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14.09.2023 | Review

Seizure outcomes after resection of primary brain tumors in pediatric patients: a systematic review and meta-analysis

verfasst von: Kalman A. Katlowitz, Prazwal Athukuri, Himanshu Sharma, Huy Dang, Astitva Soni, A. Basit Khan, Fatema Malbari, Nisha Gadgil, Howard L. Weiner

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2023

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Abstract

Purpose

Primary brain neoplasms are the most common solid tumors in pediatric patients and seizures are a common presenting symptom. Surgical intervention improves oncologic outcomes and seizure burden. A better understanding of factors that influence seizure outcomes in the surgical management of primary brain tumors of childhood can guide treatment approach thereby improving patient quality of life.

Methods

We performed a systematic analysis using articles queried from PubMed, EMBASE, and Cochrane published from January 1990 to August 2022 to determine predictors of seizure outcomes in pediatric patients undergoing resection of primary brain tumors.

Results

We identified 24 retrospective cohort studies, one prospective cohort study, and one mixed retrospective and prospective study for the systematic analysis. A total of 831 pediatric patients were available for analysis. 668 (80.4%) patients achieved seizure freedom after surgery. Complete tumor resection increased the likelihood of a seizure-free (Engel I) outcome compared to subtotal resection (OR 7.1, 95% CI 2.3–21.9). Rates of Engel I seizure outcomes did not significantly differ based on factors such as age at seizure onset, duration of epilepsy, gender, tumor laterality, or age at surgery, but trended towards significance for improved outcomes in temporal lobe tumors.

Conclusion

Primary brain tumors in the pediatric population are commonly associated with seizures. Resection of these lesions reduces seizure burden and is associated with high rates of seizure freedom. Complete resection, compared to subtotal resection, significantly increases the likelihood of seizure-free outcomes.

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Titel: Seizure outcomes after resection of primary brain tumors in pediatric patients: a systematic review and meta-analysis
verfasst von: Kalman A. Katlowitz
Prazwal Athukuri
Himanshu Sharma
Huy Dang
Astitva Soni
A. Basit Khan
Fatema Malbari
Nisha Gadgil
Howard L. Weiner
Publikationsdatum: 14.09.2023
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 3/2023
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-023-04446-9

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