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Oral Cancer

Erschienen in:

14.08.2018 | Original Article

Single nucleotide polymorphism rs17849071 G/T in the PIK3CA gene is inversely associated with oral cancer

verfasst von: Sejal Shah, Girish Mishra, Kiran Kalia

Erschienen in: Oral Cancer | Ausgabe 3-4/2018

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Abstract

Purpose

Oral squamous cell carcinoma (OSCC)—a subset of head and neck cancer is the sixth most common cancer worldwide and leading disease in India. The genes involved in PI3 K/AKT (Phosphatidylinositol 3-kinase—Akt) pathway, such as PIK3CA (Phosphoinositide-3-kinase catalytic α) and PTEN (Phosphatase and tensin homologue) were found to be associated with OSCC. The present study was aimed to find the genetic association of various polymorphisms in intron 9 of the PIK3CA gene and intron 5 of PTEN gene with primary OSCC tumors.

Methodology

50 OSCC patients for PIK3CA gene, 60 OSCC patients for PTEN gene and 72 healthy individuals were included in the study. PCR-direct sequencing analyzed the polymorphisms in intron 9 of PIK3CA and intron 5 of PTEN gene.

Results and conclusion

We observed rs114587137 (C>T) and rs17849071 (T>G) SNPs in intron 9 of the PIK3CA gene and rs35560700 (C>T) SNP in intron 5 of the PTEN gene. T allele of rs17849071 (T>G) was associated with the high-risk allele for developing OSCC; while G allele seemed to have the protective effect against OSCC (P = 0.02). We found an inverse association of rs17849071 (T>G) with OSCC development.

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Titel: Single nucleotide polymorphism rs17849071 G/T in the PIK3CA gene is inversely associated with oral cancer
verfasst von: Sejal Shah
Girish Mishra
Kiran Kalia
Publikationsdatum: 14.08.2018
Verlag: Springer International Publishing
Erschienen in: Oral Cancer / Ausgabe 3-4/2018
Elektronische ISSN: 2509-8837
DOI: https://doi.org/10.1007/s41548-018-0012-1

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Single nucleotide polymorphism rs17849071 G/T in the PIK3CA gene is inversely associated with oral cancer

Abstract

Purpose

Methodology

Results and conclusion

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Abstract

Purpose

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Results and conclusion

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Neu im Fachgebiet Zahnmedizin

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

Klinikreform soll zehntausende Menschenleben retten

Darf man die Behandlung eines Neonazis ablehnen?

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

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