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European Archives of Psychiatry and Clinical Neuroscience

03.05.2024 | Original Paper

Smoking may increase the usage of antidepressant: evidence from genomic perspective analysis

verfasst von: Yucai Qu, Zhiqiang Du, Yuan Shen, Qin Zhou, Zhenhe Zhou, Ying Jiang, Haohao Zhu

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience

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Abstract

This study uses the two-sample Mendelian randomization (TSMR) method to explore the causal relationships between smoking initiation (SMKI), never smoking (NSMK), past tobacco smoking (PTSMK), and the usage of antidepressants (ATD). Single-nucleotide polymorphisms (SNPs) with genome-wide significance (P < 5E−08) related to SMKI, NSMK, and PTSMK were selected from the genome-wide association study (GWAS) database as instrumental variables (IVs). The main method, inverse variance weighted (IVW), was utilized to investigate the causal relationship. The results demonstrated a positive causal relationship between SMKI and ATD use, where SMKI leads to an increase in ATD use. Conversely, NSMK and PTSMK showed a negative causal relationship with ATD use, meaning that NSMK and PTSMK lead to a reduction in ATD use. Additionally, sensitivity analysis showed that the results of this study were robust and reliable. Using the TSMR method and from a genetic perspective, this study found that SMKI leads to an increase in ATD use, while NSMK and PTSMK reduce ATD use.
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Metadaten
Titel
Smoking may increase the usage of antidepressant: evidence from genomic perspective analysis
verfasst von
Yucai Qu
Zhiqiang Du
Yuan Shen
Qin Zhou
Zhenhe Zhou
Ying Jiang
Haohao Zhu
Publikationsdatum
03.05.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-024-01802-2

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