xu, L.J. Yan, et al. 2015. SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis. World Journal of Gastroenterology 21 (20): 6180–6193.PubMedPubMedCentral
17.
Zhu, L., L.M. Dai, H. Shen, et al. 2019. Qing Chang Hua Shi granule ameliorate inflammation in experimental rats and cell model of ulcerative colitis through MEK/ERK signaling pathway. Biomedicine & Pharmacotherapy 116: 108967.
18.
Voelkl, J., T.T. Luong, R. Tuffaha, et al. 2018. SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling. The Journal of Clinical Investigation 128 (7): 3024–3040.PubMedPubMedCentral
19.
Wang, M., Y. Xue, L. Shen, et al. 2019. Inhibition of SGK1 confers vulnerability to redox dysregulation in cervical cancer. Redox Biology 24: 101225.PubMedPubMedCentral
20.
Chen, D., Y. Wang, F. Yang, et al. 2021. The circRAB3IP Mediated by eIF4A3 and LEF1 contributes to enzalutamide resistance in prostate cancer by targeting miR-133a-3p/miR-133b/SGK1 Pathway. Frontiers in Oncology 11: 752573.PubMedPubMedCentral
21.
Gokon, Y., F. Fujishima, Y. Taniyama, et al. 2020. Glucocorticoid receptor and serum- and glucocorticoid-induced kinase-1 in esophageal adenocarcinoma and adjacent Barrett’s esophagus. Pathology International 70 (6): 355–363.PubMed
22.
Abbruzzese, C., G. Catalogna, E. Gallo, et al. 2017. The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme. Oncotarget 8 (67): 110743–110755.PubMedPubMedCentral
23.
Abbruzzese, C., S. Matteoni, M. Persico, et al. 2019. The small molecule SI113 hinders epithelial-to-mesenchymal transition and subverts cytoskeletal organization in human cancer cells. Journal of Cellular Physiology 234 (12): 22529–22542.PubMed
24.
Conza, D., P. Mirra, G. Calì, et al. 2017. The SGK1 inhibitor SI113 induces autophagy, apoptosis, and endoplasmic reticulum stress in endometrial cancer cells. Journal of Cellular Physiology 232 (12): 3735–3743.PubMed
25.
D’Antona, L., R. Amato, C. Talarico, et al. 2015. SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation. Cellular Physiology and Biochemistry 35 (5): 2006–2018.PubMed
26.
D’Antona, L., V. Dattilo, G. Catalogna, et al. 2019. In preclinical model of ovarian cancer, the SGK1 inhibitor SI113 counteracts the development of paclitaxel resistance and restores drug sensitivity. Translational Oncology 12 (8): 1045–1055.PubMedPubMedCentral
27.
Catalogna, G., C. Talarico, V. Dattilo, et al. 2017. The SGK1 kinase inhibitor SI113 sensitizes theranostic effects of the 64CuCl2 in human glioblastoma multiforme cells. Cellular Physiology and Biochemistry 43 (1): 108–119.PubMed
28.
Talarico, C., V. Dattilo, L. D’Antona, et al. 2016. SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells. Oncotarget 7 (13): 15868–15884.PubMedPubMedCentral
29.
Talarico, C., L. D’Antona, D. Scumaci, et al. 2015. Preclinical model in HCC: The SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy. Oncotarget 6 (35): 37511–37525.PubMedPubMedCentral
30.
Cronkite, D.A., and T.M. Strutt. 2018. The regulation of inflammation by innate and adaptive lymphocytes. Journal of Immunology Research 2018: 1467538.PubMedPubMedCentral
31.
van der Meer, J.W., and M.G. Netea. 2013. A salty taste to autoimmunity. New England Journal of Medicine 368 (26): 2520–2521.PubMed
32.
Wu, C., Z. Chen, S. Xiao, et al. 2018. SGK1 Governs the reciprocal development of Th17 and regulatory T cells. Cell Reports 22 (3): 653–665.PubMed
33.
Malik, S., S. Sadhu, S. Elesela, et al. 2017. Transcription factor Foxo1 is essential for IL-9 induction in T helper cells. Nature Communications 8 (1): 815.PubMedPubMedCentral
34.
Kleinewietfeld, M., A. Manzel, J. Titze, et al. 2013. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 496 (7446): 518–522.PubMedPubMedCentral
35.
Matthias, J., S. Heink, F. Picard, et al. 2020. Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments. The Journal of Clinical Investigation 130 (9): 4587–4600.PubMedPubMedCentral
36.
Venkatesha, S.H., and K.D. Moudgil. 2019. Celastrol suppresses experimental autoimmune encephalomyelitis via MAPK/SGK1-regulated mediators of autoimmune pathology. Inflammation Research 68 (4): 285–296.PubMedPubMedCentral
37.
Wang, L., L. Li, M.Y. Quan, et al. 2018. Nordihydroguaiaretic acid can suppress progression of experimental autoimmune encephalomyelitis. IUBMB Life 70 (5): 432–436.PubMed
38.
Heikamp, E.B., C.H. Patel, S. Collins, et al. 2014. The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex. Nature Immunology 15 (5): 457–464.PubMedPubMedCentral
39.
Leipe, J., F. Pirronello, H. Schulze-Koops, et al. 2020. Altered T cell plasticity favours Th17 cells in early arthritis. Rheumatology (Oxford) 59 (10): 2754–2763.PubMed
40.
Amato, R., V. Dattilo, C. Brescia, et al. 2022. Th17-gene expression profile in patients with chronic venous disease and venous ulcers: genetic modulations and preliminary clinical evidence. Biomolecules 12 (7).
41.
Yang, Y.H., R. Istomine, F. Alvarez, et al. 2020. Salt sensing by serum/glucocorticoid-regulated kinase 1 promotes Th17-like inflammatory adaptation of Foxp3(+) regulatory T cells. Cell Reports 30 (5): 1515-1529.e4.PubMed
42.
Sumida, T., M.R. Lincoln, C.M. Ukeje, et al. 2018. Activated β-catenin in Foxp3(+) regulatory T cells links inflammatory environments to autoimmunity. Nature Immunology 19 (12): 1391–1402.PubMedPubMedCentral
43.
Shapouri-Moghaddam, A., S. Mohammadian, H. Vazini, et al. 2018. Macrophage plasticity, polarization, and function in health and disease. Journal of Cellular Physiology 233 (9): 6425–6440.PubMed
44.
Xi, X., J. Zhang, J. Wang, et al. 2019. SGK1 mediates hypoxic pulmonary hypertension through promoting macrophage infiltration and activation. Analytical Cellular Pathology (Amsterdam) 2019: 3013765.PubMed
45.
Ren, J., X. Han, H. Lohner, et al. 2021. Serum- and glucocorticoid-inducible kinase 1 promotes alternative macrophage polarization and restrains inflammation through FoxO1 and STAT3 Signaling. The Journal of Immunology 207 (1): 268–280.PubMed
46.
Sangphech, N., and T. Palaga. 2021. Cross-regulation of notch/AKT and serum/glucocorticoid regulated kinase 1 (SGK1) in IL-4-stimulated human macrophages. International Immunopharmacology 101 (Pt A): 108312.PubMed
47.
Worbs, T., S.I. Hammerschmidt, and R. Förster. 2017. Dendritic cell migration in health and disease. Nature Reviews Immunology 17 (1): 30–48.PubMed
48.
Van Beusecum, J.P., N.R. Barbaro, Z. McDowell, et al. 2019. High salt activates CD11c(+) Antigen-presenting cells via SGK (serum glucocorticoid kinase) 1 to promote renal inflammation and salt-sensitive hypertension. Hypertension 74 (3): 555–563.PubMed
49.
Tubbs, A.L., B. Liu, T.D. Rogers, et al. 2017. Dietary Salt Exacerbates Experimental Colitis. The Journal of Immunology 199 (3): 1051–1059.PubMed
50.
Liew, P.X., and P. Kubes. 2019. The neutrophil’s role during health and disease. Physiological Reviews 99 (2): 1223–1248.PubMed
51.
Su, Y., S.M. Qadri, F.S. Cayabyab, et al. 2014. Regulation of methylglyoxal-elicited leukocyte recruitment by endothelial SGK1/GSK3 signaling. Biochimica et Biophysica Acta 1843 (11): 2481–2491.PubMed
52.
Burgon, J., A.L. Robertson, P. Sadiku, et al. 2014. Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution. The Journal of Immunology 192 (4): 1796–1805.PubMed
53.
Han, H., C. Liu, M. Li, et al. 2022. Increased intracellular Cl(-) concentration mediates neutrophil extracellular traps formation in atherosclerotic cardiovascular diseases. Acta Pharmacologica Sinica 43 (11): 2848–2861.PubMed
54.
Lang, P.A., D. Graf, K.M. Boini, et al. 2011. Cell volume, the serum and glucocorticoid inducible kinase 1 and the liver. Zeitschrift fur Gastroenterologie 49 (6): 713–719.PubMed
55.
Gan, W., J. Ren, T. Li, et al. 2018. The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation. Biochimica et Biophysica Acta, Molecular Basis of Disease 1864 (1): 1–10.PubMed
56.
Medina-Jover, F., N. Gendrau-Sanclemente, and F. Viñals. 2020. SGK1 is a signalling hub that controls protein synthesis and proliferation in endothelial cells. FEBS Letters 594 (19): 3200–3215.PubMed
57.
Zhang, M., H. Chen, M.S. Liu, et al. 2021. Serum- and glucocorticoid-inducible kinase 1 promotes insulin resistance in adipocytes via degradation of insulin receptor substrate 1. Diabetes/Metabolism Research and Reviews 37 (4): e3451.PubMed
58.
Lee, S.H., J.E. Kwon, and M.L. Cho. 2018. Immunological pathogenesis of inflammatory bowel disease. Intestinal Research 16 (1): 26–42.PubMedPubMedCentral
59.
Lightner, A.L., S. Vogler, J. McMichael, et al. 2021. Dysplastic progression to adenocarcinoma is equivalent in ulcerative colitis and Crohn’s disease. Journal of Crohn’s & Colitis 15 (1): 24–34.
60.
He, T., K. Wang, P. Zhao, et al. 2022. Integrative computational approach identifies immune-relevant biomarkers in ulcerative colitis. FEBS Open Bio 12 (2): 500–515.PubMedPubMedCentral
61.
Spagnuolo, R., V. Dattilo, L. D’Antona, et al. 2018. Deregulation of SGK1 in ulcerative colitis: A paradoxical relationship between immune cells and colonic epithelial cells. Inflammatory Bowel Diseases 24 (9): 1967–1977.PubMed
62.
Dames, P., T. Bergann, A. Fromm, et al. 2015. Interleukin-13 affects the epithelial sodium channel in the intestine by coordinated modulation of STAT6 and p38 MAPK activity. Journal of Physiology 593 (24): 5269–5282.PubMedPubMedCentral
63.
Caldito, N.G., S. Saidha, E.S. Sotirchos, et al. 2018. Brain and retinal atrophy in African-Americans versus Caucasian-Americans with multiple sclerosis: A longitudinal study. Brain 141 (11): 3115–3129.PubMedPubMedCentral
64.
Wang, L., B. Li, M.Y. Quan, et al. 2017. Mechanism of oxidative stress p38MAPK-SGK1 signaling axis in experimental autoimmune encephalomyelitis (EAE). Oncotarget 8 (26): 42808–42816.PubMedPubMedCentral
65.
Hucke, S., M. Eschborn, M. Liebmann, et al. 2016. Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity. Journal of Autoimmunity 67: 90–101.PubMed
66.
Li, B., T.B. Tan, L. Wang, et al. 2019. p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis. Aging (Albany NY). 11 (3): 898–907.PubMedPubMedCentral
67.
Hira, S., B. Packialakshmi, E. Tang, et al. 2021. Dexamethasone upregulates mitochondrial Tom20, Tom70, and MnSOD through SGK1 in the kidney cells. Journal of Physiology and Biochemistry 77 (1): 1–11.PubMed
68.
Hira, S., B. Packialakshmi, and X. Zhou. 2019. EAE-induced upregulation of mitochondrial MnSOD is associated with increases of mitochondrial SGK1 and Tom20 protein in the mouse kidney cortex. The Journal of Physiological Sciences 69 (5): 723–732.PubMed
69.
Inoue, K., E. Sakuma, H. Morimoto, et al. 2016. Serum- and glucocorticoid-inducible kinases in microglia. Biochemical and Biophysical Research Communications 478 (1): 53–59.PubMedPubMedCentral
70.
Inoue, K., H. Morimoto, and T. Ueki. 2020. Modulation of microglial activity by salt load and SGK1. NeuroReport 31 (7): 571–577.PubMed
71.
Asai, H., K. Inoue, E. Sakuma, et al. 2018. Potential implication of SGK1-dependent activity change in BV-2 microglial cells. International Journal of Physiology, Pathophysiology and Pharmacology 10 (2): 115–123.PubMedPubMedCentral
72.
Chen, B., C. Xie, T. Shi, et al. 2023. Activation of Swell1 in microglia suppresses neuroinflammation and reduces brain damage in ischemic stroke. Neurobiology of Diseases 176: 105936.
73.
Zayed, H. 2020. Novel comprehensive bioinformatics approaches to determine the molecular genetic susceptibility profile of moderate and severe asthma. International Journal of Molecular Sciences 21 (11).
74.
Tong, R., L. Xu, L. Liang, et al. 2018. Analysis of the levels of Th9 cells and cytokines in the peripheral blood of mice with bronchial asthma. Experimental and Therapeutic Medicine 15 (3): 2480–2484.PubMedPubMedCentral
75.
Wu, X., W. Jiang, X. Wang, et al. 2020. SGK1 enhances Th9 cell differentiation and airway inflammation through NF-κB signaling pathway in asthma. Cell and Tissue Research 382 (3): 563–574.PubMed
76.
Matthias, J., J. Maul, R. Noster, et al. 2019. Sodium chloride is an ionic checkpoint for human T(H)2 cells and shapes the atopic skin microenvironment. Science Translational Medicine 11 (480).
77.
Hammond, N.E., A. Kumar, P. Kaur, et al. 2022. Estimates of sepsis prevalence and outcomes in adult patients in the ICU in India: A cross-sectional study. Chest 161 (6): 1543–1554.PubMed
78.
Li, J., L. Liu, X. Zhou, et al. 2020. Melatonin attenuates sepsis-induced acute lung injury through improvement of epithelial sodium channel-mediated alveolar fluid clearance via activation of SIRT1/SGK1/Nedd4-2 signaling pathway. Frontiers in Pharmacology 11: 590652.PubMedPubMedCentral
79.
Tong, Y., Y. Yang, and Q. Feng. 2022. Characterization of lncRNA-based ceRNA network and potential prognostic hub genes for sepsis. Evid Based Complement Alternat Med. 2022: 1485033.PubMedPubMedCentral
80.
Frodl, T., A. Carballedo, E.M. Frey, et al. 2014. Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder. Development and Psychopathology 26 (4 Pt 2): 1209–1217.PubMed
81.
Meng, P., Q. Zhu, H. Yang, et al. 2019. Leonurine promotes neurite outgrowth and neurotrophic activity by modulating the GR/SGK1 signaling pathway in cultured PC12 cells. NeuroReport 30 (4): 247–254.PubMedPubMedCentral
82.
Jefsen, O.H., B. Elfving, G. Wegener, et al. 2021. Transcriptional regulation in the rat prefrontal cortex and hippocampus after a single administration of psilocybin. Journal of Psychopharmacology 35 (4): 483–493.PubMed
83.
Jin, J., S.N. Kim, X. Liu, et al. 2016. miR-17-92 Cluster regulates adult hippocampal neurogenesis, anxiety, and depression. Cell Reports 16 (6): 1653–1663.PubMed
84.
Dong, S.Q., S.S. Wang, J.X. Zhu, et al. 2019. Oleanolic acid decreases SGK1 in the hippocampus in corticosterone-induced mice. Steroids 149: 108419.PubMed
85.
Hernandez, A.L., A. Kitz, C. Wu, et al. 2015. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. The Journal of Clinical Investigation 125 (11): 4212–4222.PubMedPubMedCentral
86.
Aguiar, S.L.F., M.C.G. Miranda, M.A.F. Guimarães, et al. 2017. High-salt diet induces IL-17-dependent gut inflammation and exacerbates colitis in mice. Frontiers in Immunology 8: 1969.PubMed
87.
Knezović, A., N. Kolobarić, I. Drenjančević, et al. 2022. Role of oxidative stress in vascular low-grade inflammation initiation due to acute salt loading in young healthy individuals. Antioxidants (Basel) 11 (3).
88.
Alarcón, G.S. 2011. Multiethnic lupus cohorts: what have they taught us? Reumatología Clínica 7 (1): 3–6.
89.
Donadei, C., A. Angeletti, C. Cantarelli, et al. 2019. Erythropoietin inhibits SGK1-dependent TH17 induction and TH17-dependent kidney disease. JCI Insight 5 (10).
90.
Yang, X., G. Yao, W. Chen, et al. 2015. Exacerbation of lupus nephritis by high sodium chloride related to activation of SGK1 pathway. International Immunopharmacology 29 (2): 568–573.PubMed
91.
Singh, S., J.J. Vennila, V.P. Snijesh, et al. 2016. Implying Analytic Measures for Unravelling Rheumatoid Arthritis Significant Proteins Through Drug-Target Interaction. Interdisciplinary Sciences 8 (2): 122–131.
92.
Jiang, X., B. Sundström, L. Alfredsson, et al. 2016. High sodium chloride consumption enhances the effects of smoking but does not interact with SGK1 polymorphisms in the development of ACPA-positive status in patients with RA. Annals of the Rheumatic Diseases 75 (5): 943–946.PubMed
93.
Bruscoli, S., M. Febo, C. Riccardi, et al. 2021. Glucocorticoid therapy in inflammatory bowel disease: Mechanisms and clinical practice. Frontiers in Immunology 12: 691480.PubMedPubMedCentral
94.
Lai, Y., X.Y. Luo, H.J. Guo, et al. 2020. PO-322 exerts potent immunosuppressive effects in vitro and in vivo by selectively inhibiting SGK1 activity. British Journal of Pharmacology 177 (7): 1666–1676.PubMedPubMedCentral
Metadaten
Titel
Role of Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) in Immune and Inflammatory Diseases
verfasst von
Xixi Bian
Honglu Xue
Dehuai Jing
Yan Wang
Guangxi Zhou
Fengqin Zhu
Publikationsdatum
24.06.2023
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 5/2023
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-023-01857-8

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